Researchers report the use of hyperpolarized 13C magnetic resonance imaging (HP 13C-MRI) to monitor the conversion of 13C-labeled pyruvate into lactate in seven breast cancer patients, ages 49-76 years, finding lactate formation to be associated with higher tumor grade and with expression of the hypoxia indicator HIF1α and the pyruvate transporter MCT1 and suggesting the feasibility of HP 13C-MRI for noninvasive characterization and monitoring of breast tumors.
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Article #19-13841: "Imaging breast cancer using hyperpolarized carbon-13 MRI," by Ferdia A. Gallagher et al.
MEDIA CONTACT: Ferdia A. Gallagher, University of Cambridge and Cancer Research UK, UNITED KINGDOM; tel: +44-1223-746438; e-mail: < fag1000@cam.ac.uk >; Ramona Woitek, University of Cambridge, UNITED KINGDOM; tel: +44-751-752-6738; e-mail: < rw585@cam.ac.uk >; Kevin M. Brindle, University of Cambridge and Cancer Research UK, UNITED KINGDOM; tel: +44-1223-769500; e-mail: < kmb1001@cam.ac.uk >
Proceedings of the National Academy of Sciences