Articles tagged with Tissue Engineering
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
A team from Tokyo Medical & Dental University has created a jigsaw-shaped peptide that functions as an extracellular matrix for injured tissue regeneration. The peptide's ability to incorporate and release growth factors stimulates cell growth and vascular formation, showing promise in regenerating tissues.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
A new study from Princeton University shows how the brown anole lizard solves breathing problems with crude yet effective lobes covered in bulbous protuberances. The lizard's lung development is achieved through a physical mechanism that allows for rapid growth and gas exchange.
Scientists from Tokyo Medical and Dental University create polyrotaxane-based biomaterials that improve epithelial cell-cell adhesion, enabling the repair of damaged tissues. The study suggests a potential application in clinical dentistry for treating periodontal disease.
Researchers discovered that mechanical forces guide cell development, influencing gene expression and potentially leading to pathologies like heart disease. The findings could inspire advances in engineering authentic artificial tissue for medical applications.
Researchers at Technion and Sheba Medical Center have developed a new technology for fabricating custom-made ear implants for microtia patients. The biodegradable auricle scaffold is 3D-printed using the patient's own cells, reducing the risk of complications and discomfort associated with traditional methods.
Researchers at Lehigh University are working on a project funded by the Good Food Institute grant to adapt human tissue engineering techniques for growing meat in the lab. The team is developing a scaffold for meat cells to grow on and using electrochemistry, nanomaterial design, and liposomal delivery vehicles to promote fibrous growth.
A team of researchers led by Guy Genin and Stavros Thomopoulos found a previously unknown fibrous architecture in the shoulder joint, revealing new features of the attachment system. The discovery sheds light on how the rotator cuff functions and why repairs fail frequently.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
Researchers aim to replicate natural tendon development using embryonic chicken and mouse models, with a focus on mechanical stimulation and nanoparticle design.
A team of Montreal researchers has created a new method of bioprinting adult neuron cells using Laser-Induced Side Transfer (LIST) technology. The technique successfully prints sensory neurons, which are vital for the peripheral nervous system, and shows promise for drug discovery, disease modeling, and implant fabrication.
Researchers will explore ways to regenerate damaged salivary glands and understand vocal fold scarring, aiming to develop new treatment options for head and neck cancer patients. The project includes creating a vocal-fold-on-a-chip model with embedded sensor technology to monitor tissue development in real-time.
Caltech researchers have developed a technique to build embryo-like structures from human stem cells, opening up new possibilities for studying early human development. The technology can generate large quantities of these structures without the need for donated embryos.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
Researchers from the University of Basel have found that nasal cartilage cells can withstand chronic inflammatory conditions and counteract inflammation in osteoarthritis. The approach involves using engineered cartilage tissue to repair or replace damaged joints, offering a promising alternative to joint prostheses.
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.
Researchers developed a pollen-based hybrid ink that can be used to fabricate parts useful for tissue engineering, toxicity testing and drug delivery. The ink is biocompatible, flexible and low in cost, allowing for the creation of customized flexible membranes tailored to human skin contours.
Researchers have developed a special polymer to coat blood vessels on transplanted organs, reducing rejection rates in mice by substantially diminishing immune system response. The breakthrough has the potential to eliminate the need for drugs that prevent organ rejection and improve transplant outcomes.
Rice University bioengineers are developing an insulin-producing implant to regulate blood glucose levels in Type 1 diabetics. The implant uses human stem cells and 3D printing to mimic the natural behavior of the pancreas, with the goal of achieving consistent target blood glucose levels.
Alastair Sloan, Head of School at the Melbourne Dental School, has received the 2021 IADR Isaac Schour Memorial Award for his significant contributions to tissue engineering and dental biology. He was recognized for his work on regeneration of mineralized tissues and behavior of dental pulp stem cells.
Researchers at Emory University developed a shape-shifting nanomaterial made of synthetic collagen that can be triggered to change its form from flat sheets to tubes and back again. The material has biomedical applications such as controlled-release drug delivery and tissue engineering.
Researchers developed a multidimensional model of trophoblast motility using a functionalized gelatin hydrogel. The study revealed that EGF and TGF-beta1 play critical roles in modulating trophoblast motility, providing insights into implantation mechanisms during normal and complex pregnancies.
