Articles tagged with Stem Cell Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have successfully transplanted human embryonic stem cell-derived retinal organoid sheets into monkeys with macular holes, resulting in graft survival and maturation of light-detecting cells. The study suggests that this method could become a practical treatment option for difficult macular hole cases.
The ISSCR 2025 Annual Meeting will bring together stem cell scientists from diverse backgrounds to share knowledge and collaborate on innovative research. Scientists can submit abstracts by January 21, 2025, for oral presentations and qualify for awards.
A recent study from Japan investigates the impact of PAI-1 4G/5G polymorphism on thrombotic and inflammatory responses in Japanese patients with COVID-19. The study reveals that the 4G allele is linked to fibrinolysis inhibition and thrombosis risk, while the 5G allele promotes enhanced fibrinolysis and active cytokine responses.
Researchers identified a crucial protein, TIMP3, overproduced in AMD and found that blocking its activity can reduce drusen formation, suggesting a promising treatment strategy. The study offers new avenues for preventing AMD and improving the lives of millions affected by this disease.
A retrospective analysis of over 2,600 patients found that Black children were more likely to suffer severe graft-versus-host disease but overall survival rates improved across all racial groups. The study suggests that cord blood transplants are a vital lifeline for many patients and improve care for those without a matched donor.
Researchers found that low Wnt signaling levels regulate NPC self-renewal, while higher levels initiate differentiation into mature kidney cell types. The studies also reveal the role of beta-catenin in aggregating NPCs to form early kidney structures.
Researchers identified a molecular mechanism that controls embryonic diapause in humans, allowing cells to temporarily slow down development. This dormant state is characterized by reduced cell division and slower development, and can be reversed when the mTOR pathway is reactivated.
Researchers at University of California - San Diego have discovered that Crohn's disease consists of two distinct molecular subtypes, each exhibiting unique patterns of genetic mutation and cellular phenotypes. This finding could lead to more effective management strategies, with therapies tailored to specific subtypes.
A study found that children with Down's syndrome have an elevated number of red blood cells, which increases their risk of developing leukemia. The extra chromosome 21 alters DNA packing and gene regulation, contributing to the development of leukemia.
Researchers at Johns Hopkins University mapped variation in human stem cells, revealing unique developmental patterns and gene expression traits that modify conserved steps. The findings may aid personalized regenerative therapies and advance understanding of cellular variation in humans.
Researchers found that maintaining optimal levels of DEAF1 is crucial for muscle repair and regeneration, and that restoring balance with DEAF1 may counteract some effects of aging on muscle tissue. This could lead to improved treatments for sarcopenia and cachexia, conditions affecting millions of older adults and cancer patients.
Researchers have established a unique resource of induced pluripotent stem cells from centenarians and their offspring to better understand human longevity and aging. The largest library of iPSCs allows for studies on healthy aging, disease resistance, and the development of novel therapeutics for aging-related diseases.
A new analytical tool called PATH can quantify tumor cell plasticity, which is a key characteristic of cancer that leads to treatment resistance and metastatic spread. Researchers used PATH to analyze tumor samples from animal models and human patients, revealing new details of how tumors exploit plasticity to spread.
Researchers found that low gravity conditions in space weaken and disrupt the normal rhythmic beats of human bioengineered heart tissue samples. The tissues on the International Space Station beat about half as strong as those on Earth, and developed irregular beating patterns that can cause a human heart to fail.
A study by Kumamoto University researchers reveals that ApoE plays a crucial role in promoting hematopoietic stem cells to produce more red blood cells in response to acute anemia. This mechanism differs from the previously known pathway and may pave the way for new treatments for patients with severe anemia.
Researchers at Kyoto University have developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip that mimics in vivo renal physiology. This model exhibits enhanced expression and polarity of essential renal transporters, making it a powerful tool for assessing drug transport and nephrotoxicity.
Researchers identified key control sites regulating gene expression in cells, including those controlling ancient viral sequences. Mutating these sites caused defects in cell differentiation and survival, as well as spurious activation of genes across the genome.
A Purdue team has discovered a protein called CrHAM that regulates meristem indeterminacy, preventing stem cells from differentiating into male organs. This discovery provides insights into the stem cell proliferation process and its role in maintaining gender balance in vascular plants.
Researchers are decoding genetic mutations in high-risk genes for neurodevelopmental and psychiatric disorders, including schizophrenia and depression. A new collaborative project aims to characterize the genetic origins of these disorders using human stem cells.
Researchers at NTU Singapore and Oxford have identified a new process called nucleophagy that helps cells remove harmful DNA-protein lesions, promoting genetic material stability and cell survival. This discovery may improve cancer treatment outcomes for patients with colorectal cancer.
