Articles tagged with Dna Origami
Researchers at Arizona State University have developed a method to create complex knot-like nanostructures in single-stranded DNA, with crossing numbers ranging from 9 to 57. This breakthrough enables the design of molecular structures with specific functions and unprecedented complexity.
Nicholas Stephanopoulos and Rizal Hariadi, researchers at the Biodesign Center, received a $2.3 million grant to explore peptide DNA nanotechnology and its applications in biomedicine. The award supports exceptionally creative early career investigators with high-impact projects.
Scientists have created a nanosized sensing probe for RNA molecules using DNA origami and gold nanorods. The probe can detect concentrations as low as 100 picomolar of the target RNA, making it a promising diagnostic tool for viral infections.
Scientists at the University of Pennsylvania discovered a common thread linking nearly all TNR expansion diseases: misfolded 3D genome patterns. Nearly all unstable repeats are located at genome folding boundaries, suggesting new research questions for diagnosis or treatment.
Arizona State University scientists create diatom-like nanostructures using DNA origami, improving elasticity and durability. The method has far-reaching applications in optical systems, semiconductor nanolithography, and medical applications.
Researchers at Ohio State University have made a significant breakthrough in controlling DNA-based robots, reducing response time from several minutes to less than a second. This achievement represents the first direct real-time control of DNA-based molecular machines.
Researchers developed a gentle buffer exchange method to remove free ions, enabling DNA origami stability at low-magnesium levels. This breakthrough paves the way for various biomedical uses, including drug and enzyme delivery.
Researchers use DNA-PAINT technique to visualize individual strands in DNA origami nanostructures, revealing the robustness of assembly and incorporation efficiency of staple strands. The results show that variations in structure formation speed have little influence on overall quality, but some sites remain unoccupied.
Berkeley Lab researchers generate 3-D images of 129 DNA structures, revealing the dynamics and flexibility of DNA origami particles. The method used provides a new strategy for improving control over large DNA scaffolds by redesigning DNA sequences near joints to stiffen the structure.
Aalto University researchers have developed a new method called DALI (DNA-assisted lithography) to fabricate precise metallic nanostructures with designed plasmonic properties. The technique uses self-assembled DNA origami shapes as 'stencils' to create millions of fully metallic nanostructures. These structures have intriguing optical...
Scientists develop single-stranded DNA origami, a breakthrough in nanotechnology that can create complex structures without knots. The technology has potential applications in medicine, including delivering drugs inside cells.
Researchers have developed a novel approach to design complex single-stranded DNA and RNA origami that can autonomously fold into diverse, stable structures. This enables the production of large nanostructures at low cost and high purity, opening opportunities for applications in drug delivery and nanofabrication.
Researchers at Caltech developed a method to assemble large DNA structures with customizable patterns, creating a 'canvas' that can display any image. They used fractal assembly to recreate the world's smallest Mona Lisa using DNA origami.
Researchers at the University of Freiburg discover that DNA folding reorganization is a key switch for defining cell types during cardiomyocyte differentiation. The study reveals that spatial genome organization determines cellular identity and provides insights into future reprogramming strategies.
Researchers develop a method for assembling colloidal clusters using origami DNA, allowing precise control over particle orientation and properties. The technique enables the creation of clusters with specified chirality, which could lead to improved understanding and utilization of particles with unique optical or magnetic properties.
Studies of microbe DNA structure reveal surprising similarities to human DNA folding, suggesting an early common ancestor. The discovery hints at the evolutionary origins of genome folding in eukaryotes.
A study published in Science reveals that archaeal DNA folding is identical to the process found in more complex organisms, suggesting an early prototype for the eukaryotic nucleosome. This discovery sheds light on the evolutionary origins of genome folding and raises questions about the common ancestor of life.
Researchers at Kent State University created a nano cage to study G-quadruplex formation, a genetic factor associated with cancer cell growth. The discovery may lead to new understanding of how cancer develops and provide potential treatments.
Scientists at Caltech have developed a method to combine deterministic and random processes for creating complex nanostructures out of DNA. By controlling the design of individual tiles and their interactions, they can produce emergent features with tunable statistical properties, including loop, maze, and tree structures.
Researchers at Caltech use DNA origami to precisely place glowing molecules within microscopic light resonators, creating a microscopic reproductions of Vincent van Gogh's The Starry Night. By mapping out a checkerboard pattern of hot and cold spots, they can position fluorescent molecules to make lamps of varying intensity.