Researchers developed an algae-based 3D bioprinting method to incorporate vascular patterns within engineered tissues and provide a sustainable source of oxygen for human cells. The approach showed promise for applications in disease modeling, drug development, regenerative and personalized medicine.
A University of Sydney team has developed a plasma technology to attach hydrogels to polymeric materials, allowing for better interaction with surrounding tissue. The technology has shown promising results in tests using biomolecules found in the body.
Researchers at the University of Nevada, Reno have engineered thale cress to improve water-use efficiency and salinity tolerance, a trait that can be applied to other plants to address future food shortages and climate change impacts.
A new combination of 3D printing and acoustic droplet ejection technology enables precise control over growth factor presentation, promoting osteogenic differentiation in C2C12 mouse myoblast cells. This technique has vast potential for various tissue types beyond bone engineering.
Researchers created an electrospun fiber blending protein and polymer, demonstrating gradual protein release. The study showcases the versatility of blended mats for biomedical applications like burn dressings, drug delivery, and tissue engineering.
Researchers develop combined technique to restore damaged intervertebral discs, improving hydration and structural integrity of the nucleus pulposus. The method also repairs damaged annulus fibrosus tissue, suggesting a potential strategy for improving outcomes in discectomy patients.
Scientists are developing novel tissue engineering techniques using everyday materials such as ice, eggshells, and spinach. These biomaterials are more functional, sustainable, and cost-effective than traditional methods.
A study directly compares chondrogenic induction by hydrogels containing MSCs as either single cell suspensions or 100-500-cell micropellets. The results show that micropellet-encapsulated MSCs outperform single cells in cartilage regeneration, providing guidance for future cartilage engineering efforts.
North Carolina State University researchers have created a technique called ultrasound-assisted biofabrication (UAB) to align living cells during the bioprinting process. This allows for the creation of tissues with characteristics similar to natural tissues, such as a knee meniscus with aligned cell structures.
A team of biomedical engineers has developed a stem cell cardiac patch made with tissue engineered with tiny blood vessels to mimic real heart muscle. The patch can connect to native vasculature, bringing nutrients and oxygen, making it potentially effective for treating myocardial infarction.
A new study reveals that pulsed electromagnetic fields (PEMFs) increase osteoblast precursor cell proliferation and induce osteogenic gene expression, but do not enhance calcium deposition. Careful selection of PEMF parameters is crucial for inducing a favorable effect.
Scientists developed a hybrid biosensor scaffold material based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. This allows visualization of cell growth and metabolism in engineered tissues by microscopy. The study was published in Acta Biomaterialia and has promising prospects for regenerative medicine.
Chondral defects are common, with slow self-healing properties of articular cartilage limiting treatment effectiveness. Cartilage tissue engineering offers new hope for patients, using various scaffold materials and preparation techniques to treat chondral defects.
Researchers highlight advancements in electrospinning for use in rotator cuff tissue engineering, focusing on improving nano-topographical properties and mechanical strengths. Human tissue is used to determine cyto-compatibility, but outcome measures vary across studies.
Researchers have created biomaterials that combine ordered and disordered segments to form a stable, porous scaffold that promotes cell growth and vascularization. The material's unique properties enable it to integrate into tissue with minimal inflammation and hold its volume well.
Researchers at Peter the Great St. Petersburg Polytechnic University create three-dimensional porous material made of collagen and chitosan to restore bone tissue after trauma or illness. The material stimulates natural tissue growth, eliminating the need for lifelong medication.
Researchers developed a cartilage matrix that mimics early stages of repair and provides necessary structural properties for bone-forming cells. The decellularized cartilage-based scaffold effectively directs chondrogenic differentiation and creates a fracture callus mimetic.
Prellis Biologics has developed record speed and resolution technology for printing human tissue with viable capillaries, a major hurdle in organ engineering. This breakthrough enables the production of thick, functioning tissue for drug testing and ultimately human organs.
