As hydrogel applications expand in bioengineering, drug delivery, wound healing and wearable devices, their strong swelling and uncontrollable degradation severely restrict long-term performance. Now, researchers from the State Key Laboratory of Supramolecular Structure and Materials at Jilin University, led by Professor Yunfeng Li, have presented a nanocolloidal hydrogel (NCG) that remains dimensionally stable and resists biodegradation for over six months. This work offers a clinically translatable platform that overcomes the swelling-driven failures of conventional hydrogels.
Why Nonswelling Hydrogels Matter
Innovative Design and Features
Applications and Future Outlook
This comprehensive study provides a blueprint for engineering next-generation hydrogels that combine long-term structural integrity with biofunctionality. It underscores the importance of nanoscale hydrophobic engineering in overcoming the classic swelling–degradation trade-off. Stay tuned for more translational advances from Professor Yunfeng Li’s group at Jilin University!
Nano-Micro Letters
Experimental study
Nonswelling Lubricative Nanocolloidal Hydrogel Resistant to Biodegradation
11-Jul-2025