Articles tagged with Stem Cell Research
Researchers uncover glycolysis' instructive potential in early embryonic development, controlling cell fate decisions and end-state appearance of stem cell-based embryo models. By manipulating glucose concentration, they demonstrate glycolysis' role as an upstream regulator of signalling pathways.
A team of experts at Cincinnati Children's reports achieving a milestone in growing human liver organoid tissue that faithfully reproduces key zones, nearly doubling rodent survival rate. This breakthrough paves the way for studying human liver biology and disease, accelerating drug development and potentially leading to repair tissues.
A phase 1 clinical trial found that nerve cells derived from embryonic stem cells can produce dopamine, a chemical lacking in Parkinson's patients. The treatment has been licensed to BlueRock Therapeutics and is expected to proceed to a larger patient group in the first half of 2025.
A UC Riverside-led study found that adult stem cells rely on histone chaperones to maintain their regenerative capacity. The researchers discovered that disrupting these proteins can lead to specific changes in stem cell identity, potentially guiding them into desired cell types.
A new method captures totipotency using a short-term high-dose treatment of Pladienolide B, reprogramming classical mouse embryonic stem cells into transient totipotent blastomere-like stem cells. These cells exhibit remarkable developmental potential and self-organize into blastoid structures mimicking early embryonic development.
A new study found that mesenchymal stem cell-derived extracellular vesicles significantly enhance survival and facilitate substantial peripheral blood recovery in mice exposed to high-dose irradiation. The treatment promoted hematopoietic recovery, with increases in red blood cell, platelet, white blood cell, and hemoglobin levels.
This study reveals NAT10 is crucial for spermatogonial proliferation and differentiation. In Nat10-deficient mice, infertility occurs with reduced testicular sizes, germ cell depletion, and a loss of spermatogonial homeostasis.
The ISSCR has elected new Vice President, Treasurer, Clerk, and Directors to lead the organization. Fiona Doetsch, Lee Rubin, and Megan Munsie bring expertise in neural stem cells, iPSCs, and developmental biology to their new roles.
Researchers have discovered a crucial biological mechanism by studying mouse embryo development, revealing how placenta-derived factors promote the expansion of liver progenitor cells. The study uncovers the role of IL1α in enhancing organoid growth under hypoxic conditions.
Researchers analyzed brain tissue from individuals with severe Tourette syndrome and identified three key changes: altered gene activity, regulatory element modifications, and interneuron loss. These findings provide unprecedented insights into the disorder's biology and may explain why individuals experience involuntary movements and ...
Alice Rossi, Angeliki Spathopoulou, and Gareth D. Chapman received the ISSCR Outstanding Poster Award for their innovative work on quiescent neural stem cells, neural stem/progenitor cell populations, and epigenetic dysregulation in Tatton-Brown-Rahman-Syndrome.
Researchers have discovered that planarians can regenerate body parts and even grow new heads, reversing signs of aging such as lost neurons and muscle mass. This finding has implications for understanding age-related decline in mammals, including humans.
Researchers at Karolinska Institutet have developed a method to track the development of cells in the nervous system and inner ear. The technique, known as ectoderm barcoding, reveals that cells in the inner ear develop from two main types of stem cells.
A USC Stem Cell mouse study has identified shared genes involved in regenerating cells in the ear and eye, which could lead to new treatments for hearing and vision loss. The researchers discovered that inhibiting a specific protein, p27Kip1, can encourage regeneration in both organs.
Scientists have used a cryo-electron microscope to capture detailed images of glutamate molecules interacting with AMPA receptors, revealing the chemical flow that enables learning and thinking in brain cells. The findings could lead to the development of new drugs to treat conditions like epilepsy and intellectual disorders.
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
A new study suggests that menthol in electronic cigarettes may pose risks to a developing baby, inhibiting cell growth and increasing cell death. The researchers recommend discouraging the use of mentholated e-cigarettes during pregnancy until more research is conducted.
Researchers at the University of Houston College of Pharmacy have identified a potential therapeutic target to repair injured muscles. They discovered that fibroblast growth factor–inducible 14 (Fn14) plays a crucial role in regulating satellite cell stability and function, which are responsible for muscle growth, repair, and regenerat...
Researchers have identified a novel mechanism of intercellular communication involving mRNA transfer between different types of stem cells. This phenomenon enables cell fate conversion and reverts human pluripotent stem cells to an earlier embryonic stage.
A new method has been developed for engineering specific mtDNA deletions in human cells, providing a powerful tool to model disease-associated mtDNA deletions. This approach uncovers mechanisms of histiocytosis-associated neurodegeneration and investigates how mutant stem cells co-opt regeneration to make tumors grow.
