Key findings
• Quantitative parameters K trans and V e values of contrast enhanced magnetic resonance imaging (DCE-MRI) showed high diagnostic efficacy for malignant solid solitary pulmonary nodules (SSPNs).
• Quantitative DCE-MRI parameters of SSPNs correlate with some vascular architectural parameters.
• DCE-MRI provides a non-invasive, ionizing radiation-free method for the differential diagnosis of SSPNs.
What is known and what is new?
• Early diagnosis of SSPNs is critical for improving prognosis and enhancing survival.
• Microvessel density, vascular endothelial growth factor and microvascular perfusion index are histological markers reflecting tumor microangiogenesis and vascular normalization.
• DCE-MRI is now clinically used to evaluate microvascular changes in tumors of such as breast, prostate and rectal cancer.
• Our study adds conventional MRI scanning with respiratory gating as well as artifact correction to ensure image quality.
• Differential diagnosis of SSPNs at the level of the vascular microenvironment using quantitative DCE-MRI parameters is helpful.
What is the implication, and what should change now?
• Due to improvements in scanning and post-processing techniques, magnetic resonance technology has been progressively used in the differential diagnosis of lung lesions, assessment of efficacy, and prediction of prognosis.
• Evaluation of SSPNs that are difficult to identify clinically can be attempted by means of DCE-MRI examination.
Journal of Thoracic Disease
Observational study
People
Original Article
24-Jan-2025
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-24-1467/coif). The authors have no conflicts of interest to declare.