Articles tagged with Dna Origami
Researchers at the Wyss Institute developed DoriVac, a DNA nanotechnology-enabled vaccine platform that induces broad immunity against infectious viruses, including SARS-CoV-2, HIV, and Ebola. The platform produces potent antigen-specific immune responses and is more stable and easier to manufacture than traditional vaccine platforms.
Researchers develop a novel DNA origami-based method to synthesize stable, monolithic amorphous silver nanostructures. The technique introduces geometric frustration that suppresses crystallization in metallic silver, resulting in high-stability and disordered atomic arrangements.
New research reveals that DNA's physical property of supercoiling is crucial for cells to respond to oestrogens. The study found that enzymes called topoisomerases regulate DNA coiling and activate target genes.
Researchers developed DNA origami structures that selectively deliver fluorescent imaging agents to pancreatic cancer cells, enabling more accurate cancer imaging and selective chemotherapy delivery. The study also explored the use of origami-folded DNA molecules loaded with chemotherapy drugs for targeted delivery to cancer cells.
Researchers at Caltech developed a DNA origami-based approach to create reusable, multifunctional biosensors for quickly detecting proteins in bodily fluids. The system uses a lilypad-like structure with short DNA strands to bind to molecules of interest, allowing for the detection of larger molecules such as large proteins.
Scientists at the University of Sydney create programmable nanostructures using DNA origami, enabling rapid prototyping of diverse configurations. These custom-designed nanostructures have potential applications in targeted drug delivery, responsive materials, and energy-efficient optical signal processing.
LMU researchers have developed a general, modular strategy for designing sensors that can be easily adapted to various target molecules and concentration ranges. The sensor uses a DNA origami scaffold, which consists of two arms connected by a molecular hinge, allowing for significant acceleration in diagnostic tool development.
Researchers have developed a DNA origami-based sensor that can detect lipid vesicles and deliver molecular cargo with precision. The system uses single-molecule Fluorescence Resonance Energy Transfer (smFRET) to measure the distance between fluorescent molecules.
Researchers at Seoul National University have developed a technology to quickly predict the mechanochemical shape changes of DNA origami structures based on the concentration of binding molecules. This methodology enables the design of tunable DNA origami structures that can change shape as needed, contributing to advancements in DNA n...
Researchers at Karolinska Institutet developed nanorobots that target and kill cancer cells using a 'kill switch' activated in low pH environments. The study achieved a 70% reduction in tumour growth in mice, paving the way for further investigation into its potential as a cancer treatment.
Scientists have developed a new approach for manufacturing semiconductors for visible light using DNA origami. The method uses a diamond lattice structure with periodicity of hundreds of nanometers, allowing for efficient solar cells and innovative optical waveguides.
A new DNA origami platform, DoriVac, enables precise spacing of adjuvant molecules and a variety of antigens to enhance anti-tumor responses. The vaccine demonstrated enhanced efficacy in controlling tumor growth and prolonging survival in mice, synergizing with immune checkpoint inhibitors.
Researchers have developed a working nanoscale electromotor powered by hydrodynamic flow through a nanopore. This innovation uses DNA origami to create a turbine with precise control over rotational speed and direction. The tiny motor has potential applications in molecular factories, medical probes, and soft propulsion systems.
Researchers at Karolinska Institutet used DNA origami to activate the Notch receptor in a new way, revealing it can be activated 'on demand' with the help of a protein called Jag1. The study opens new avenues for understanding the Notch signalling pathway and its role in serious diseases like cancer and Alagille Syndrome.
A Kyoto University team reveals the Dumpy protein as the key factor in controlling 3D tissue structures through external cues. This finding challenges traditional understanding of morphogenesis and opens up new avenues for manufacturing controllable 3D tissue folding with coordinated cell behaviors.
Researchers developed a cost-effective method using LEGO robots to purify complex DNA structures. The technique, called rate-zonal centrifugation, utilizes the LEGO kit's gradient-mixing capabilities to separate and isolate individual components of the nanostructures.
Scientists have developed a way to program virus particles' size and shape using DNA origami nanostructures, potentially advancing vaccine development and drug delivery. The approach uses electrostatic interactions between DNA nanostructures and capsid proteins to create user-defined assemblies.
Researchers from Karolinska Institutet and the Max Planck Institute have identified a new mechanism for DNA folding, revealing how the Smc5/6 complex regulates chromosomal organization. This discovery provides new insights into normal development and disease prevention.
A new software program developed by Duke Ph.D. student Dan Fu lets users create 3D structures made of DNA, including tiny vases, bowls, and hollow spheres. The software relies on a way to build with DNA described in 2011 by Hao Yan, which works by coiling a long DNA double helix into concentric rings to form the contours of the object.
