Articles tagged with Tissue Engineering
New research reveals that asthma attacks cause overproduction of extracellular proteins and growth of blood vessels in the airways. Over time, these changes lead to constriction of breathing passages, resulting in long-term respiratory issues.
Researchers found that CAR3 coordinates bone formation and regeneration by forming a molecular complex with collagen type I alpha 1 and recruiting bone sialoprotein. The study identified CAR3 as a previously unrecognized regulator of osteoblast differentiation, highlighting its potential for treating bone disorders.
Researchers developed a topical gel formulation with 4-aminopyridine to treat burn wounds, achieving near-complete closure in 21 days. The gel delivers the drug directly to the wound site, avoiding systemic risks associated with prolonged use.
Researchers at the Hebrew University of Jerusalem have created a novel method for cultivating meat using plant-derived cellulose scaffolds. This approach significantly reduces production costs by infusing growth factors directly into the scaffold, allowing for comparable tissue development with lower factor usage.
A novel therapeutic paradigm combines electroacupuncture with regenerative tissue engineering to enhance nerve regeneration and functional recovery in spinal cord injury. The study found that electroacupuncture stimulation improved neural signal transmission, suppressed neuroinflammation, and promoted myelin regeneration.
Researchers at Cincinnati Children's Hospital Medical Center have developed a new method to produce large, functional human gut organoids with nerve cells, growing them twice as fast as previous methods. These organoids can now be used for patching damage or restoring diminished functions of the small intestine, stomach, or colon.
Researchers developed cardiac organoids to address limitations of cell-based therapies in myocardial infarction. These three-dimensional tissue constructs integrate into host tissue, improve cardiac function, and reduce scar size without arrhythmogenic effects.
Researchers at McGill University have developed a rapid way to engineer blood clots that stop severe bleeding and support tissue healing more effectively. The technique, called 'click clotting,' links red blood cell surface proteins through a chemical reaction, resulting in a biocompatible clot.
Researchers from Lund University successfully harnessed the regenerative capacity of Scandinavian flatworms to accelerate wound healing in human skin models. The study found that signalling molecules from flatworm exosomes increased skin thickness and improved wound healing rates, including accelerated blood vessel regeneration.
Researchers at University of Michigan created a stem cell model that produces a yolk-sac-like structure in a human embryo, mimicking early pregnancy loss. The model uses mechanical signals to guide development and does not require genetic manipulation.
Researchers at IBEC and EMBL develop a strategy to program tissue shape changes by controlling cell orientation. The team creates living tissues with reproducible three-dimensional structures, enabling applications in tissue engineering and biohybrid robotics.
Anand Ramamurthi, Lehigh's Peter C. Rossin Professor of Bioengineering and chair of the Department of Bioengineering, has been elected to the AIMBE College of Fellows for his groundbreaking work in regenerative technologies that can repair damaged tissues without surgery. His research aims to develop nonsurgical nanomedicines to treat ...
Oregon Health & Science University has received significant NIH funding to develop advanced microphysiologic models that mimic how cancers grow and respond to treatment within bone tissues. Two new awards focus on osteosarcoma and prostate cancer, aiming to improve understanding of disease spread and treatment responses.
Researchers found that extracellular vesicles from menstrual blood stromal cells can improve cartilage function and slow tissue degradation, even in older postmenopausal women. Biomimetic scaffolds are being developed to prolong the effects of these particles, offering a potential cell-free therapy for osteoarthritis.
A team of researchers has achieved a major milestone in developing a new treatment aimed at helping the body repair damaged joints at the source. The experimental treatments have shown promising results in animal models, restoring joint tissue to near-normal levels and significantly reducing pain markers for long periods.
The Terasaki Institute for Biomedical Innovation and UCLA Technology Development Group will co-curate an Advanced Organ and Tissue Repair (AToR) session at LABEST, featuring leading experts in regenerative medicine. The session aims to accelerate the translation of breakthrough technologies into real-world clinical solutions.
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.
