Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
A new study has identified two cell types with distinct biological properties that respond differently to treatment after acquiring the same mutation. Understanding these differences is crucial for developing personalized therapies and preventing aggressive forms of cancer.
Researchers at Helmholtz Munich identified distinct subtypes of white matter astrocytes, including one that can multiply and support brain repair. These findings raise possibilities for regenerative medicine and therapies for brain injuries and neurodegenerative diseases.
A Mount Sinai-led research team has identified stem cell populations and mechanisms underlying age-related degeneration in meibomian glands, which secrete lipid-rich meibum to prevent tear evaporation. The findings suggest that targeting Hh and EGFR signaling could be a potential therapeutic option for evaporative dry eye disease.
A collaborative study reveals two distinct types of scarring, referred to as “hot” and “cold,” which require entirely different treatments for diseased hearts. The researchers found that hot fibrosis is driven by an immune response, while cold fibrosis is a self-maintaining process.
Researchers developed reprogrammed vascular endothelial cells that provide strong support for islets, allowing them to survive and reverse diabetes long-term. The study showed that mice transplanted with islet cells plus R-VECs regained normal blood glucose control after 20 weeks.
Dr. Gordon Keller's groundbreaking research on directed differentiation of human pluripotent stem cells has illuminated the path to transforming human health. His lab's world-first discovery and pioneering efforts have pushed the boundaries of what is possible, offering hope for regenerating heart, liver, and blood cells.
Dr. Yonatan Stelzer has made significant contributions to understanding epigenetic mechanisms and embryonic development, challenging conventional knowledge with innovative approaches. His research aims to establish fully data-driven quantitative models of spatiotemporal processes in mammals.
Researchers have discovered a novel gene therapy that can reverse conduction slowing and prevent cardiac arrhythmias by introducing the SCN10a-short gene into heart muscle cells. The treatment has shown promise in animal models and human cell studies, offering a potential solution for millions affected by arrhythmias worldwide.
Researchers discover that the gene HMGA1 'opens' regions of the genome to activate stem cell genes, leading to tumor development and progression. High levels of HMGA1 also allow mutant tumor cells to escape detection by immune cells.
Dr. Paola Arlotta's groundbreaking research on stem cell-derived brain organoids has redefined human brain development and neurological disease understanding. Her work provides access to the complexities of developing human brains, making her a deserving recipient of the ISSCR Momentum Award.
Researchers discovered a novel mechanism of intercellular communication through mRNA transfer between stem cells, allowing for biologically significant effects such as cell fate conversion and pluripotent state maintenance.
The University of Texas MD Anderson Cancer Center received nearly $23 million in CPRIT funding to advance cancer research, translational science, and clinical trials. The funding will support the recruitment of a first-time tenure-track faculty member and enhance the understanding of cancer biology.
Researchers created a computational method to track brain cell development over time, capturing unlabeled cells and fine structures in live cultures. The algorithm achieved high precision rates for detecting individual neurons, paving the way for studying neurological diseases and developing therapies.
Researchers found that a rare genetic syndrome causes different damage mechanisms in male and female brains, affecting neurogenesis and energy production. The study suggests that the ADNP protein plays a crucial role in brain development and aging, with distinct functions in males and females.
A team from Tokyo Metropolitan University has successfully implanted myoblasts onto healthy muscle in mice using an extracellular matrix scaffold. This breakthrough treatment could treat ageing-related muscular atrophy without scarring, offering a promising avenue for regenerative medicine.
Researchers have discovered Random Antimicrobial Peptide Mixtures (RPMs) as a promising non-antibiotic antimicrobial agent for cultured meat production. RPMs successfully eliminate bacterial contamination without harming stem cell viability or contributing to antibiotic resistance.
The study reveals that the interplay between ERK/MAPK and IFN-gamma signaling is essential for preserving intestinal stem cells during aging. The researchers found that maintaining a balance between these signaling pathways is critical for supporting stem cell maintenance, while also driving age-related changes in differentiated cells.
Researchers at Fujita Health University have developed a novel therapy using mesenchymal stem cells to treat inflammatory eye diseases, reducing inflammation and promoting tissue repair. The study found that adMSC injections effectively reduced inflammation in mice with GVHD without long-term complications.
Researchers found that glioblastoma stem cells are co-localized with myeloid-derived suppressor cells, promoting tumor growth and aggressiveness. The study identified key molecules, such as IL-6 and IL-8, that attract and activate MDSCs, providing new potential therapeutic targets.
A University of Ottawa neuroscientist has led a Canadian research team to discover how neural stem cells integrate signals from different cell types and decode them. The study found that low daughter cell numbers trigger activation, while high numbers keep them in quiescence, offering new insights into cellular relationships and potent...
