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Atomic resolution of the broad-spectrum antiviral drug cascade to facilitate the design of antiviral drugs

08.27.24 | PLOS

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Atomic resolution of the broad-spectrum antiviral drug cascade to facilitate the design of antiviral drugs
Bemnifosbuvir, a guanosine analogue, is in clinical trials against the Hepatitis C virus (HCV) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This compound undergoes a series of five cellular modifications to transform into its active triphosphate form, AT-9010. The rate-limiting step in the activation pathway involves the histidine triad nucleotide phosphoramidase (HINT1). Structural analysis reveals that HINT1, when complexed with the Bemnifosbuvir intermediate (AT-8003) Credit: François Ferron (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)

Atomic resolution of the broad-spectrum antiviral drug cascade to facilitate the design of antiviral drugs

In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology : http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002743

Article Title: The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

Author Countries : France, United States, Germany

Funding: see manuscript

PLOS Biology

10.1371/journal.pbio.3002743

Observational study

Cells

Competing interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: S.G., A.M. and J.P.S. are employees of ATEA Pharmaceuticals, Inc.

Keywords

Antivirals Drug Design

Article Information

Journal
PLOS Biology
DOI
10.1371/journal.pbio.3002743
Method of Research
Observational study
Subject of Research
Cells
COI Statement
Competing interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: S.G., A.M. and J.P.S. are employees of ATEA Pharmaceuticals, Inc.

Contact Information

Claire Turner
PLOS
biologypress@plos.org

How to Cite This Article

APA:
PLOS. (2024, August 27). Atomic resolution of the broad-spectrum antiviral drug cascade to facilitate the design of antiviral drugs. Brightsurf News. https://www.brightsurf.com/news/8OMD6YQ1/atomic-resolution-of-the-broad-spectrum-antiviral-drug-cascade-to-facilitate-the-design-of-antiviral-drugs.html
MLA:
"Atomic resolution of the broad-spectrum antiviral drug cascade to facilitate the design of antiviral drugs." Brightsurf News, Aug. 27 2024, https://www.brightsurf.com/news/8OMD6YQ1/atomic-resolution-of-the-broad-spectrum-antiviral-drug-cascade-to-facilitate-the-design-of-antiviral-drugs.html.