A study suggests that a variant in the gene for the cardiac contractile protein troponin I, found in certain cases of sudden unexpected death in infants (SUDI), disrupts neonatal cardiac physiology by reducing the calcium-binding affinity of thin muscle filaments and can trigger arrhythimas in neonatal human cardiac muscle cells, suggesting that the variant might contribute to SUDI by causing sudden cardiac arrest.
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Article #18-19023: "In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants," by Sanam Shafaattalab et al.
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Proceedings of the National Academy of Sciences