The ISSCR International Symposium will commemorate the 20th anniversary of iPSC discovery, highlighting breakthrough achievements and new research advances. The event aims to celebrate the transformative power of scientific curiosity and its potential to unlock cures for previously untreatable diseases.
The Terasaki Institute recognizes Dr. Cato Laurencin's groundbreaking contributions to regenerative engineering, while Dr. Jun Chen is recognized for his innovative technologies in soft bioelectronics and magnetoelastic materials.
Researchers at FAU's Schmidt College of Medicine will explore the use of genetically engineered cells to treat degenerative diseases, with a focus on understanding how hypoxic conditions drive cellular transformation. The study aims to identify novel pathways controlling this process and develop strategies for engineering more complex ...
Researchers at University of California San Diego have discovered the transformation process of healthy stem cells to cancer stem cells in oral cancer. By activating YAP and HPV oncogenes, normal stem cells are reprogrammed into cancer cells, leading to early-stage tumor initiation.
A potential new therapy, CT-179, effectively targets tumor cells and disrupts cancer stem cells, leading to improved treatments and increased survival rates. The novel drug, developed by Curtana Pharmaceuticals, may bring new efficacy to brain tumor therapy.
A study by Rutgers Health researchers found that brain immune cells from people with a high genetic risk for alcohol use disorder behave differently than cells from low-risk individuals when exposed to alcohol. This discovery could help explain why some people are more susceptible to developing drinking problems.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have developed a platform that emulates human marrow's native environment. The device, called a bone marrow-on-a-chip, generates functional human blood cells and models the immune system's response to infections, paving the way for advanced drug dev...
Researchers successfully created a bi-paternal mouse by modifying genes involved in reproduction. The mice that reached adulthood exhibited altered growth and shortened lifespan, but could potentially lead to new therapeutic strategies for imprinting-related diseases.
The collaboration aims to develop advanced 3D mini-brain models for replicating human brain architecture, enabling researchers to explore neurological diseases and screen drug candidates. The platform offers a high-throughput screening method for rapid testing of potential drug candidates.
Dana-Farber investigators pinpoint the importance of cell type and tumor microenvironment in determining DLI response. Patients who responded to DLI had distinct cellular populations in their bone marrow, which may indicate 'hot' or 'cold' forms of AML.
The ISSCR has appointed Lizhong Liu, Kate MacDuffie, and Mubeen Goolam as the third cohort of Lawrence Goldstein Science Policy Fellows. The fellows will serve for three years and focus on science policy and advocacy work in regenerative medicine.
Researchers have developed a novel stem cell treatment strategy for leptomeningeal brain metastasis, a severe form of metastatic brain cancer. The new therapy, which combines allogeneic dual stem cells with oncolytic herpes simplex virus and single chain variable fragment of anti-PD-1, shows promise in preclinical models.
Researchers analyzed 101 Chinese AML samples and identified three subtypes with different molecular characteristics and clinical outcomes. The study also found potential drug combinations that could improve treatment efficacy for subtype S-II&III patients who benefited from allogenic haematopoietic stem cell transplantation.
A new imaging technique provides unparalleled view of bone marrow's intricate structure, focusing on LepR+ stromal cells. The technique combines tissue clearing and high-resolution confocal imaging, offering new insights into stem cell niches and skeletal tissue interactions.
Researchers found that heart muscle cells can grow and survive in microgravity, suggesting a new approach to regenerating damaged hearts. The study uses cardiac spheroids to mimic the human heart structure and function, leading to increased survival rates and potential for improved cell therapy.
A study by researchers at Helmholtz Munich has discovered that ancient viral DNA elements are re-expressed in mammalian embryos, playing a crucial role in early development. The activation of these elements is conserved across species and provides opportunities for manipulating thousands of genes simultaneously.
A recent study from Memorial Sloan Kettering Cancer Center sheds new light on the heterogeneity of GBM tumors and the role of cancer stem cells in tumor growth. The research identifies six distinct transcriptional states, each with its own unique gene signature, and provides guidance for future research to develop targeted therapies.
A preclinical study by Weill Cornell Medicine investigators found that an immune protein called the inflammasome helps prevent blood stem cells from becoming malignant by removing certain receptors and blocking cancer gene activity. The study suggests that targeting the earliest stages of cancer may lead to new therapies.
Stem Cell Reports, an open access journal of the International Society for Stem Cell Research, is seeking highly motivated early career scientists to join its Early Career Scientist Editorial Board. The selected members will have the opportunity to shape the journal's editorial direction and promote stem cell research.
