Articles tagged with Dna Origami
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Ohio State University have made a significant breakthrough in controlling DNA-based robots, reducing response time from several minutes to less than a second. This achievement represents the first direct real-time control of DNA-based molecular machines.
Researchers developed a gentle buffer exchange method to remove free ions, enabling DNA origami stability at low-magnesium levels. This breakthrough paves the way for various biomedical uses, including drug and enzyme delivery.
Researchers use DNA-PAINT technique to visualize individual strands in DNA origami nanostructures, revealing the robustness of assembly and incorporation efficiency of staple strands. The results show that variations in structure formation speed have little influence on overall quality, but some sites remain unoccupied.
Berkeley Lab researchers generate 3-D images of 129 DNA structures, revealing the dynamics and flexibility of DNA origami particles. The method used provides a new strategy for improving control over large DNA scaffolds by redesigning DNA sequences near joints to stiffen the structure.
Aalto University researchers have developed a new method called DALI (DNA-assisted lithography) to fabricate precise metallic nanostructures with designed plasmonic properties. The technique uses self-assembled DNA origami shapes as 'stencils' to create millions of fully metallic nanostructures. These structures have intriguing optical...
Scientists develop single-stranded DNA origami, a breakthrough in nanotechnology that can create complex structures without knots. The technology has potential applications in medicine, including delivering drugs inside cells.
Researchers have developed a novel approach to design complex single-stranded DNA and RNA origami that can autonomously fold into diverse, stable structures. This enables the production of large nanostructures at low cost and high purity, opening opportunities for applications in drug delivery and nanofabrication.
Researchers at Caltech developed a method to assemble large DNA structures with customizable patterns, creating a 'canvas' that can display any image. They used fractal assembly to recreate the world's smallest Mona Lisa using DNA origami.
Researchers at the University of Freiburg discover that DNA folding reorganization is a key switch for defining cell types during cardiomyocyte differentiation. The study reveals that spatial genome organization determines cellular identity and provides insights into future reprogramming strategies.
Researchers develop a method for assembling colloidal clusters using origami DNA, allowing precise control over particle orientation and properties. The technique enables the creation of clusters with specified chirality, which could lead to improved understanding and utilization of particles with unique optical or magnetic properties.
A study published in Science reveals that archaeal DNA folding is identical to the process found in more complex organisms, suggesting an early prototype for the eukaryotic nucleosome. This discovery sheds light on the evolutionary origins of genome folding and raises questions about the common ancestor of life.
Studies of microbe DNA structure reveal surprising similarities to human DNA folding, suggesting an early common ancestor. The discovery hints at the evolutionary origins of genome folding in eukaryotes.
Researchers at Kent State University created a nano cage to study G-quadruplex formation, a genetic factor associated with cancer cell growth. The discovery may lead to new understanding of how cancer develops and provide potential treatments.
Scientists at Caltech have developed a method to combine deterministic and random processes for creating complex nanostructures out of DNA. By controlling the design of individual tiles and their interactions, they can produce emergent features with tunable statistical properties, including loop, maze, and tree structures.
Researchers at Caltech use DNA origami to precisely place glowing molecules within microscopic light resonators, creating a microscopic reproductions of Vincent van Gogh's The Starry Night. By mapping out a checkerboard pattern of hot and cold spots, they can position fluorescent molecules to make lamps of varying intensity.
Researchers are using DNA origami to create large, two-dimensional honeycombs and tubes with precise structures. They aim to develop new medicines by exposing the immune system to DNA origami scaffolds holding virus pieces, and explore protein arrangements for sophisticated medicines and electronic devices.
Researchers have designed DNA frames to connect nanoparticles into precisely structured lattices, enabling the creation of nanomaterials with tailored properties. The team's method uses DNA origami to self-assemble particles into desired shapes, reducing dependence on particle modification.
Researchers at MIT have developed an algorithm that can build complex DNA nanoparticles automatically, allowing for a broader range of applications in fields such as vaccine development and gene editing. The algorithm, known as DAEDALUS, can build any type of 3D shape with a closed surface, including shapes with holes.
A new method for designing geometric forms built from DNA has been developed, allowing for the creation of tiny structures in 2 and 3 dimensions. The technique, known as DNA origami, relies on a top-down strategy and can produce virtually any polyhedral shape.
Researchers are exploring DNA origami to create nanoscale structures for electronics, potentially leading to smaller, faster, and cheaper computer chips. The technique involves forming specific shapes in DNA to create three-dimensional structures that can be used as a scaffold for other materials.