A Stanford Medicine study reveals glucose plays a crucial role in tissue regeneration by binding to proteins that control gene expression. Researchers found that glucose levels increase significantly as cells differentiate, supporting the growth of specialized cells in various tissues.
A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.
Researchers have developed a way to activate adult stem cells from human bone marrow, enabling their expansion outside the body for use in bone marrow regeneration. The new method significantly improves transplant success rates for patients with genetic disorders or those who require a bone marrow transplant.
Researchers have identified a potential new gene target, FLT1, that could be edited to treat sickle cell disease by increasing fetal hemoglobin levels. The study found 14 new genetic markers associated with fetal hemoglobin production, which could help preserve the type of hemoglobin present at birth.
An international team of scientists has molecularly decoded blood stem cell differentiation pathways using state-of-the-art sequencing methods. They identified a crucial surface protein, PD-L2, which suppresses the immune response by preventing T cell activation and release of inflammatory substances.
Researchers at UC Santa Cruz engineered cellular models of embryos using CRISPR technology, allowing them to study early developmental stages without experimenting with actual embryos. The team found that 80% of stem cells organized into embryo-like structures, showcasing a remarkable collective behavior and molecular composition.
A team of scientists has successfully developed a novel platform for diabetes treatment utilizing bioink derived from pancreatic tissue and 3D bioprinting technology. The HICA-V platform replicates the structure and function of the human endocrine pancreas, supporting islet maturation and functional enhancement.
Researchers identified the prion protein as a key player in the progression of glioblastoma, a type of brain tumor. The study found that blocking the production of this protein using genetic editing reduced the ability of tumor stem cells to proliferate and invade tissues.
A University of Minnesota research team has been awarded a $3.8 million grant to develop a new cell therapy targeting Alzheimer's disease. The project aims to adapt cancer treatment techniques to create specialized immune cells that can clear harmful proteins from the brain.
A new stem cell therapy trial at UTHealth Houston aims to reduce neuroinflammation in patients with presymptomatic Alzheimer's disease. The study, which is sponsored by Weston Brain Institute, will enroll 12 patients and use PET imaging to determine whether stem cells reduce brain inflammation before symptoms develop.
Researchers have discovered a new diterpene-based drug that facilitates the repopulation of mature functional neurons in brain regions damaged by traumatic injuries. The study found that these new cells are integrated into neural circuits and develop functional characteristics similar to those eliminated by the injury.
Researchers have successfully developed lab-grown pig retinal organoids, which shared similarities with human retinal organoids. The study offers a promising approach to combatting retinal disease by testing 'human-equivalent' photoreceptors in pigs.
Researchers at MIT have devised a simplified process to convert skin cells directly into neurons, bypassing the stem cell stage and achieving yields of over 10 neurons from a single skin cell. This approach could potentially be used to treat patients with spinal cord injuries or diseases that impair mobility.
The PREMSTEM Conference will present cutting-edge research on neonatal brain repair, focusing on human mesenchymal stem cells as a potential therapy for preterm birth-related brain injury. Associate Professor Atul Malhotra's keynote address will highlight successes and lessons learned from his ongoing stem cell-based therapy trials.
A recent study published in Nature has identified specialized blood vessels and nitric oxide as crucial for stem cell survival and immune evasion. Hematopoietic stem cells that produce high levels of nitric oxide survive by manipulating the immune response, creating an 'immune-privileged' environment.
Researchers at MD Anderson have made significant breakthroughs in understanding pancreatic cancer's evolutionary process and developing new treatment strategies. They also discovered that surgical resection can enhance antitumor response in patients receiving immune checkpoint therapy for advanced kidney cancer.
The study highlights the role of the Nwd1 gene in liver disease and its potential as a therapeutic target. Mice with Nwd1 gene deletion exhibited liver pathologies mirroring MASH, including excessive lipid accumulation and increased ER stress.
Researchers found genetic changes in frequent blood donors that enable them to respond well to blood loss, promoting healthy stem cell growth. In contrast, preleukemic mutations associated with blood cancer were not favored by regular donation.
Researchers discovered a molecular switch, FLI-1, essential for blood stem cells to enter an activated state. Transiently producing FLI-1 in quiescent adult mobilized bone marrow stem cells activates them, improving their ability to expand and restore the blood cell supply in a new host.
Researchers at Wisconsin National Primate Research Center and Morgridge Institute for Research have developed a universal, small-diameter vascular graft using stem cell-derived arterial endothelial cells. The graft overcomes limitations of current clinical options, which include invasive procedures and limited donor availability.
