Nonswelling lubricative nanocolloidal hydrogel resistant to biodegradation

Researchers have developed an injectable hydrogel that targets rapid localized increase in bone density. The results show a four- to five-fold increase in bone density in the legs of rats with bone loss. The study combines systemic osteoporosis drugs with local hydrogel injections, offering hope for future fracture prevention therapies.

Researchers at Mass General Brigham have developed a new hydrogel that continuously releases medication without breaking down under mechanical stress. The hydrogel showed promising results in preclinical studies, significantly reducing cartilage damage and improving joint lubrication.

Researchers have developed a semaglutide hydrogel that could reduce diabetes shots to once a month, improving drug adherence and quality of life. The hydrogel's slow release of semaglutide over one month was found to be well-tolerated in laboratory rats with no inflammatory reactions.

Researchers developed a composite hydrogel that integrates antibacterial, immunomodulatory, and regenerative functions to promote faster wound closure. The hydrogel demonstrated over 98% antibacterial efficacy and improved fibroblast and endothelial cell growth.

Researchers developed an antibiotic-free multifunctional injectable hydrogel that promotes tissue repair through synergistic antioxidant and antibacterial activity. The hydrogel shows compatibility with blood and surrounding tissues, delivering therapeutic agents in a controlled and sustained manner.

A new composite hydrogel containing Li-Ca-Si bioceramics particles and gelatin methacryloyl matrix has shown promise in treating dental pulp infections by facilitating innervation and odontogenic differentiation. The hydrogel promoted Schwann cell regeneration, cytocompatibility for dental pulp stem cells, and proliferation of DPSCs.