Articles tagged with Tissue Engineering
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The POLINA project will develop new materials and technologies for medical applications, aiming to revolutionize bioprinting for safer, smarter and affordable medical devices. The project will create micropatterned cell surface models to help study lung diseases and design new tracheal implants.
Researchers from Tsinghua University provide an overview of biofabrication methods for single-cell feature building blocks to reconstruct engineered living systems. The techniques aim to replicate natural tissues with precise control over microenvironment and structure, benefiting biomedicine applications.
Engineers use module assembly to develop vascularized organotypic tissues with high cell density and well-organized vasculature. This approach enables the rapid generation of functional tissue substitutes with improved efficacy in treating diseases.
Scientists at UNSW Sydney have created a new material that can mimic human tissue, fight bacteria, and heal itself. The hydrogel material is made from simple peptides and has implications for biomedical research, medicine, and manufacturing technology.
Scientists from Central South University develop a novel approach to address bacterial infection in bone transplantation by enriching H2O2 and amplifying the Fenton reaction. The technique enhances biocompatibility and safety, promising reduced transplant failures and post-operative complications.
A new method for studying cancer cells' behavior on soft and stiff tissue environments has been developed, revealing crucial survival cues for cell growth. The study challenges the long-held assumption that cells prefer stiffer surfaces, opening up new possibilities for research in cancer biology and tissue engineering.
Researchers from Osaka University have developed a bioprinting technique that enables the creation of complex soft tissue structures with high fidelity. The method uses a printing support to facilitate gelation of a bioink, resulting in cell viability and viability for up to two weeks.
Researchers at Northwestern University developed Lattice, a device that simulates human disease in multiple organs to analyze interactions and test new drugs. The technology can replicate complex disease processes, allowing scientists to study the effects of obesity on endometrial cancer, for example.
Researchers at UNIST developed a microfluidic system to process blood into artificial tissue scaffolds for vascular regeneration. Autologous blood-based implants demonstrated superior wound closure rates, increased epidermis thickness, and enhanced collagen deposition in rodent skin wounds.
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
Researchers successfully recreated lung cancer patient's internal environment using hydrogel and 3D bioprinting, preserving specific lung cancer subtype and genetic mutation characteristics. The study enables precise drug evaluation and personalized treatment options for lung cancer patients with underlying diseases.
A miniature human heart model, approximately half a grain of rice in size, has been developed to transform drug testing and cardiovascular research. This self-paced, multi-chambered model provides real-time measurements of essential parameters, enabling unprecedented insights into heart function and diseases.
University of Melbourne researchers developed a novel approach to 'tissue engineering' blood vessels by combining multiple materials and fabrication technologies. The method creates blood vessels with complex geometries like native blood vessels, offering a transformative solution for cardiovascular disease.
Researchers at UC San Diego report new direct evidence of atrophy and fibrosis in pelvic floor muscles of women with symptoms of pelvic organ prolapse. They also showed that an acellular injectable skeletal muscle extracellular matrix hydrogel reduces the negative impact of simulated birth injury on rat pelvic floor muscles.
Researchers at Harvard developed a fiber-infused ink that allows 3D-printed heart muscle cells to align and contract like human heart cells, enabling the creation of functional heart ventricles. The innovation can be used to build life-like heart tissues with thicker muscle walls, paving the way for regenerative therapeutics.
A University College Dublin researcher has received a European Research Council Proof of Concept grant to investigate the disruptive power of macromolecular crowding in cell culture systems. The project aims to develop novel approaches for regenerative medicine by accelerating tissue development and improving therapeutic potential.
The PULSE project combines magnetic and acoustic levitation to bioprint highly sophisticated organoids that closely mimic human organs. These in vitro heart models will provide invaluable insights into cardiac physiology and pathology, enabling the development of preventive and therapeutic solutions.
A team from Tokyo Medical and Dental University has developed a technique to improve bone regeneration over large areas in rats, using vascular endothelial growth factor (VEGF) and Runx2. The combination of these two RNAs led to better regenerative responses in bone cells than each RNA alone.
Researchers from Tokyo Medical and Dental University successfully generated functional parathyroid glands from mouse embryonic stem cells using blastocyst complementation. This breakthrough study demonstrates the potential for regenerating organs in vivo and provides a new treatment option for hypoparathyroidism.
