Articles tagged with Tissue Engineering
Alastair Sloan, Head of School at the Melbourne Dental School, has received the 2021 IADR Isaac Schour Memorial Award for his significant contributions to tissue engineering and dental biology. He was recognized for his work on regeneration of mineralized tissues and behavior of dental pulp stem cells.
Researchers at Emory University developed a shape-shifting nanomaterial made of synthetic collagen that can be triggered to change its form from flat sheets to tubes and back again. The material has biomedical applications such as controlled-release drug delivery and tissue engineering.
Researchers developed a multidimensional model of trophoblast motility using a functionalized gelatin hydrogel. The study revealed that EGF and TGF-beta1 play critical roles in modulating trophoblast motility, providing insights into implantation mechanisms during normal and complex pregnancies.
Researchers developed an algae-based 3D bioprinting method to incorporate vascular patterns within engineered tissues and provide a sustainable source of oxygen for human cells. The approach showed promise for applications in disease modeling, drug development, regenerative and personalized medicine.
A University of Sydney team has developed a plasma technology to attach hydrogels to polymeric materials, allowing for better interaction with surrounding tissue. The technology has shown promising results in tests using biomolecules found in the body.
Researchers at the University of Nevada, Reno have engineered thale cress to improve water-use efficiency and salinity tolerance, a trait that can be applied to other plants to address future food shortages and climate change impacts.
A new combination of 3D printing and acoustic droplet ejection technology enables precise control over growth factor presentation, promoting osteogenic differentiation in C2C12 mouse myoblast cells. This technique has vast potential for various tissue types beyond bone engineering.
Researchers created an electrospun fiber blending protein and polymer, demonstrating gradual protein release. The study showcases the versatility of blended mats for biomedical applications like burn dressings, drug delivery, and tissue engineering.
Researchers develop combined technique to restore damaged intervertebral discs, improving hydration and structural integrity of the nucleus pulposus. The method also repairs damaged annulus fibrosus tissue, suggesting a potential strategy for improving outcomes in discectomy patients.
Scientists are developing novel tissue engineering techniques using everyday materials such as ice, eggshells, and spinach. These biomaterials are more functional, sustainable, and cost-effective than traditional methods.
A study directly compares chondrogenic induction by hydrogels containing MSCs as either single cell suspensions or 100-500-cell micropellets. The results show that micropellet-encapsulated MSCs outperform single cells in cartilage regeneration, providing guidance for future cartilage engineering efforts.
North Carolina State University researchers have created a technique called ultrasound-assisted biofabrication (UAB) to align living cells during the bioprinting process. This allows for the creation of tissues with characteristics similar to natural tissues, such as a knee meniscus with aligned cell structures.
A team of biomedical engineers has developed a stem cell cardiac patch made with tissue engineered with tiny blood vessels to mimic real heart muscle. The patch can connect to native vasculature, bringing nutrients and oxygen, making it potentially effective for treating myocardial infarction.
A new study reveals that pulsed electromagnetic fields (PEMFs) increase osteoblast precursor cell proliferation and induce osteogenic gene expression, but do not enhance calcium deposition. Careful selection of PEMF parameters is crucial for inducing a favorable effect.
Scientists developed a hybrid biosensor scaffold material based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. This allows visualization of cell growth and metabolism in engineered tissues by microscopy. The study was published in Acta Biomaterialia and has promising prospects for regenerative medicine.
Researchers highlight advancements in electrospinning for use in rotator cuff tissue engineering, focusing on improving nano-topographical properties and mechanical strengths. Human tissue is used to determine cyto-compatibility, but outcome measures vary across studies.
Chondral defects are common, with slow self-healing properties of articular cartilage limiting treatment effectiveness. Cartilage tissue engineering offers new hope for patients, using various scaffold materials and preparation techniques to treat chondral defects.
Researchers have created biomaterials that combine ordered and disordered segments to form a stable, porous scaffold that promotes cell growth and vascularization. The material's unique properties enable it to integrate into tissue with minimal inflammation and hold its volume well.
Researchers at Peter the Great St. Petersburg Polytechnic University create three-dimensional porous material made of collagen and chitosan to restore bone tissue after trauma or illness. The material stimulates natural tissue growth, eliminating the need for lifelong medication.
Researchers developed a cartilage matrix that mimics early stages of repair and provides necessary structural properties for bone-forming cells. The decellularized cartilage-based scaffold effectively directs chondrogenic differentiation and creates a fracture callus mimetic.
