Analysis of cellular senescence, a stress response mechanism with anticancer, tissue remodeling, and aging implications, in the naked mole rat (Heterocephalus glaber) revealed that newborn naked mole rats exhibit developmental senescence in many tissues, including the hair follicle, nail bed, and skin dermis, whereas naked mole rat embryonic and skin fibroblasts exhibit oncogene-induced and DNA damage-induced senescence, suggesting that evolution of longevity does not eliminate cellular senescence, according to a study.
###
Article #17-21160: "Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence," by Yang Zhao et al.
MEDIA CONTACT: Vera Gorbunova, University of Rochester, NY; tel: 585-472-1234; e-mail: < vgorbuno@ur.rochester.edu >
Proceedings of the National Academy of Sciences