The Harvard team successfully recreated the satellite cell niche using 3D organoid culture techniques, generating stem cells that closely resemble native adult stem cells. These cells can engraft, repopulate the stem cell niche, persist long-term, and regenerate muscle after repeated injury.
A new study published in the journal JCI Insight found that male mice fed high-cholesterol diets have increased cardiovascular disease risk in their female offspring. The researchers used a novel method to study sperm small RNA and discovered altered molecules that affect gene expression in early embryonic stem cells.
Researchers at Iowa State University have discovered a potential breakthrough in producing lab-grown blood stem cells by pausing the initial activation of inflammatory signals. This allows for the production of hundreds of functional stem cells, which could replace bone marrow transplants for blood disorders such as leukemia and anemia.
Scientists identified key changes in chromosome structure and gene expression that affect stem cell function during aging. Blocking a specific gene, ced-6, triggered stem cell exhaustion at any age, indicating a general process that maintains balance when proliferation is too high.
Researchers will combine stem cell therapy with brain-computer interfaces to restore function to patients with brain damage. The goal is to create bidirectional connections between cultured brain cells and the living human brain.
Researchers have identified key cellular interactions and microenvironments that contribute to the development of chronic kidney disease (CKD) after acute kidney injury (AKI) in mice. The study, published in Nature Communications, provides new insights into how damaged cells interact within disease-promoting microenvironments.
Researchers at the University of Illinois Chicago have identified a cellular pathway essential to obesity-induced atrial fibrillation. Blocking NOX2, an enzyme that produces reactive oxygen species, may prevent and reverse changes in heart structure and function caused by high-fat diets.
Scientists have discovered that epigenetic changes can reprogram astrocytes into brain stem cells, which can potentially be used to replace damaged nerve cells in regenerative medicine. This breakthrough is made possible by the methylation of genetic material, allowing these special astrocytes to acquire stem cell properties.
Researchers at Osaka Metropolitan University have successfully generated high-quality feline induced pluripotent stem cells (iPSCs) without a genetic footprint. These cells exhibit properties similar to human iPSCs and can differentiate into various cell types, making them a promising tool for veterinary regenerative medicine research.
Researchers found that inflammation in the gut affects ISCs' regenerative capacity even after resolution of inflammation. The study used cellular and animal models to show that exposure to inflammation reprograms the epigenome, leading to reduced regeneration.
Melbourne researchers have developed a breakthrough in creating lab-grown human blood stem cells, which can be used to treat childhood blood disorders. The cells closely mimic those found in the human embryo and can create specific matched blood cells for transplantation, reducing complications and addressing donor shortages.
Researchers developed AI tool AINU to differentiate cancer cells from normal cells and detect early stages of viral infection. The tool scans high-resolution images of cells at nanoscale resolution, enabling it to detect subtle changes in cell structure that are too small for human observers.
A recent study found that the epigenetic age of a tissue is influenced by the frequency and activity of its stem cells. Stem cells in skin and intestine had a higher rate of division, resulting in a younger epigenetic age compared to those in muscle and blood.
Kumamoto University researchers discovered HMGA2's crucial role in regulating stress responses in hematopoietic stem cells. The gene enhances blood cell production recovery under stressful conditions, such as chemotherapy and infections.
A new study reveals that fasting helps regenerate and heal intestinal injuries, but also increases the risk of developing early-stage intestinal tumors in mice. The researchers identified a pathway enabling this enhanced regeneration, which is activated during refeeding after fasting.
A team led by Harvard's Ryan Flynn has discovered the mechanism of how RNA is chemically linked to N-glycans, proving the existence of glycoRNAs. This finding broadens the scope of known glycoconjugates and opens new avenues for research into glycoRNA biology.
A study of over 900 children with autism spectrum disorder found that brain overgrowth is associated with increased social and communication symptoms. The research used MRI brain images and mini-brain experiments to show that enlarged brains are linked to altered Ndel1 enzyme activity, potentially affecting brain development.
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
Researchers have identified multipotent stem cells in sea anemones that are regulated by highly conserved genes, which could provide insights into human aging. These stem cells express genes like nanos and piwi, essential for germ cell formation, and may hold the key to understanding the potential immortality of sea anemones.
Researchers discovered that blocking Cxcr4 in mice reduced white fat tissue, while estrogen therapy could be effective with lower doses. The study offers promising avenues for understanding healthy and unhealthy fat tissue development.
A new study reveals that zebrafish spinal cords regenerate by leveraging the survival and adaptability of severed neurons, rather than relying on stem cells. The research identifies genetic targets to promote this type of plasticity in humans and other mammals.
