Global democratic consensus on neuropathological disease criteria
In a Reflection and reaction article, a group of experts in Parkinson's disease outline an exciting and new initiative: to reach a democratic consensus on core definitions of the histopathological phenotype of Parkinson's disease by use of the worldwide web. The group, which includes experts from all over the world, have set up an interactive website to enable members of the neurology community to comment on and shape their proposed criteria. They state: "For the first time a global consensus on histopathological diagnostic criteria is within reach".
Why did NMDA antagonists fail?
NMDA receptor antagonists failed to show efficacy in clinical trials of stroke and traumatic brain injury. In a personal view, Chrysanthy Ikonomidou and Lechoslaw Turski hypothesise that glutamate may only be involved in the acute neurodestructive phase, after which it could resume its normal role, which may include promotion of neuronal survival. "The search for new neuroprotective therapies continues and drugs are entering clinical trials. The lessons learnt will hopefully guide these new developments", they conclude.
Review articles :
The neurology of mitochondrial DNA disease
Epilepsy in autism
Progressive supranuclear palsy: where are we now?
Friedreich's ataxia: treatment within reach
When should temporal lobe epilepsy be treated surgically?
The Lancet Neurology