Researchers are using DNA origami to create large, two-dimensional honeycombs and tubes with precise structures. They aim to develop new medicines by exposing the immune system to DNA origami scaffolds holding virus pieces, and explore protein arrangements for sophisticated medicines and electronic devices.
Researchers have designed DNA frames to connect nanoparticles into precisely structured lattices, enabling the creation of nanomaterials with tailored properties. The team's method uses DNA origami to self-assemble particles into desired shapes, reducing dependence on particle modification.
Researchers at MIT have developed an algorithm that can build complex DNA nanoparticles automatically, allowing for a broader range of applications in fields such as vaccine development and gene editing. The algorithm, known as DAEDALUS, can build any type of 3D shape with a closed surface, including shapes with holes.
A new method for designing geometric forms built from DNA has been developed, allowing for the creation of tiny structures in 2 and 3 dimensions. The technique, known as DNA origami, relies on a top-down strategy and can produce virtually any polyhedral shape.
Researchers are exploring DNA origami to create nanoscale structures for electronics, potentially leading to smaller, faster, and cheaper computer chips. The technique involves forming specific shapes in DNA to create three-dimensional structures that can be used as a scaffold for other materials.
Scientists at TUM create two new nanoscale machines with moving parts using DNA origami techniques, pushing the limits of programmable, self-assembling construction material. The rotor mechanism can swing freely or dwell in specified positions, while a hinged machine demonstrates precise placement of individual molecules.
Researchers at UC Davis have demonstrated that DNA can be modulated to act as an electromechanical switch, enabling the design of unique nanodevices. The discovery could lead to new paradigms for computing and improve energy efficiency in electronic devices.
Scientists at Kyoto University developed an approach to assemble DNA origami units into larger structures by using a double layer of lipids. This method allows for more freedom of movement and interaction between origami structures, enabling them to form nanomachines such as nanomotors for targeted drug delivery
Researchers have created complex nanoforms displaying arbitrary wireframe architectures using novel organizational principles. These structures include symmetrical lattice arrays, quasicrystalline patterns, and 3D objects with precise control over branching and curvature.
Researchers created bundles of double-helix molecules and used them to form a rigid framework, then added complementary strands to glue nanoparticles in place. This method produced predictable clusters and arrays with tailored structures and functions.
Researchers at TUM have developed a new approach to joining modular 3D building units using shape complementarity, enabling practical nanomachines with moving parts. This breakthrough offers a toolkit for easy programming of self-assembly, paving the way for applications in DNA origami.
Researchers at Ohio State University have designed DNA origami machines that can perform tasks repeatedly, using natural and synthetic DNA to mimic macroscopic machine design principles. The machines can detect signals, process information, and respond accordingly, opening the door for complex nano-robots in biomedical applications.
The researchers created a new standard for large-scale DNA origami structures, enabling applications in biomedical research and nanoelectronics. The breakthrough involved developing a custom scaffold strand and cost-effective method for synthesizing staple strands.
Researchers create RNA origami structures by encoding folding recipes into single-strand RNAs, allowing for self-folding and organization of molecules on the nanoscale. The method has potential applications in cellular engineering, biochemical factories, and molecular scaffolds.
Researchers have developed a method using DNA origami to turn one-dimensional nano materials into two dimensions, enabling the creation of any number of shapes. The breakthrough offers potential to enhance fiber optics and electronic devices by reducing size and increasing speed.
Researchers at Harvard's Wyss Institute created the largest standalone 3-D DNA structures using self-assembling DNA cages. The cages can be modified with chemical hooks to enclose contents, such as drugs or proteins, for potential medical applications.
Scientists have developed a new DNA-based, super-resolution microscopy method called Exchange-PAINT that can visualize up to dozens of different biomolecules at once in a single cell. This allows for a more accurate understanding of complex cellular functions and potential new ways to diagnose disease.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf develop a simpler method to align DNA nanostructures on surfaces, enabling the creation of self-aligned nanotubes with potential applications in electronic circuits. The technique uses electrostatic interactions and natural pattern formation to achieve alignment with high yield.
Scientists have made significant breakthroughs in DNA nanotechnology by removing obstacles to design processes. They demonstrated the first validation of subnanometer-scale positional control and discovered a method for rapid folding and high-yield production of complex DNA-based objects, similar to protein folding.
Scientists at Karolinska Institutet developed a new technique using under-twisted DNA origami to deliver cancer drugs, such as doxorubicin, directly to tumor cells while minimizing harm to surrounding healthy tissue. This approach allows for slower release of the drug, enabling more effective treatment at lower concentrations.
