BME Frontiers (BMEF), a Science Partner Journal published by the American Association for the Advancement of Science (AAAS) in collaboration with the Suzhou Institute of Biomedical Engineering and Technology (SIBET, CAS), is pleased to announce a call for papers for its upcoming special issue: ‘Multi-Organ Interaction Systems: Biomimetics, Homeostasis, and Intelligent Monitoring.”
Multi-organ interaction systems are rapidly emerging as powerful experimental platforms for investigating inter-organ communication, systemic physiological regulation, disease mechanisms, and responses to therapeutic interventions. By integrating organoids, engineered tissues, and interconnected microphysiological modules, these systems seek to faithfully reproduce key aspects of multi-organ crosstalk under controlled conditions. This creates unprecedented opportunities for mechanistic studies, preclinical drug evaluation, and precision medicine.
Despite substantial progress in the field, significant challenges remain. Researchers still face hurdles in reconstructing complex multi-organ architectures, sustaining long-term physiological homeostasis, monitoring dynamic inter-organ responses in real time, and seamlessly connecting experimental observations with predictive computational models. Overcoming these bottlenecks requires coordinated, cross-disciplinary advances in tissue engineering, biomaterials, microfluidics, biosensing, biomedical imaging, and computational biology.
To address these critical frontiers, this special issue invites both Original Research and Review articles that focus on the biomimetic design, homeostatic regulation, multimodal monitoring, quantitative evaluation, and computational analysis of multi-organ interaction systems. Particular emphasis is placed on physiological relevance, long-term operational stability, quantitative measurement, and translational potential.
The topics specifically sought include, but are not limited to:
Biomimetic multi-organ platforms
Long-term culture and homeostasis
Mechanisms of inter-organ crosstalk
Multiscale, cross-organ blood-flow imaging and quantitative assessment
Multimodal sensing and intelligent monitoring
Computational models and AI-assisted analysis
The special issue is led by a distinguished team of Guest Editors: Ning Gu (Professor, Nanjing University), Dong Zhang (Professor, Nanjing University), Juan Tu (Professor, Nanjing University), and Jingyi Sheng (Southeast University).
The submission deadline is June 30, 2027.
For more information and to submit your manuscript, please visit the journal's official website: https://spj.science.org/journal/bmef.
About BME Frontiers
BMEF ( BME Frontiers ) is a Science Partner Journal distributed by the American Association for the Advancement of Science (AAAS) in collaboration with the Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences. BMEF is indexed in: CNKI, DOAJ, Inspec , PubMed Central, Scopus, ESCI, and Ei Compendex . In 2025, BMEF achieved Journal Impact Factor (JIF) of 9.2 and CiteScore of 12.4 , in the top quartile (Q1) of Biomedical Engineering journals.