A study including 1,110 people finds that a polymorphism affecting the CD300f immune receptor in microglial cells in the brain is associated with protection against major depressive disorder in women and that knocking out the immune receptor in female mice results in behavior consistent with major depressive disorder; the results suggest a role for microglia and their immune receptors in neuropsychiatric disorders, according to the authors.
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Article #19-11816: "CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness," by Natalia Lago et al.
MEDIA CONTACT: Hugo Peluffo, Institut Pasteur de Montevideo, URUGUAY; e-mail: hugo.peluffo@pasteur.edu.uy
Proceedings of the National Academy of Sciences