Researchers at Aarhus University use RNA origami sponges and CRISPR technology to regulate protein production levels and gene expression in bacteria and yeast. This approach generates stable, interactive molecules for synthetic biology-based regulation, enabling unique applications in industrial, diagnostic, and therapeutic fields.
Researchers from TU Delft constructed the smallest flow-driven motors in the world using DNA, converting energy into mechanical work. The achievement opens new perspectives for engineering active robotics at the nanoscale.
Scientists have developed a DNA nano-robot that can apply forces with unprecedented accuracy, enabling closer study of mechanical forces at microscopic levels. The robot is designed to target specific mechanoreceptors, allowing researchers to activate them and study key signaling pathways involved in biological processes.
Researchers created a synthetic rotary motor using DNA origami, allowing for targeted movement and mechanical work. The nanomotors can be controlled to rotate in one direction and achieve unprecedented mechanical capabilities.
A new study from Ohio State University found that DNA nanotechnology is safe for medical use in mice, with a dose-dependent immune response. The research suggests that different shapes of nanostructures may be more conducive to different therapeutic applications.
Researchers at Karolinska Institutet have successfully repurposed a cancer drug to target neuroinflammatory diseases like multiple sclerosis. A novel drug carrier was developed to deliver the treatment specifically to microglia, reducing inflammation and disease progression.
Researchers at Arizona State University have designed and constructed artificial membrane channels using DNA, allowing selective transport of ions, proteins, and cargo. The channels can be opened and closed with a lock and key mechanism, enabling diverse scientific domains such as biosensing and drug delivery applications.
Researchers have clarified the mechanism behind activating genes in drosophila fly sex cells, which may hold clues to understanding diseases. The study's findings suggest that DNA packaging plays a crucial role in regulating gene expression, with abnormal packaging potentially leading to misregulation and disease.
Researchers create system to sense unusual DNA folds using chemical receptors, which could silence genes linked to cancer or promote tumor growth. The technology has potential applications in disease research and gene regulation.
Researchers at Harvard's Wyss Institute develop programmable DNA self-assembly strategy for ultrasensitive diagnostic biomarker detection and scalable fabrication of micrometer-sized structures. The 'crisscross polymerization' approach enables robust nucleation control and growth to large sizes.
A team of researchers from Aalto University and other institutions have developed a method to monitor the digestion of DNA nanostructures by endonucleases in real time. This study provides insights into tunable drug delivery and new design paradigms for DNA-based drug-carriers, with potential applications in cancer treatment.
Researchers used DNA origami to analyze ultra-fast movements of CRISPR enzymes, enabling them to understand how they recognize target sequences. This technique will help optimize CRISPR for fewer off-target matches and improve gene editing processes.
Researchers develop technique to precisely place and orient DNA-based molecular devices on chip surfaces. The method enables thousands of molecules to be reliably oriented, opening up new possibilities for applications like DNA sequencing and protein measurement.
Researchers have successfully fabricated superconducting nanowires using DNA origami, allowing for precise addressability and potential applications in nanoelectronics and novel devices. The technique reduces resistance by 90% at low temperatures, enabling the creation of 3D superconducting architectures.
DNA origami is a technique that folds long DNA strands to create mini 3D structures for biosensors and drug delivery. A new guide from NIST provides a comprehensive resource for researchers to design efficient nanostructures using state-of-the-art tools.
Scientists have developed a platform using DNA self-assembly to create 3D nanoscale architectures that can conduct electricity without resistance. These structures can be used in signal amplifiers, ultrasensitive magnetic field sensors, and other quantum devices.
Klimov is developing a computational platform to design antibody-antigen interfaces based on DNA origami. The goal is to predict high-affinity peptide sequences that bind to tetanus toxin, targeting structured or unstructured antigen regions.
The NIH has awarded a 4D Nucleome grant to Gladstone researchers Benoit Bruneau and Katie Pollard to investigate DNA folding in the developing heart. They aim to identify genetic causes of congenital heart disease, which affects one in 100 live births worldwide.
Scientists have developed a method to create high-resolution maps of contact points between replicated chromosomes, providing insights into the molecular machinery regulating DNA conformation and repair. This breakthrough could shed light on the mechanics underlying genome transport during cell division.
Researchers at Arizona State University have developed a new type of meta-DNA structure that can be used to engineer sophisticated nanoscale structures and devices. The meta-DNA self-assembly concept has opened up new possibilities for optoelectronics, including information storage and encryption, as well as synthetic biology.
Researchers at the University of Leeds have developed a new system to detect diseases, including coronavirus and cystic fibrosis, by examining individual molecules in blood. The method can compile a detectable signal from just a few biomarkers in just a few minutes, potentially speeding up testing and providing accurate results.