A new guide provides comprehensive overview of mechanical stimulation techniques for enhancing tissue-engineered articular cartilage. The review highlights the effects of various loading parameters on AC properties, including direct compression, hydrostatic pressure, shear, and tensile loading.
Prellis Biologics has developed record speed and resolution technology for printing human tissue with viable capillaries, a major hurdle in organ engineering. This breakthrough enables the production of thick, functioning tissue for drug testing and ultimately human organs.
Scientists have created a new hydrogel adhesive made from two naturally derived polymers that is 15 times stronger than traditional adhesives used for nerve reconstruction. The material supports cell survival, extension, and proliferation essential for nerve regeneration in vitro and in animal models.
Researchers used periodontal ligament-derived stem cells to create a cell sheet that promoted the formation of both cementum- and PDL-like tissue in dogs. This innovative work combines traditional dental implants with stem cell sheet technology, offering a promising solution for widespread dental health care issues.
Researchers at Columbia University created adult-like cardiac model using induced pluripotent stem cells with electric and mechanical stimulation. The resulting tissue mimics the human heart's behavior after just four weeks of culture.
The National Institutes of Health (NIDCR) established the DOCTRC Program to develop resources and strategies for regenerating dental, oral, and craniofacial tissues. Two national resource centers were established: The Michigan-Pittsburgh-Wyss Resource Center and the Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration.
Prellis Biologics has received $1.8 million in funding to develop patent-pending technologies for creating viable human organs using 3D printing. The company aims to solve the challenge of creating microvasculature, a crucial component of functional organs.
Researchers found that the success of transplanting stem cells into the brain to regenerate tissue damaged by stroke depends on the maturity of the neuronal precursor cells used. Mid-differentiated cells were most likely to mature and become neurons, according to the study published in Tissue Engineering.
The Center will develop new technologies and serve as a collaborative hub for surgeons, biomaterials experts, and engineers focused on regenerative medicine. The center aims to create functional constructs that restore, maintain or improve damaged tissues or organs.
Researchers successfully grow human heart cells on spinach leaves by perfusing fluids and microbeads through the plant's vascular system, paving the way for using multiple leaves to treat heart attack patients. The technique could also be adapted for other tissues, such as bone engineering.
Researchers have grown engineered heart tissue using a 3-D printer, improving heart function and decreasing dead tissue after a heart attack. The novel technique holds promise for the clinical use of 3-D-printing technology in preventing heart failure after a heart attack.
Researchers developed a mouse model to assess early tissue responses to biomaterials, including bioactive glass. The model's feasibility and reliability have been demonstrated using various biomaterials, enabling the design of novel biomaterials for regenerative medicine.
Researchers developed biocompatible scaffolds with controlled-release silver ions to inhibit MRSA bone infection. The antimicrobial properties of silver combined with bone-forming stem cells offer a potential implant system for treating and preventing bone infections.
Breast cancer cells may use mesenchymal stem cells in bone marrow to spread to bone tissue. A study using a 3D scaffold model found that tumor-derived factors can promote maturation of MSCs into bone cells, with mechanical compression stimulating further bone development.
Researchers at RIT are developing new, ultrathin, transparent glass membranes for in vitro tissue models and barrier cell studies. These membranes will enable easier physical and biochemical communication between cells, advancing tissue engineering and drug discovery.
A new study introduces a novel hybrid polymer for producing 3D-printed scaffolds suitable for seeding living cells, enabling the creation of engineered tissues. The researchers successfully fabricated scaffolds using commercial 3D printers and demonstrated high cell survival rates.
A Pittsburgh researcher has received a grant to study the effects of prolonged space travel on bones using a 3D microphysiological system. The research aims to develop new treatments for osteoporosis and enhance personalized medicine.
Researchers are developing a custom-engineered tissue patch using robotic 3-D printing and computer-assisted manufacturing. The patch aims to replace or protect damaged heart muscle after a heart attack, offering new hope for patients with post-infarction left ventricle remodeling and heart failure.
The FDA draft guidelines aim to restrict the use of human cell and tissue products in various surgical procedures, potentially hindering the development of new therapies. This could impact surgeons performing reconstructive surgeries, such as breast, chest, and abdominal wall reconstructions, as well as pelvic floor reconstruction.
A new bone marrow-on-a-chip device mimics living bone marrow's response to radiation exposure and treatment, enabling the testing of experimental drugs. This innovation holds promise for improving radiation countermeasures.