Researchers create living tissue at near-physiological cell density using a new bioprinting strategy called embedded 3D printing in a cell-dense suspension (EPICS). The method enables the precise fabrication of perfusable channels and dense cellular environments, mimicking real organs.
Engineered tissue grafts can take on the liver's function and help patients with liver failure. The injected cells remain viable in the body for at least two months, generating enzymes and proteins like normal hepatocytes.
A research team from Xi'an Jiaotong University has developed a method to align cells in muscle tissue using electric forces during electrohydrodynamic bioprinting. This breakthrough allows for the creation of living muscle tissues with tightly aligned cells, enabling the production of functional muscle constructs.
Researchers explore piezoelectric electrospun fibers that generate crucial electrical signals for tissue engineering and biomedical applications. These "smart" scaffolds have high flexibility, biomimetic structure, and tunable morphology, offering potential for enhanced tissue repair.
Researchers create detailed 3D reconstructions of human liver tissue, comparing healthy and cirrhotic livers, showing dysregulation of metabolite transport, reduced specialized cells, and disruption of vascular networks. The study highlights the importance of understanding organ structure for bioprinting artificial organs.
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers at Kyushu University discovered that cancer cells use a previously unrecognized physical mechanism called CODE to create water pressure that aids in their migration. This finding opens new avenues for therapies targeting amoeboid movement, a key strategy used by most advanced cancer cells.
Researchers developed smart 4D-printed vascular stents that expand naturally at body temperature, eliminating the need for external heating. The stents balance mechanical flexibility and radial strength, demonstrating long-term biomechanical compliance.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
The EMBL-IBEC conference brings together experts to discuss recent breakthroughs in multicellular living systems, including organoids and embryonic development. The event will focus on disease modeling, developmental biology, and regenerative medicine applications.
A multidisciplinary team of world-leading experts is developing an off-the-shelf engineered product that could address liver failure in millions of patients. The ImPLANT project aims to create synthetic biology-based gene circuits in human induced pluripotent stem cells to drive cell differentiation into all required liver cell types.
A Japanese research team has developed a biohybrid approach that works inside the body, transforming engineered skin into a visible indicator of internal biological states. The system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling.
Researchers at TU Wien developed a 3D bioprinting technique to create living biological tissue for studying skin diseases. The method offers a controlled and highly reproducible manner to produce tailor-made structures for different purposes, such as psoriasis and inflammatory models.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Scientists have created a complex tissue model of human bone marrow using only human cells, replicating the cellular complexity of the body's 'blood factory'. This breakthrough reduces the need for animal experiments in blood cancer research and potentially enables personalized therapies.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Researchers developed a new type of porous gel that solves the problem of dense gels hindering the passage of microbes and immune cells. The new material supported better growth and organisation of bone marrow cells and helped the formation of structures similar to blood vessels, allowing fluids and particles to flow more efficiently.
Dr. Johnson V. John has been appointed as a standing member of the NIH's Musculoskeletal Tissue Engineering (MTE) Study Section, ensuring innovative research receives support. His expertise in biomaterials and tissue engineering will contribute to national research priorities.
The RODIN project aims to discover the subtle key structural features that cells engrave into materials when they are driven to produce specific tissues. The team will learn from this 'architectural wisdom' of cells to design new generations of higher performance biomaterials.
Researchers have identified iron-manganese alloys as promising candidates for temporary bone fixation. These alloys combine strength, biocompatibility, and degradation properties, allowing them to support bone healing while degrading naturally. However, challenges remain, including controlling the release of manganese, which can pose t...
A new, fully degradable cranial clamp made from poly-L-lactic acid has been developed to address traditional fixation system drawbacks. The study compared its performance to Aesculap CranioFix through laboratory tests and a clinical trial involving 90 patients, showing improved safety and healing outcomes.
New review highlights advances in New Approach Methodologies and tissue engineering, offering powerful tools to study early stages of cancer development. Lab-grown models replicate human body environment, unlocking clues about cancer initiation. These models also support discovery of new biomarkers for earlier detection.