Scientists at NIST have found a way to significantly enhance the accuracy of key information on how heat affects the stability of folded DNA structures. The novel mathematical algorithm automatically accounts for unknown effects, allowing scientists to design durable and complex structures made from DNA.
Researchers used DNA origami to create virus-like particles coated with HIV proteins, eliciting a strong immune response from human B cells. The study found that the optimal spacing between antigens is wider than previously thought, contradicting common assumptions.
Researchers develop peptoid-coated DNA origami that maintains structural integrity and functionality in different physiological environments, enabling potential use in delivering anti-cancer drugs and proteins. The method involves designing peptoids to stabilize DNA origami, with the brush-type architecture achieving optimal protection.
Researchers at Delft University of Technology have discovered a new loop structure in DNA, called the 'Z loop', which differs from traditional single loops and occurs more frequently. This discovery sheds light on how condensin proteins fold DNA into a zigzag structure through complex interactions.
Researchers developed a rod-shaped DNA motor that rolls at speeds up to 100 nanometers per minute, breaking previous records. The motor uses RNA fuel and can travel the length of a human stem cell in two or three hours.
Researchers found that jumping genes, also known as transposable elements, play a crucial role in stabilizing the 3D folding patterns of DNA molecules. This discovery contradicts the long-held assumption that the precise order of letters in the DNA sequence dictates the broader structure of the DNA molecule.
Scientists successfully created a large synthetic nanopore made from DNA with a functional gating system for sensing and bio-sensing applications. The pore can translocate large protein-sized macromolecules between compartments separated by a lipid bilayer, enabling label-free real-time biosensing of trigger molecules.
Researchers at Rensselaer Polytechnic Institute develop a DNA star trap that captures and detects Dengue virus in the bloodstream, outperforming existing clinical tests by over 100 fold. The non-toxic, biodegradable test could be adapted to kill viruses as well.
Researchers optimized DNA-PAINT for faster image acquisition using orthogonal DNA sequences, achieving sub-10nm spatial resolution and multiplexing capabilities. This improvement allows for biomedically relevant high-throughput studies, such as diagnostic applications.
Researchers have developed DNA-based microcapsules that can act as ion channels, enabling the creation of artificial cells and molecular robots. This breakthrough could accelerate advances in nanotechnology and biomedical applications.
The team, led by Xiaowei Zhuang, captured the first recorded rotational steps of a molecular motor as it moved from one DNA base pair to another. They used DNA origami to build molecule-sized propellers that allowed them to visualize the motor's movement.
Researchers at Hokkaido University successfully assembled a larger biomolecular motor system using DNA origami, overcoming previous scalability challenges. The system, combining fibrous microtubules and motor protein kinesins, exhibits dynamic contraction when energized by ATP.
Researchers studied over 8,000 genes and proteins in acute lymphoblastic leukaemia (ALL) patients, finding abnormal DNA folding and gene activity. This discovery could improve understanding of hyperdiploid childhood leukaemia and develop more effective treatments.
Researchers developed a computer program that translates free-form drawings into DNA structures, enabling users to create complex nanostructures for various applications. The 'PERDIX' program uses a mathematical approach to automate the design process, making it accessible to anyone with basic drawing skills.
New research allows for fully automated design of DNA staple sequences, enabling the creation of complex nanostructures with ease. This breakthrough advances the field of DNA origami, opening up new possibilities for applications in material science and medicine.
Caltech scientists develop dynamic DNA nanostructures, enabling the creation of a microscopic tic-tac-toe game board with reconfigurable parts. The technology combines self-assembling tiles and strand displacement to allow for molecular self-reconfiguration, paving the way for more sophisticated nanomachines.
Researchers at Arizona State University have developed a method to create complex knot-like nanostructures in single-stranded DNA, with crossing numbers ranging from 9 to 57. This breakthrough enables the design of molecular structures with specific functions and unprecedented complexity.
Nicholas Stephanopoulos and Rizal Hariadi, researchers at the Biodesign Center, received a $2.3 million grant to explore peptide DNA nanotechnology and its applications in biomedicine. The award supports exceptionally creative early career investigators with high-impact projects.
Scientists have created a nanosized sensing probe for RNA molecules using DNA origami and gold nanorods. The probe can detect concentrations as low as 100 picomolar of the target RNA, making it a promising diagnostic tool for viral infections.
Scientists at the University of Pennsylvania discovered a common thread linking nearly all TNR expansion diseases: misfolded 3D genome patterns. Nearly all unstable repeats are located at genome folding boundaries, suggesting new research questions for diagnosis or treatment.