A Phase 1 clinical trial is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson's disease, in which a patient's stem cells are reprogrammed to replace dopamine cells. The trial uses autologous stem cell transplantation, avoiding immunosuppressive treatments, and has enrolled three patients so far.
A recent study by Professor Mamas highlights the significant risk of cardiovascular diseases (CVD) in patients with cancer, particularly in aging populations. The review emphasizes the need for early diagnosis and regular monitoring to improve quality of life.
A new Northwestern Medicine study suggests that muscle injuries heal faster when they occur during the body’s natural waking hours. The findings could have implications for shift workers and may also prove useful in understanding the effects of aging and obesity.
Researchers at USC Stem Cell discovered a gene called KCTD20 that suppresses glutamate toxicity, leading to enhanced tau protein clearance. This approach offers a promising therapeutic strategy for patients with tau-related neurodegenerative diseases, including Alzheimer's disease.
A new stem cell therapy, CALEC, has been successfully tested on 14 patients with blinding cornea injuries, achieving a high proportion of complete or partial success rates. The treatment was found to be safe and effective, with no serious events occurring in either the donor or recipient eyes.
Researchers from UC San Diego will present cutting-edge solutions to address global challenges such as climate change and human longevity. The event features a film premiere and thought-provoking presentations on topics like capturing carbon and democratizing health data.
BaCell 3D conference to feature original research in organoids and regenerative medicine, published in Stem Cell Reports. The International Society for Stem Cell Research (ISSCR) partners with Stem Cell Reports to promote discoveries with potential to transform regenerative medicine.
A research team at the University of Cologne has identified a specific form of the tau protein, 1N4R, responsible for mediating toxic effects of protein clumps in human brain cells. This breakthrough understanding could lead to new treatments for Alzheimer's disease.
A new stem cell transplant treatment has shown promising results in clearing clinical safety hurdles for the treatment of wet age-related macular degeneration. The treatment involves removing abnormal blood vessels and transplanting stem cell-derived retinal cells to replace damaged or lost retinal cells.
Researchers at Osaka Metropolitan University have successfully generated feline embryonic stem cells, a major breakthrough for veterinary regenerative medicine. The high-quality stem cells can differentiate into various cell types and be transplanted to restore internal damage.
Researchers at UCSF have discovered that human lung tissue contains hematopoietic stem cells (HSCs) capable of producing red blood cells, platelets, and immune cells. The finding suggests the lungs could be a potent source for life-saving stem cell transplants, particularly for patients with leukemia.
Researchers combine radiation with a plant-derived compound to combat glioblastoma, forcing cancer cells into a dormant state. The approach significantly slows tumor growth and improves survival in mice models, offering a potential new avenue for combating this deadly form of brain cancer.
A new study has identified two cell types with distinct biological properties that respond differently to treatment after acquiring the same mutation. Understanding these differences is crucial for developing personalized therapies and preventing aggressive forms of cancer.
A Mount Sinai-led research team has identified stem cell populations and mechanisms underlying age-related degeneration in meibomian glands, which secrete lipid-rich meibum to prevent tear evaporation. The findings suggest that targeting Hh and EGFR signaling could be a potential therapeutic option for evaporative dry eye disease.
Researchers at Helmholtz Munich identified distinct subtypes of white matter astrocytes, including one that can multiply and support brain repair. These findings raise possibilities for regenerative medicine and therapies for brain injuries and neurodegenerative diseases.
A collaborative study reveals two distinct types of scarring, referred to as “hot” and “cold,” which require entirely different treatments for diseased hearts. The researchers found that hot fibrosis is driven by an immune response, while cold fibrosis is a self-maintaining process.
Researchers developed reprogrammed vascular endothelial cells that provide strong support for islets, allowing them to survive and reverse diabetes long-term. The study showed that mice transplanted with islet cells plus R-VECs regained normal blood glucose control after 20 weeks.
Dr. Yonatan Stelzer has made significant contributions to understanding epigenetic mechanisms and embryonic development, challenging conventional knowledge with innovative approaches. His research aims to establish fully data-driven quantitative models of spatiotemporal processes in mammals.
Researchers have discovered a novel gene therapy that can reverse conduction slowing and prevent cardiac arrhythmias by introducing the SCN10a-short gene into heart muscle cells. The treatment has shown promise in animal models and human cell studies, offering a potential solution for millions affected by arrhythmias worldwide.
Researchers discover that the gene HMGA1 'opens' regions of the genome to activate stem cell genes, leading to tumor development and progression. High levels of HMGA1 also allow mutant tumor cells to escape detection by immune cells.