The authors show that biglycan is released during inflammation and goes on to act as an endogenous ligand of Toll-like receptor 4 in macrophages, increasing the macrophage responses and leading to rapid activation of signaling events. The researchers also show that mice lacking biglycan have a considerable survival benefit in experimental sepsis.
Title: The matrix component biglycan is proinflammatory and signals through Toll-like receptor-4 and -2 in macrophages
AUTHOR CONTACT:
Liliana Schaefer
University of Muenster, Muenster, Germany
Phone: 49-251-834-7525; Fax: 49-251-86-9550; E-mail: schaefl@uni-muenster.de
View the PDF of this article at: https://www.the-jci.org/article.php?id=23755
Journal of Clinical Investigation