Researchers developed an AI-powered technology that transforms low-resolution, label-free images into high-resolution, virtually stained ones without fluorescent dyes. This innovation delivers stable and accurate cell visualization, overcoming limitations of traditional imaging methods.
Researchers identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder. MDPL syndrome is characterized by premature aging of mesenchymal stem cells, which can form tissues like bone and fat.
Janet Rossant takes over as Editor-in-Chief of Stem Cell Reports, aiming to publish high-quality primary research articles and commentaries that shape the field of stem cell science. She brings extensive experience and scientific expertise to the position, previously serving as ISSCR President.
A three-drug cocktail of drugs has been identified as a potential booster of CAR-T cancer therapy by researchers at the University of North Carolina. The cocktail preserves a critical cell subset called T-memory stem cells, which are crucial for long-term persistence of CAR-T cells.
A USC Stem Cell study found that the mammalian outer ear evolved from cartilaginous gills in fishes and marine invertebrates. The research used gene control elements to show a connection between gill and ear development.
Researchers at UCSF have discovered a new type of stem cell in the young brain that can form cells found in tumors, shedding light on how adult brain cells grow and develop into deadly brain cancers. The study provides a comprehensive roadmap for understanding healthy brain development, which could lead to better treatments for conditi...
A study suggests targeting endocan, a protein produced by endothelial cells in blood vessels, could slow tumor growth and make glioblastoma more vulnerable to existing treatments. The discovery may lead to new strategies to combat glioblastoma, which has an average lifespan of just 12-15 months.
Researchers found that injecting infarcted pig hearts with specially bioengineered cells significantly decreased the infarct area and improved heart function. The therapy worked by stimulating the proliferation of endogenous pig cardiomyocytes, which had previously been unable to divide in adult hearts.
Organoids, derived from stem cells, closely mimic human tissue for biomedical research and drug testing. Standardization is crucial for generating reliable results in organoid construction, requiring approved operating procedures and informed consent from donors.
A new study has found HSV-1 proteins embedded in Alzheimer's brains, linking the virus to tau protein changes. Researchers suggest that inhibiting viral activity or modifying the brain's immune response could slow or stop Alzheimer's progression.
Scientists cultivate stable tumor organoids directly from blood samples of breast cancer patients, revealing a molecular signaling pathway that ensures cancer cell survival and resistance to therapy. The team develops an approach to specifically eliminate these tumor cells in lab experiments.
Dr. Cathy Barr's groundbreaking research sheds light on the genetic foundations of conditions including depression, ADHD, reading disabilities, and Tourette syndrome. Her work has the potential to lead to more targeted treatments and reduce stigma around psychiatric disorders.
Researchers from Korea University have developed a groundbreaking technique to transform fibroblasts into mature cardiomyocytes, holding promise for regenerative medicine in treating cardiovascular disease. The method combines fibroblast growth factor 4 (FGF4) with vitamin C to accelerate cell maturation and enhance function.
A new method has been developed to create motor neurons from stem cells taken directly from ALS patients, allowing for fast and individualized drug testing. The cultured ALS motor neurons had increased susceptibility to cell death, underscoring the utility of this system to identify potential drugs.
A Phase I clinical trial demonstrated long-term safety and feasibility of neural stem cell transplantation for treating chronic spinal cord injuries. Two patients showed durable evidence of neurological improvement with increased motor and sensory scores.
A preclinical study suggests the experimental compound K884 can restore lost muscle function in Duchenne muscular dystrophy (DMD) patients by strengthening muscle repair. The drug targets specific enzymes, allowing muscle stem cells to develop into functional tissue.
A team of experts has discovered that the ARID1A gene regulates a critical genetic program for cell migration, with ZIC2 identified as a crucial regulator in this process. This study expands our understanding of craniofacial development and provides valuable insights into the genetic causes of congenital diseases.
Research found that intermittent fasting inhibits hair growth in mice by causing oxidative stress on stem cells. A clinical trial showed a similar effect in humans, with a 18% reduction in hair growth speed.
Researchers at the University of Bergen have developed mini-brains that can study disease processes caused by mitochondrial failure, potentially leading to new therapies for epilepsy and other brain disorders. The mini-brains offer a realistic model for exploring complex disease processes and testing treatment strategies.
The 2025 Gottfried Wilhelm Leibniz Prizes were awarded to four female and six male researchers, with two working in the humanities and social sciences, four in life sciences, three in natural sciences, and one in engineering sciences. The winners received €2.5 million each to fund their research for up to seven years.
Researchers found that prenatal exposure to Akkermansia muciniphila increased offspring's stem cell activity, leading to less anxiety and faster recovery from colitis. Postnatal exposure did not replicate these effects. The study suggests microbiome-based intervention strategies may improve child health.