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Researchers used a LEGO robotics kit as a cheap, effective way to purify self-assembling DNA origami

07.19.23 | PLOS

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Gradient-mixing LEGO robots for purifying DNA origami nanostructures of multiple components by rate-zonal centrifugation
Side view of the LEGO gradient mixer during (A) its initial position and (B) its horizontal tilting phase. (1) 3D printed centrifuge-tube holder. (2) Spinning motor to rotate the tubes while in horizontal position. (3) Turning servo motor responsible for tilting the tubes horizontally. (4) Large grey gear connecting the two motors with its small gear complement. (5) The scaffold holding the structure together. (6) The LEGO controller for orchestrating the motions of the two motors. The black cab Credit: Sentosa et al., 2023, PLOS ONE, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283134

Article Title: Gradient-mixing LEGO robots for purifying DNA origami nanostructures of multiple components by rate-zonal centrifugation

Author Countries: USA

Funding: The research in Hariadi lab was supported by the National Institutes of Health Director’s New Innovator Award (1DP2AI144247), National Science Foundation SemiSynBio II (2027215), and Arizona Biomedical Research Consortium (ADHS17-00007401). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PLOS ONE

10.1371/journal.pone.0283134

Gradient-mixing LEGO robots for purifying DNA origami nanostructures of multiple components by rate-zonal centrifugation

19-Jul-2023

The authors have declared that no competing interests exist.

Keywords

Dna Origami Genetic Analysis Health and Medicine Nanostructures Robots

Article Information

Journal
PLOS ONE
DOI
10.1371/journal.pone.0283134
Article Publication Date
2023-07-19
Article Title
Gradient-mixing LEGO robots for purifying DNA origami nanostructures of multiple components by rate-zonal centrifugation
COI Statement
The authors have declared that no competing interests exist.

Contact Information

Hanna Abdallah
PLOS
onepress@plos.org

How to Cite This Article

APA:
PLOS. (2023, July 19). Researchers used a LEGO robotics kit as a cheap, effective way to purify self-assembling DNA origami. Brightsurf News. https://www.brightsurf.com/news/8Y452JKL/researchers-used-a-lego-robotics-kit-as-a-cheap-effective-way-to-purify-self-assembling-dna-origami.html
MLA:
"Researchers used a LEGO robotics kit as a cheap, effective way to purify self-assembling DNA origami." Brightsurf News, Jul. 19 2023, https://www.brightsurf.com/news/8Y452JKL/researchers-used-a-lego-robotics-kit-as-a-cheap-effective-way-to-purify-self-assembling-dna-origami.html.