Researchers developed clay nanotube-biopolymer composite scaffolds that improve mechanical strength, water uptake, and thermal properties. The scaffolds demonstrated enhanced biocompatibility and encouraged cell adhesion, proliferation, and neo-vascularization in vitro and in vivo.
Researchers at the University of Missouri-Columbia have developed new methods for creating human tissues using textile manufacturing processes. These methods, which include meltblowing, spunbonding, and carding, proved more cost-effective than traditional electrospinning techniques, with costs ranging from $0.30 to $3.00 per meter.
Using 3D bioprinting, Griffith University researchers are developing a new method to replace missing teeth and bone using totally bespoke tissue engineered components. The approach aims to reduce the risks of complications and provide a more invasive-free alternative.
The article highlights regional differences in demographics, disease prevalence, and cultural attitudes towards donated tissues and organs. Regulatory approaches vary across countries, necessitating a tailored approach to balance risk and benefit.
Researchers examine human digit healing and regenerative potential, identifying key components required for complex tissue development. The goal of epimorphic regeneration, which would enable humans to grow entire limbs, is considered a radical approach that could transform prognosis and quality of life for amputees.
A team of researchers from UCLA has developed biomaterial coatings that alter cell proliferation and attachment. The coatings, which include collagen and heparan sulfate, were found to improve cell survival after implantation by promoting blood vessel development. This breakthrough could lead to the creation of functional tissues for t...
Scientists have created engineered liver tissue that closely mimics the real thing, with a metabolic rate closer to real-life levels than existing models. The new approach successfully simulated how a real liver would react to various drug combinations.
A review article discusses novel tissue engineering approaches to repair spinal disc herniation, targeting underlying disc injury or instability. The emerging biological repair methods show promising preclinical outcomes, potentially reducing pain and restoring spine motion.
Researchers developed a high-throughput screening method to characterize and select multipotent cells from adipose-derived stromal cells (hASCs) using flow cytometry. This approach can identify specific cell types advantageous for regenerative medicine and tissue engineering applications.
A new study demonstrates the ability to apply a thin coating of viable respiratory epithelial cells to tissue engineered constructs using a commercially available spray device, providing a promising approach for repairing or replacing challenging structures like trachea or bronchi. The effects of air pressure and nozzle diameter on cel...
Researchers found that implanting a biomaterial scaffold after spinal cord injury creates a favorable environment for nerve regeneration. Seeding Schwann cells had no significant effect on the lesion environment.
The International Association for Dental Research published a case report on the first application of 3D printed scaffolds for periodontal tissue engineering in humans. A review also discussed various 3D bioprinting methods, biomaterials, and their potential applications.
Researchers discovered that controlling the innate immune system's reaction to tissue-engineered vascular grafts can reduce abnormal narrowing and increase graft performance. The study sets the stage for developing safe and effective vascular grafts for congenital heart disease treatment.
Researchers have developed a novel synthetic material that can self-assemble into nanostructures to support tissue growth and ultimately degrade. This biofunctional coating stimulates the formation of complex tissues, offering a promising approach to deliver cell and tissue therapies.
A team of researchers is working on a five-year program to create a bioreactor that more closely simulates the complex tissues and dynamic movements of the intestinal track. This project aims to deliver a simple, easy-to-use and relatively inexpensive system for infectious disease labs.
Researchers developed a new device, Bio-P3, to create and assemble 3D tissue constructs densely packed with living cells. The device can pick up, transport, and release multi-cellular microtissues with minimal effects on cell viability.
A team of researchers used MakerBot's 3D printing technology to create a custom tracheal scaffolding, combining it with living cells to form a functional airway segment. The breakthrough has the potential to revolutionize tracheal repair and replacement procedures.
Researchers at Children's Hospital Los Angeles developed a tissue-engineering technique to grow an entire esophagus from human cells on a biodegradable scaffold. This breakthrough may lead to new treatments for children born with missing portions of the organ, as well as patients who have had esophageal cancer or damaged tissue.
Researchers at Brown University have developed a method to clear 3-D cell cultures, allowing for clearer imaging and analysis of neural tissues. The ClearT2 method works within 1.5 hours and preserves the size of the tissue, making it ideal for studying neural growth and development.
The University of Chicago is creating a new professorship in tissue engineering, supported by a $3.5 million donation from the Millicent and Eugene Bell Foundation. This endowed chair will foster scholarship on tissue engineering at the MBL and Institute for Molecular Engineering.