Researchers developed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering, demonstrating potential for clinical applications. The scaffolds can reconstruct desired tissue EM through non-invasive ultrasonic stimulation, promoting cell adhesion and osteogenic differentiation.
A novel biomaterials-based approach enhances adoptive T cell therapy with cancer vaccine technology, providing strong and long-lasting effects against solid tumors. In mice carrying melanomas, SIVET enables fast tumor shrinking and long-term protection.
Researchers create a three-dimensional epithelial model that reproduces the human lip area, allowing for evaluation of cosmetic ingredients and products. The model's structure and differentiation mode are similar to those of actual human lip tissue.
The technique has the potential to overcome major shortcomings associated with conventional bioprinting, allowing real-time wound treatment and immediate anastomosis with native tissue. However, challenges remain, including integration with surrounding tissues and limited access to defect sites in articular joints.
Recent innovations in volumetric bioprinting by UMC Utrecht researchers enable faster and more clinically relevant printing of living tissues. By controlling chemical properties, the team creates smart materials that guide cell behavior and development, mimicking native biochemical environments.
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
Scientists have developed an innovative platform using engineered human tissue to study how pathogens carried by mosquitoes impact and infect human cells. This breakthrough holds promise for studying other disease vectors like ticks, which spread Lyme disease.
Researchers at UMC Utrecht successfully merged two printing techniques to create functional tissues made from stem cells. Granular biogels enable high cell density, survival, and specialization, surpassing solid gels. This breakthrough boosts tissue functionality and opens up opportunities for regenerative medicine.
Researchers at the University Medical Center Utrecht combined volumetric bioprinting and melt electrowriting to create functional blood vessels. The technique allowed for the creation of tubes, forked vessels, and even venous valves with unidirectional flow, paving the way for further development into a fully functional blood vessel.
A University of Virginia-led study challenges traditional understanding of associative polymers' behavior, revealing that reversible bonds slow down polymer movement without creating a rubbery network. This discovery has implications for materials used in sustainability, health, and engineering applications.
Biomedical engineers at UTS have developed an intervertebral disc-on-a-chip, a precision-engineered toolbox for low back pain studies. The device simulates the complex mechanobiology of native tissue, enabling accurate evaluation of experimental methods for treatment or regeneration.
A new method for producing biocompatible microfibres with controlled size and shape has been developed at Graz University of Technology, significantly accelerating production and reducing costs. This breakthrough enables the potential for accelerated production of autologous skin and organs, which could be a game-changer for burn victi...
Researchers at POSTECH have developed a bioink using alginate from algae and visible light, resulting in enhanced cell viability and printing resolution. This innovation could lead to the creation of artificial organs and tissues, as well as cultivated meat with lower environmental impact.
Scientists adapted volumetric bioprinting to create three-dimensional, biologically functional areas within printed gels. The technique enables the infusion of biomolecules and growth factors into gelatin structures, creating a chemical map that guides cells to develop or specialize accordingly.
A multi-institutional team of experts is studying how to use focused ultrasound to create a temporary gateway through the blood-brain barrier to deliver cancer medicine. Researchers aim to develop a personalized medicine approach in which they can test drugs on patient tumors and predict treatment effectiveness.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
The PRISM-LT project aims to create an adaptable platform for 3D bioprinting of living tissue with dynamic functionalities and predictable shapes, using a novel tunable bioink that fosters a symbiotic relationship between stem cells and microorganisms.
Researchers at Linköping University developed a nanocellulose wound dressing that reveals early signs of infection through pH monitoring. This technology can lead to more efficient care and reduce unnecessary antibiotic use.
Scientists have developed a method to activate protein functions using brief flashes of light, enabling precise control over when and where chemical reactions occur. This technology has potential uses in tissue engineering, regenerative medicine, and understanding biological processes.
Scientists discover carbonated water's impact on low-methoxy pectin hydrogel formation and properties. The study shows that CO2 from carbonated water increases mechanical strength and gelation rate of hydrogels.
Researchers at the University of Bath have successfully created antimicrobial ferroelectric composite materials using a novel 3D printing process. These materials can eradicate E coli bacteria within 15 minutes, with potential applications in heart valves, stents, and bone implants.
