Kansas City, Mo., March 22, 2022 – BioMed Valley Discoveries (BVD), a clinical-stage biotechnology company, announced today they will present four posters at the upcoming American Association for Cancer Research (AACR) Annual Meeting, taking place April 8-13, 2022, in New Orleans, Louisiana. All four posters focus on the continued development of ulixertinib (BVD-523), the first-in-class and best-in-class ERK1/2 inhibitor. In addition, two collaborators will present additional data on ulixertinib.
BVD Poster Presentation Details:
Abstract Number: 415
Title: The characterization of in vitro models demonstrating a significant delay of acquired resistance to ulixertinib (ERK1/2)
Date/Time: Sunday, April 10, 2022 1:30 PM – 5:00 PM
Session: Cancer Drug Resistance and Reversal of Resistance
Location: New Orleans Convention Center, Poster Section 25
Abstract Number: 404
Title: Identification of combination partners to combat acquired resistance to ulixertinib (ERK1/2 inhibitor) using transcriptomics
Date/Time: Sunday, April 10, 2022 1:30 PM – 5:00 PM
Session: Cancer Drug Resistance and Reversal of Resistance
Location: New Orleans Convention Center, Poster Section 25
Abstract Number: 1057
Title: Significant efficacy demonstrated with the combination of ulixertinib (ERK1/2 inhibitor) and CDK4/6 inhibitors in MAPK altered models
Date/Time: Monday, April 11, 2022 9:00 AM - 12:30 PM CST
Session: Combinations
Location: New Orleans Convention Center, Poster Section 21
Abstract Number: 4022
Title: ERK1/2 inhibitor ulixertinib demonstrates activity in atypical (non-V600) BRAF mutant models
Date/Time: Wednesday, April 13, 2022 9:00 AM – 12:30 PM
Session: Molecular Pharmacology
Location: New Orleans Convention Center, Poster Section 26
Collaborator Poster Presentation Details:
Abstract Number: 5221
Title: The first-in-class ERK inhibitor ulixertinib (BVD-523) shows activity in MAPK-driven pediatric low-grade glioma models as single agent and in combination with MEK inhibitors or senolytics
Session: Pediatric Cancer: Clinical Investigations
Location: E-Poster Website
Abstract Number: 5333
Title: Pancreatic cancer enhances HER2 signaling through DUSP6 to circumvent therapeutic MAPK inhibition
Session: Drug Resistance
Location: E-Poster Website
Abstracts and full session details are currently available on the AACR meeting website . Posters will be available online at www.biomed-valley.com/news/#events-presentations following the presentations.
About Ulixertinib (BVD-523): Ulixertinib is a first-in class and best-in class small molecule inhibitor of extracellular signal-regulated kinase (ERK) family kinases (ERK1 and ERK2) that is being developed as a novel anti-cancer drug. ERK kinases are downstream components of the mitogen-activated protein kinase (MAPK) signaling cascade (RAS-RAF-MEK-ERK). Ulixertinib has demonstrated promising early efficacy for patients with tumors harboring alterations in the MAPK pathway, including atypical (non-V600) BRAF alterations, for which there are currently no approved targeted agents.
About BioMed Valley Discoveries (BVD): BioMed Valley Discoveries is a clinical stage biotechnology company focused on addressing unmet medical needs in a variety of therapeutic and diagnostic areas. In addition to the ERK inhibitor, BVD’s portfolio includes an oncolytic bacteria that has completed enrollment for a Phase I study, and two early-stage antibodies targeting the tumor microenvironment.
Operating since 2007, BioMed Valley Discoveries was established by Jim Stowers Jr., founder of the asset management firm American Century Investments , and his wife Virginia, to advance new medical innovations to improve the lives of patients with difficult-to-treat diseases. BVD is owned by a supporting organization of the Stowers Institute for Medical Research , a non-profit, basic biomedical research organization. Since 2000, the Stowers Institute has received over $1.5 billion in dividend payments from American Century. The Institute has invested a portion of its institutional funds in BVD, whose profits accrue to the benefit of the Institute. For more information, visit www.biomed-valley.com .
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