A new guide provides comprehensive overview of mechanical stimulation techniques for enhancing tissue-engineered articular cartilage. The review highlights the effects of various loading parameters on AC properties, including direct compression, hydrostatic pressure, shear, and tensile loading.
Scientists have created a new hydrogel adhesive made from two naturally derived polymers that is 15 times stronger than traditional adhesives used for nerve reconstruction. The material supports cell survival, extension, and proliferation essential for nerve regeneration in vitro and in animal models.
Researchers used periodontal ligament-derived stem cells to create a cell sheet that promoted the formation of both cementum- and PDL-like tissue in dogs. This innovative work combines traditional dental implants with stem cell sheet technology, offering a promising solution for widespread dental health care issues.
Researchers at Columbia University created adult-like cardiac model using induced pluripotent stem cells with electric and mechanical stimulation. The resulting tissue mimics the human heart's behavior after just four weeks of culture.
The National Institutes of Health (NIDCR) established the DOCTRC Program to develop resources and strategies for regenerating dental, oral, and craniofacial tissues. Two national resource centers were established: The Michigan-Pittsburgh-Wyss Resource Center and the Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration.
Prellis Biologics has received $1.8 million in funding to develop patent-pending technologies for creating viable human organs using 3D printing. The company aims to solve the challenge of creating microvasculature, a crucial component of functional organs.
Researchers found that the success of transplanting stem cells into the brain to regenerate tissue damaged by stroke depends on the maturity of the neuronal precursor cells used. Mid-differentiated cells were most likely to mature and become neurons, according to the study published in Tissue Engineering.
The Center will develop new technologies and serve as a collaborative hub for surgeons, biomaterials experts, and engineers focused on regenerative medicine. The center aims to create functional constructs that restore, maintain or improve damaged tissues or organs.
Researchers successfully grow human heart cells on spinach leaves by perfusing fluids and microbeads through the plant's vascular system, paving the way for using multiple leaves to treat heart attack patients. The technique could also be adapted for other tissues, such as bone engineering.
Researchers have grown engineered heart tissue using a 3-D printer, improving heart function and decreasing dead tissue after a heart attack. The novel technique holds promise for the clinical use of 3-D-printing technology in preventing heart failure after a heart attack.
Researchers developed a mouse model to assess early tissue responses to biomaterials, including bioactive glass. The model's feasibility and reliability have been demonstrated using various biomaterials, enabling the design of novel biomaterials for regenerative medicine.
Researchers developed biocompatible scaffolds with controlled-release silver ions to inhibit MRSA bone infection. The antimicrobial properties of silver combined with bone-forming stem cells offer a potential implant system for treating and preventing bone infections.
Breast cancer cells may use mesenchymal stem cells in bone marrow to spread to bone tissue. A study using a 3D scaffold model found that tumor-derived factors can promote maturation of MSCs into bone cells, with mechanical compression stimulating further bone development.
Researchers at RIT are developing new, ultrathin, transparent glass membranes for in vitro tissue models and barrier cell studies. These membranes will enable easier physical and biochemical communication between cells, advancing tissue engineering and drug discovery.
A new study introduces a novel hybrid polymer for producing 3D-printed scaffolds suitable for seeding living cells, enabling the creation of engineered tissues. The researchers successfully fabricated scaffolds using commercial 3D printers and demonstrated high cell survival rates.
A Pittsburgh researcher has received a grant to study the effects of prolonged space travel on bones using a 3D microphysiological system. The research aims to develop new treatments for osteoporosis and enhance personalized medicine.
Researchers are developing a custom-engineered tissue patch using robotic 3-D printing and computer-assisted manufacturing. The patch aims to replace or protect damaged heart muscle after a heart attack, offering new hope for patients with post-infarction left ventricle remodeling and heart failure.
The FDA draft guidelines aim to restrict the use of human cell and tissue products in various surgical procedures, potentially hindering the development of new therapies. This could impact surgeons performing reconstructive surgeries, such as breast, chest, and abdominal wall reconstructions, as well as pelvic floor reconstruction.
A new bone marrow-on-a-chip device mimics living bone marrow's response to radiation exposure and treatment, enabling the testing of experimental drugs. This innovation holds promise for improving radiation countermeasures.