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A fish that grows old in months reveals how kidneys age—and how a common drug protects them

01.26.26 | MDI Biological Laboratory

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Sodium-glucose linked transporter 2 (SGLT2) inhibition restores age-related loss of cell-cell communication in the aging killifish kidney
Cell-cell signaling networks in African turquoise killifish inferred using CellChat from single-nucleus RNA-sequencing data show ligand-receptor interactions between renal and vascular cell types. Overall, the total number of interactions declined with normal aging across all kidney cell types (left and center), but fish treated over time with SGLT2 inhibitors (right) maintained networks as they aged. Credit: Paulmann et al, 2025

Kidney International

10.1016/j.kint.2025.12.011

Experimental study

Animals

Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction

23-Dec-2025

HH received research support from AstraZeneca and lecture honoraria from Alexion, Bayer Inc., and Vifor Pharma. HS received honoraria for presentations from AstraZeneca and GSK and consulting fees from Techspert. The sodium-glucose linked transporter 2 inhibitor, dapagliflozin, was generously provided by AstraZeneca; however, the company had no role in study design, data collection, analysis, interpretation, or manuscript preparation. All the other authors declared no competing interests.

Additional Media

SGLT2 inhibitors maintain youthful capillaries
Blood vessels in a young African turquoise killifish (left) are dense and healthy. As the fish age (center) vessels become less dense, with fewer branches. Older fish treated over time with SGLT2 inhibitors (right) maintained youthful vasculature(Hannah Somers, Anastasia Paulmann, M.D., MDI Bio Lab) Credit: Hannah Somers, Anastasia Paulmann, M.D., MDI Biological Laboratory

Keywords

Biochemistry Cell Biology Computational Biology Diseases and Disorders Genetics Health and Medicine Human Health Life Sciences Molecular Biology Omics Pharmacology

Article Information

Journal
Kidney International
DOI
10.1016/j.kint.2025.12.011
Method of Research
Experimental study
Subject of Research
Animals
Article Publication Date
2025-12-23
Article Title
Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction
COI Statement
HH received research support from AstraZeneca and lecture honoraria from Alexion, Bayer Inc., and Vifor Pharma. HS received honoraria for presentations from AstraZeneca and GSK and consulting fees from Techspert. The sodium-glucose linked transporter 2 inhibitor, dapagliflozin, was generously provided by AstraZeneca; however, the company had no role in study design, data collection, analysis, interpretation, or manuscript preparation. All the other authors declared no competing interests.

Contact Information

Fred Bever
MDI Biological Laboratory
fbever@mdibl.org

Source

Original Source
https://mdibl.org/press-release/a-fish-that-grows-old-in-months-reveals-how-kidneys-age-and-how-a-common-drug-protects-them/

How to Cite This Article

APA:
MDI Biological Laboratory. (2026, January 26). A fish that grows old in months reveals how kidneys age—and how a common drug protects them. Brightsurf News. https://www.brightsurf.com/news/1ZZGRQR1/a-fish-that-grows-old-in-months-reveals-how-kidneys-ageand-how-a-common-drug-protects-them.html
MLA:
"A fish that grows old in months reveals how kidneys age—and how a common drug protects them." Brightsurf News, Jan. 26 2026, https://www.brightsurf.com/news/1ZZGRQR1/a-fish-that-grows-old-in-months-reveals-how-kidneys-ageand-how-a-common-drug-protects-them.html.