Researchers at TUM developed DNA origami 'gatekeepers' that can filter biomolecules by size, allowing selective detection of specific target molecules. The device combines solid-state nanopores with custom-designed DNA structures for enhanced single-molecule sensing capabilities.
Researchers at Ludwig Institute for Cancer Research used powerful sequencing technology to investigate the three-dimensional structure of DNA folds in the nucleus. They found that DNA folds into local domains called topological domains, which are essential for gene regulation.
Researchers have successfully built nano spiral staircases with tailored optical material from DNA, modifying light in specific ways. The findings confirm predictions and show promise for developing novel optical lens systems with negative refractive index.
NIST researchers studied the self-assembly of quantum dots using DNA origami, determining critical factors and error rates. They found that simple structures take up to 24 hours to assemble with an error rate of about 5 percent.
Researchers at Kyoto University and the University of Oxford have successfully constructed a DNA motor capable of navigating a programmable network of tracks with multiple switches. The breakthrough uses DNA origami technology, allowing for autonomous nanoscale devices to produce predictable outputs based on different starting conditions.
Researchers at EPFL and University of Geneva uncover a genetic mechanism that modulates gene activity through seven enhancers, leading to diversity in finger shapes. This discovery could help understand hereditary malformations and evolutionary variations in the animal kingdom.
Duke University researchers have developed a reusable DNA chip that can synthesize multiple batches of DNA building blocks and fold them into unique nanostructures. They successfully reused the chip tens of times without significant degradation, paving the way for applications in synthetic biology, drug delivery, and nanotechnology.
A team at MIT led by Mark Bathe has developed software to predict the three-dimensional shape of complex DNA structures, making it easier to create nanoassembly technology. This advancement enables biologists, chemists, and materials scientists to design and build intricate shapes using DNA without extensive expertise in DNA origami.
Researchers at Arizona State University have developed a method to construct arbitrary, two and three-dimensional shapes using DNA origami. The new technique allows for the creation of complex curvature in 3D nanostructures, enabling potential applications in ultra-tiny computing components and nanomedical devices.
Researchers at Arizona State University created nanoscale DNA Möbius strips, measuring 50 nanometers across, using DNA origami and Kirigami techniques. The unique structures have potential applications in biology, chemistry, and electronics.
Researchers have created autonomous molecular 'robots' made of DNA that can be programmed to follow a track, start, move, turn and stop. The development could lead to molecular systems used in medical therapeutic devices and reconfigurable robots.
Researchers at NYU and Nanjing University have created a DNA-based assembly line that can efficiently produce novel materials on the nanoscale. The system uses three components: DNA origami, programmable cargo-donating devices, and a DNA walker, allowing for precise control over material creation.
Researchers have developed a method to deterministically position silver nanoparticles onto self-assembling DNA scaffolds, paving the way for new biomedical applications and precise sensing operations. The study demonstrates the viability of using silver instead of gold nanoparticles in DNA-based architectures.
Researchers have made a breakthrough in engineering nanoscale materials, enabling the creation of large-scale arrays of individual structures with precise locations. This discovery could lead to advancements in sensing, transistors, and other applications.
Researchers used DNA origami to create molecular breadboards, solving the challenge of organizing carbon nanotubes into nanoscale electronic circuits. The innovative technique exploits DNA's sequence-recognition properties and stickiness to 'stick' carbon nanotubes onto its surface.
Researchers have created a new technology using DNA origami that can form tiny letters with multiple branching points, addressing the need for narrow features in nanoelectronics. The breakthrough could lead to the development of nanoscale devices with unprecedented capabilities.
Researchers from Brigham Young University have successfully created a customized DNA origami technique to write the letters B-Y-U on an extremely small scale. This breakthrough enables the design of nanoscale shapes for electrical circuitry and the creation of inexpensive computer chips.
Scientists at Caltech and IBM's Almaden Research Center have developed a technique to orient and position self-assembled DNA shapes on surfaces compatible with semiconductor manufacturing equipment. This allows for the precise assembly of computer-chip components, enabling smaller, faster, and more energy-efficient chips.
Scientists at TUM and Harvard University have successfully programmed DNA to assemble into complex twisted and curved nanoscale shapes. The researchers report achieving precise control over the shape's curvature and twist, with potential applications in building miniaturized devices for biomedical applications.
Researchers at Dana-Farber Cancer Institute have developed a method to fold sheets of DNA into multilayered objects with precise control. These structures can be used as custom-made biomedical nanodevices, such as smart delivery vehicles that target specific molecular targets.