Scientists at TUM create two new nanoscale machines with moving parts using DNA origami techniques, pushing the limits of programmable, self-assembling construction material. The rotor mechanism can swing freely or dwell in specified positions, while a hinged machine demonstrates precise placement of individual molecules.
Researchers at UC Davis have demonstrated that DNA can be modulated to act as an electromechanical switch, enabling the design of unique nanodevices. The discovery could lead to new paradigms for computing and improve energy efficiency in electronic devices.
Scientists at Kyoto University developed an approach to assemble DNA origami units into larger structures by using a double layer of lipids. This method allows for more freedom of movement and interaction between origami structures, enabling them to form nanomachines such as nanomotors for targeted drug delivery
Researchers have created complex nanoforms displaying arbitrary wireframe architectures using novel organizational principles. These structures include symmetrical lattice arrays, quasicrystalline patterns, and 3D objects with precise control over branching and curvature.
Researchers created bundles of double-helix molecules and used them to form a rigid framework, then added complementary strands to glue nanoparticles in place. This method produced predictable clusters and arrays with tailored structures and functions.
Researchers at TUM have developed a new approach to joining modular 3D building units using shape complementarity, enabling practical nanomachines with moving parts. This breakthrough offers a toolkit for easy programming of self-assembly, paving the way for applications in DNA origami.
Researchers at Ohio State University have designed DNA origami machines that can perform tasks repeatedly, using natural and synthetic DNA to mimic macroscopic machine design principles. The machines can detect signals, process information, and respond accordingly, opening the door for complex nano-robots in biomedical applications.
The researchers created a new standard for large-scale DNA origami structures, enabling applications in biomedical research and nanoelectronics. The breakthrough involved developing a custom scaffold strand and cost-effective method for synthesizing staple strands.
Researchers create RNA origami structures by encoding folding recipes into single-strand RNAs, allowing for self-folding and organization of molecules on the nanoscale. The method has potential applications in cellular engineering, biochemical factories, and molecular scaffolds.
Researchers have developed a method using DNA origami to turn one-dimensional nano materials into two dimensions, enabling the creation of any number of shapes. The breakthrough offers potential to enhance fiber optics and electronic devices by reducing size and increasing speed.
Researchers at Harvard's Wyss Institute created the largest standalone 3-D DNA structures using self-assembling DNA cages. The cages can be modified with chemical hooks to enclose contents, such as drugs or proteins, for potential medical applications.
Scientists have developed a new DNA-based, super-resolution microscopy method called Exchange-PAINT that can visualize up to dozens of different biomolecules at once in a single cell. This allows for a more accurate understanding of complex cellular functions and potential new ways to diagnose disease.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf develop a simpler method to align DNA nanostructures on surfaces, enabling the creation of self-aligned nanotubes with potential applications in electronic circuits. The technique uses electrostatic interactions and natural pattern formation to achieve alignment with high yield.
Scientists have made significant breakthroughs in DNA nanotechnology by removing obstacles to design processes. They demonstrated the first validation of subnanometer-scale positional control and discovered a method for rapid folding and high-yield production of complex DNA-based objects, similar to protein folding.
Scientists at Karolinska Institutet developed a new technique using under-twisted DNA origami to deliver cancer drugs, such as doxorubicin, directly to tumor cells while minimizing harm to surrounding healthy tissue. This approach allows for slower release of the drug, enabling more effective treatment at lower concentrations.
Researchers at TUM developed DNA origami 'gatekeepers' that can filter biomolecules by size, allowing selective detection of specific target molecules. The device combines solid-state nanopores with custom-designed DNA structures for enhanced single-molecule sensing capabilities.
Researchers at Ludwig Institute for Cancer Research used powerful sequencing technology to investigate the three-dimensional structure of DNA folds in the nucleus. They found that DNA folds into local domains called topological domains, which are essential for gene regulation.
Researchers have successfully built nano spiral staircases with tailored optical material from DNA, modifying light in specific ways. The findings confirm predictions and show promise for developing novel optical lens systems with negative refractive index.
NIST researchers studied the self-assembly of quantum dots using DNA origami, determining critical factors and error rates. They found that simple structures take up to 24 hours to assemble with an error rate of about 5 percent.
Researchers at Kyoto University and the University of Oxford have successfully constructed a DNA motor capable of navigating a programmable network of tracks with multiple switches. The breakthrough uses DNA origami technology, allowing for autonomous nanoscale devices to produce predictable outputs based on different starting conditions.
