Researchers report that the small molecule DAPPD, which promotes phagocytosis of microglia cells in the brain, diminished amyloid deposition and improved cognitive function in transgenic mouse models of Alzheimer's disease; the results suggest that compounds countering neuroinflammation might represent a viable therapeutic strategy against neurodegenerative diseases, according to the authors.
Article #19-16318: "N,N?-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice," by Min Hee Park et al.
MEDIA CONTACT: Mi Hee Lim, Korea Advanced Institute of Science and Technology, Daejeon, SOUTH KOREA; e-mail: miheelim@kaist.ac.kr
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Proceedings of the National Academy of Sciences