Researchers synthesized the genome of the Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV), a highly pathogenic virus in pigs, and found that it efficiently replicated in various mammalian cell lines, including human liver, intestinal, and rectal cancer cells, as well as in airway and intestinal cells isolated from human donors, suggesting that SADS-CoV has a broad host range with potential human susceptibility to infection, according to the authors.
Article #20-01046: "Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection," by Caitlin E. Edwards et al.
MEDIA CONTACT: Ralph S. Baric, University of North Carolina at Chapel Hill, NC; tel: 919-966-3895; e-mail: rbaric@email.unc.edu
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Proceedings of the National Academy of Sciences