Researchers created a three-dimensional structure that mimics bone and houses osteosarcoma cells beside immune cells, finding increased inflammation reduces chemotherapy effectiveness. The study highlights the importance of the tumor microenvironment in disease progression and treatment.
Scientists create hybrid composite scaffolds with aligned nanofibrous architectures to improve cell seeding efficiency, proliferation rates, and morphogenesis. The findings have potential applications in tissue repairing and regenerative medicine.
Researchers at NIST have developed a real-time technique to noninvasively count the number of live cells in a 3D artificial scaffold, meeting an unmet need in tissue engineering. The method uses optical coherence tomography and is label-free, reducing time and cost compared to earlier methods.
Researchers at University of Technology Sydney have successfully created personalized 'bio-inks' from patients' own stem cells, which are then used to 3D-print cardiac tissues to repair areas of dead tissue. This technology shows promise in treating heart failure and may reduce the need for expensive and traumatic heart transplants.
A new 3D-printed scaffold made of a dissolvable polymer is shown to create nipples that maintain long-lasting projection, unlike previous reconstruction approaches. The device has the potential to improve breast reconstruction results and could be available for women undergoing mastectomy in the near future.
Alejandro Sánchez Alvarado is awarded the Vilcek Prize in Biomedical Science for his groundbreaking work on regeneration. His research has significant implications for understanding cellular and organismal regeneration, with potential for further breakthroughs.
Researchers at UC San Diego develop new bioink with iodixanol, reducing light scattering and enabling high cell density printing. The technique creates functional human-like tissues with improved resolution and perfusion systems for long-term culture.
A research team at Chinese Academy of Sciences creates a spinal cord-like implant with covalent conjugation between biomaterials and cells, promoting cell retention and neural regeneration in rats after spinal cord injury. The study's findings have potential implications for human spinal cord tissue engineering therapy.
Researchers at Rice University have developed a self-assembling peptide ink that enables the 3D printing of complex structures with cells, which can then be used to grow mature tissue in a petri dish. The ink allows for control over cell behavior using structural and chemical complexity.
A Korean joint research team has developed a new tissue adhesive that restores damaged corneas by filling them and exposing them to light, potentially treating cornea ulcers without surgical interventions. The new sealant integrates well with adjacent tissues and promotes scar-free corneal tissue reconstruction.
Researchers at Aarhus University are developing a novel treatment for multiple sclerosis by spinning artificial nerve fibers using electro-spun fibres. The goal is to restore nerve impulses quickly, as the myelin sheath deteriorates with age.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
The NSF is funding projects that utilize the International Space Station (ISS) National Laboratory to advance tissue engineering and mechanobiology research. This solicitation aims to further drug discovery and therapeutic development through space-based research, with potential impacts on regenerative medicine and disease diagnosis.
The study successfully synthesised hybrid biomaterials using nanoparticles and showed excellent stem cell attachment and growth on the scaffolds. The material also promoted axonal cell migration towards the site of spinal cord injury, reducing scarring and inflammation. This research holds promise for treating spinal cord injuries.
Researchers from Yokohama National University successfully generated hair follicles in cultures using organoid cultures. The study demonstrates the potential of hair follicle organoids for understanding hair follicle development and regeneration, as well as evaluating drugs for treating hair loss disorders.
Researchers aim to develop scalable, modular manufacturing platform for growing new tissues from component parts, accelerating their fabrication and use. The goal is to assemble functional constructs that restore or improve damaged tissues or whole organs.
Researchers discuss benefits of using humanoid musculoskeletal robots and soft robotic systems as bioreactor platforms for producing clinically useful tendon constructs. These systems provide physiologically relevant mechanical stimulation, overcoming the translational gap in current conventional bioreactors.
Researchers at POSTECH have developed a method to engineer organs at scale using bioprinting, overcoming previous limitations of small tissue size and functional complexity. This innovation holds promise for personalized treatment of patients with the potential to create more realistic engineered organs.
Researchers from UMass Amherst have created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue. This breakthrough device has the potential to lead-edge applications in cardiac-disease experiments and improve health monitoring for cardiac disease studies.
Researchers at Karolinska Institutet have developed a method to create a three-dimensional gel from spider silk proteins that can be designed to deliver functional proteins. The gel has the potential to revolutionize regenerative medicine, enabling controlled drug release and tissue engineering applications.