A research team led by Dr. Tetsuya Muramoto from the Faculty of Science at Toho University has demonstrated the mechanisms by which periodic chemical signal frequencies in cells regulate gene expression via transcription factors and influence the cell fate determination processes. This groundbreaking revelation was made using optogenetic technology, which facilitates the manipulation of biological phenomena using light. Their findings were recently published in the Development journal on January 14, 2025.
Key Points:
Journal:
Development (January 14, 2025)
Article Title:
Optogenetic Control of cAMP Oscillations Reveals Frequency-Selective Transcription Factor Dynamics in Dictyostelium
Authors:
Kensuke Yamashita, Kazuya Shimane, Tetsuya Muramoto*
DOI:
10.1242/dev.204403
Development
Experimental study
Cells
Optogenetic control of cAMP oscillations reveals frequency-selective transcription factor dynamics in Dictyostelium
14-Jan-2025
The authors declare no conflicts of interest associated with the article.