Texas A&M researchers are investigating the use of extracellular vesicles to deliver immune-suppressing proteins, potentially reducing the immune system's attack on insulin-producing beta-cells. The goal is to develop a novel treatment for type 1 diabetes, which currently has only lifelong insulin therapy as an approved option.
A new technique developed by McGill researchers allows for precise targeting of stem cells to become specific cell types, such as bone or fat cells. This breakthrough has the potential to lead to new stem cell treatments for various diseases, including multiple sclerosis, Alzheimer’s and Type 1 diabetes.
Researchers at Florida State University have shown potential of a new treatment for pediatric brain cancer by enhancing natural killer immune cells to improve their ability to attack the disease. The study, published in Bioactive Materials, provides a critical part in addressing a major clinical need for children with brain cancer.
Researchers at Albert Einstein College of Medicine discover a new way to improve HSC mobilization for clinical use. Trogocytosis, a mechanism where one cell type extracts membrane fractions from another, plays a role in regulating immune responses and cellular systems.
Researchers at the Centre for Genomic Regulation have discovered a treatment that speeds up the production of high-quality pluripotent stem cells in mice. The finding uses interferon gamma to accelerate cellular reprogramming, paving the way for improved disease modeling and personalized treatments.
Researchers found COVID-19-related diarrhea mechanisms using human stem cells and enteroids, a single layer of cells in a petri dish. The study suggests testing inhibitors of inflammation may help treat COVID-19 diarrhea, linking it to long COVID symptoms.
Researchers at the University of Helsinki have created cells that can't grow uncontrolledly, which could lead to new and safer cell therapies for hereditary diseases, myocardial infarction, and other conditions. The innovation uses thymidine supplementation to regulate cell division, eliminating the risk of cancer.
Researchers discovered that transferring regenerative genes from simple organisms into fruit flies can suppress age-related issues and promote greater intestinal stem cell division. This breakthrough has implications for developing new strategies to rejuvenate stem cell function and extend healthy lifespans, particularly in humans.
Researchers discovered a new small molecule, SR-18292, that increases fetal hemoglobin production and reduces sickled red blood cells in mice with sickle cell disease. The study suggests that combining SR-18292 with hydroxyurea could provide a vital new treatment option for patients who don't respond well to traditional treatments.
A pivotal study reveals the genetic interplay that maintains stem cell balance in Solanaceae plants, uncovering receptor compensation mechanisms. Understanding these mechanisms is crucial for improving crop resilience and productivity, providing new perspectives for crop improvement and innovative approaches to agriculture.
Researchers at the University Hospital Bonn have established a highly efficient and cost-effective way to generate functional endothelial cells from human induced pluripotent stem cells (hiPSCs) for tests in cell culture dishes. The new method delivers endothelial cells more quickly, requires fewer additives, and is highly reproducible.
Researchers found a strikingly similar pluripotency gene network across jawless and jawed vertebrates, suggesting a common evolutionary origin. The study reveals that the loss of the pou5 gene in lampreys' neural crest cells may have limited their ability to form cell types found in jawed vertebrates.
A recent paper surveys advances in diabetes pathogenesis and treatment, highlighting the role of genes, environmental factors, and social determinants. The study suggests that understanding these dynamics is key to developing targeted interventions to reduce diabetes risk and manage its complications.
Researchers found that a cancer drug can restore phagocytosis, a process crucial for brain health, in individuals with Rett syndrome by targeting microglia. The study highlights the potential therapeutic target of microglia in neurological conditions and may lead to new treatments.
Researchers identified genetic and metabolic characteristics of leukaemic stem cells, including a specific iron utilisation process that can be blocked to kill these cells without harming healthy ones. This breakthrough paves the way for new therapeutic strategies to combat leukemia.
Some private UK biobanks are marketing umbilical cord blood banking services as a way to protect children's future health, claiming it can treat over 80 conditions. However, regenerative medicine experts say these claims are misleading and based on unrealistic applications.
Researchers developed core-shell microfibrous scaffolds that excel in rotator cuff repair, restoring natural morphology and mechanical properties. The acellular, in situ tissue engineering technology harnesses stem cell regenerative abilities to provide robust biological regeneration without cell seeding.
Researchers have discovered that SARS-CoV-2 can infect more types of lung cells than previously thought, including those without known viral receptors. The study also found that the lung can independently muster an inflammatory antiviral response without immune system help when exposed to the virus.
Researchers developed a preclinical model that shows knocking out VPS35 leads to alpha-synuclein aggregate accumulation, similar to human Parkinson's. The study also discovered a potential new strategy for detecting the disease using autofluorescence technology.