Researchers at EPFL and University of Geneva uncover a genetic mechanism that modulates gene activity through seven enhancers, leading to diversity in finger shapes. This discovery could help understand hereditary malformations and evolutionary variations in the animal kingdom.
Duke University researchers have developed a reusable DNA chip that can synthesize multiple batches of DNA building blocks and fold them into unique nanostructures. They successfully reused the chip tens of times without significant degradation, paving the way for applications in synthetic biology, drug delivery, and nanotechnology.
A team at MIT led by Mark Bathe has developed software to predict the three-dimensional shape of complex DNA structures, making it easier to create nanoassembly technology. This advancement enables biologists, chemists, and materials scientists to design and build intricate shapes using DNA without extensive expertise in DNA origami.
Researchers at Arizona State University have developed a method to construct arbitrary, two and three-dimensional shapes using DNA origami. The new technique allows for the creation of complex curvature in 3D nanostructures, enabling potential applications in ultra-tiny computing components and nanomedical devices.
Researchers at Arizona State University created nanoscale DNA Möbius strips, measuring 50 nanometers across, using DNA origami and Kirigami techniques. The unique structures have potential applications in biology, chemistry, and electronics.
Researchers at NYU and Nanjing University have created a DNA-based assembly line that can efficiently produce novel materials on the nanoscale. The system uses three components: DNA origami, programmable cargo-donating devices, and a DNA walker, allowing for precise control over material creation.
Researchers have created autonomous molecular 'robots' made of DNA that can be programmed to follow a track, start, move, turn and stop. The development could lead to molecular systems used in medical therapeutic devices and reconfigurable robots.
Researchers have developed a method to deterministically position silver nanoparticles onto self-assembling DNA scaffolds, paving the way for new biomedical applications and precise sensing operations. The study demonstrates the viability of using silver instead of gold nanoparticles in DNA-based architectures.
Researchers have made a breakthrough in engineering nanoscale materials, enabling the creation of large-scale arrays of individual structures with precise locations. This discovery could lead to advancements in sensing, transistors, and other applications.
Researchers used DNA origami to create molecular breadboards, solving the challenge of organizing carbon nanotubes into nanoscale electronic circuits. The innovative technique exploits DNA's sequence-recognition properties and stickiness to 'stick' carbon nanotubes onto its surface.
Researchers have created a new technology using DNA origami that can form tiny letters with multiple branching points, addressing the need for narrow features in nanoelectronics. The breakthrough could lead to the development of nanoscale devices with unprecedented capabilities.
Researchers from Brigham Young University have successfully created a customized DNA origami technique to write the letters B-Y-U on an extremely small scale. This breakthrough enables the design of nanoscale shapes for electrical circuitry and the creation of inexpensive computer chips.
Scientists at Caltech and IBM's Almaden Research Center have developed a technique to orient and position self-assembled DNA shapes on surfaces compatible with semiconductor manufacturing equipment. This allows for the precise assembly of computer-chip components, enabling smaller, faster, and more energy-efficient chips.
Scientists at TUM and Harvard University have successfully programmed DNA to assemble into complex twisted and curved nanoscale shapes. The researchers report achieving precise control over the shape's curvature and twist, with potential applications in building miniaturized devices for biomedical applications.
Researchers at Dana-Farber Cancer Institute have developed a method to fold sheets of DNA into multilayered objects with precise control. These structures can be used as custom-made biomedical nanodevices, such as smart delivery vehicles that target specific molecular targets.
Researchers at Caltech have successfully created a system using DNA origami seeds that can direct the self-assembled growth of DNA tiles into precise forms. This breakthrough demonstrates unprecedented control over information-directed molecular self-assembly, paving the way for future applications in technology and materials science.
Researchers at Arizona State University develop a gene detection platform using self-assembled DNA nanostructures, enabling label-free detection of RNA genes in single cells. The technology has potential applications for disease diagnosis and could revolutionize the way gene expression is analyzed.
Paul Rothemund's 'scaffolded DNA origami' technique allows for 10-fold more complex shapes, including snowflakes and a map of the Americas, with minimal design expertise required. This approach breaks traditional rules for nanoscale fabrication with DNA, paving the way for potential applications in electronics and self-assembled devices.
Researchers control RNA structure by attaching DNA strands, allowing precise folding and manipulation of RNAs. The technique also enables reversible or irreversible changes to molecular shapes, offering programmability and potential applications in biological and non-biological systems.
Researchers at Scripps Research have created a single, clonable strand of DNA that folds into an octahedron with potential applications in biomedical science, electronics, and computing. The structure can be amplified and replicated using standard molecular biology tools.