Researchers developed a scalable method to produce human kidney organoids, combining them with pig kidneys outside the body for transplantation. The transplanted organs functioned normally and showed no signs of damage or toxicity.
Researchers at ETH Zurich have successfully produced muscle tissue using a new biofabrication system called G-FLight in microgravity. The process enables rapid production of viable muscle constructs with similar cell viability and muscle fibers as those printed under gravity.
Global experts discuss the future of additive manufacturing in various applications, including bioprinting living tissues and creating smart consumer products. Researchers showcase advancements in machine learning, real-time sensing, and multi-material 3D printing.
Researchers are developing 'biohybrid robots' that flex and move using biological tissue, offering potential applications in medicine and industry. The field is advancing through advanced fabrication methods, such as 3D bioprinting and electrospinning, which enable precise control over muscle cells.
Researchers have discovered that seaweed can be used as a biocompatible material for tissue engineering, reducing the need for animal testing. The study found that decellularized seaweed scaffolds promote cell growth and are compatible with human cardiomyocytes.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
Researchers at Carnegie Mellon University's Ren lab have developed AggreBots, microscale living robots made from human lung cells that can be controlled to deliver therapeutic or mechanical interventions. The biobots use cilia, nanoscopic hair-like propellers, for movement and can be programmed to perform specific tasks.
Researchers developed a 3D printable bio-active glass that served as an effective bone replacement material, sustaining bone cell growth longer than regular glass and commercial products. The new bio-glass was made by combining silica particles and calcium ions, which induced bone cell formation.
A research team led by Professor Shikha Dhiman has discovered that the speed of receptors in model cell membranes plays a crucial role in binding to biomaterials. When ligands move at similar speeds, they can bind to receptors, enabling effective tissue engineering and medical applications.
Scientists have achieved a major breakthrough by 3D bioprinting miniature placentas, which can accurately replicate the human placenta. This technology has the potential to transform pregnancy research by allowing for the study of serious complications like preeclampsia.
Researchers at UMC Utrecht developed a new AI-powered printer called GRACE that can print implantable tissues with improved cell survival and functionality. The printer uses computer vision and laser-based imaging to design and print complex structures, including blood vessels and cartilage layers.
Researchers have created a human vascularized liver cancer-on-a-chip model to evaluate vessel remodeling and cell death in response to embolic agents. This innovative platform replicates the microenvironment of liver tumors, providing unprecedented insight into how tumors respond to embolization.
Researchers developed novel artificial bone scaffolds with high deformation recovery capabilities, exceeding those of natural bone and conventional metallic scaffolds. These scaffolds allow for flexible adjustments of properties like strength and modulus to meet specific implantation site requirements.
Researchers at Lehigh University and the Cleveland Clinic are developing a nonsurgical therapy for pelvic organ prolapse using drug-delivering nanoparticles. The treatment aims to delay or reverse matrix degradation, reducing the severity of POP in patients with earlier stages of the disorder.
Researchers from Japan and USA discover midline tissues use formation control to grow harmoniously, with the notochord leading elongation and adjacent tissues migrating together through fibroblast growth factor gradients and cell adhesion. Computer simulations confirm this mechanism is essential for synchronized tissue development.
Researchers at Columbia University School of Engineering and Applied Science developed a novel way to use light to control tissue folding in live embryos. By manipulating proteins that generate mechanical forces, they can now study 3D tissue biology outside developing embryos or build and control tiny machines made out of living biolog...
Catherine Whittington, a WPI researcher, has received a CAREER Award to develop laboratory models for the study of fibrosis in pancreas, skin, and uterine fibroids. The models will help researchers better understand factors at the cellular level that lead to fibrosis and how interventions can interrupt or reverse it.
A team of researchers created a 3D-bioprinted model of stenotic brain blood vessels to study the effects of abnormal flow patterns on endothelial cells. The model successfully replicated physiological conditions, including upregulation of inflammatory markers.