Articles tagged with Tissue Engineering
Researchers have grown engineered heart tissue using a 3-D printer, improving heart function and decreasing dead tissue after a heart attack. The novel technique holds promise for the clinical use of 3-D-printing technology in preventing heart failure after a heart attack.
Researchers developed a mouse model to assess early tissue responses to biomaterials, including bioactive glass. The model's feasibility and reliability have been demonstrated using various biomaterials, enabling the design of novel biomaterials for regenerative medicine.
Researchers developed biocompatible scaffolds with controlled-release silver ions to inhibit MRSA bone infection. The antimicrobial properties of silver combined with bone-forming stem cells offer a potential implant system for treating and preventing bone infections.
Breast cancer cells may use mesenchymal stem cells in bone marrow to spread to bone tissue. A study using a 3D scaffold model found that tumor-derived factors can promote maturation of MSCs into bone cells, with mechanical compression stimulating further bone development.
Researchers at RIT are developing new, ultrathin, transparent glass membranes for in vitro tissue models and barrier cell studies. These membranes will enable easier physical and biochemical communication between cells, advancing tissue engineering and drug discovery.
A new study introduces a novel hybrid polymer for producing 3D-printed scaffolds suitable for seeding living cells, enabling the creation of engineered tissues. The researchers successfully fabricated scaffolds using commercial 3D printers and demonstrated high cell survival rates.
A Pittsburgh researcher has received a grant to study the effects of prolonged space travel on bones using a 3D microphysiological system. The research aims to develop new treatments for osteoporosis and enhance personalized medicine.
Researchers are developing a custom-engineered tissue patch using robotic 3-D printing and computer-assisted manufacturing. The patch aims to replace or protect damaged heart muscle after a heart attack, offering new hope for patients with post-infarction left ventricle remodeling and heart failure.
The FDA draft guidelines aim to restrict the use of human cell and tissue products in various surgical procedures, potentially hindering the development of new therapies. This could impact surgeons performing reconstructive surgeries, such as breast, chest, and abdominal wall reconstructions, as well as pelvic floor reconstruction.
A new bone marrow-on-a-chip device mimics living bone marrow's response to radiation exposure and treatment, enabling the testing of experimental drugs. This innovation holds promise for improving radiation countermeasures.
Researchers developed clay nanotube-biopolymer composite scaffolds that improve mechanical strength, water uptake, and thermal properties. The scaffolds demonstrated enhanced biocompatibility and encouraged cell adhesion, proliferation, and neo-vascularization in vitro and in vivo.
Researchers at the University of Missouri-Columbia have developed new methods for creating human tissues using textile manufacturing processes. These methods, which include meltblowing, spunbonding, and carding, proved more cost-effective than traditional electrospinning techniques, with costs ranging from $0.30 to $3.00 per meter.
Using 3D bioprinting, Griffith University researchers are developing a new method to replace missing teeth and bone using totally bespoke tissue engineered components. The approach aims to reduce the risks of complications and provide a more invasive-free alternative.
The article highlights regional differences in demographics, disease prevalence, and cultural attitudes towards donated tissues and organs. Regulatory approaches vary across countries, necessitating a tailored approach to balance risk and benefit.
Researchers examine human digit healing and regenerative potential, identifying key components required for complex tissue development. The goal of epimorphic regeneration, which would enable humans to grow entire limbs, is considered a radical approach that could transform prognosis and quality of life for amputees.
A team of researchers from UCLA has developed biomaterial coatings that alter cell proliferation and attachment. The coatings, which include collagen and heparan sulfate, were found to improve cell survival after implantation by promoting blood vessel development. This breakthrough could lead to the creation of functional tissues for t...
Scientists have created engineered liver tissue that closely mimics the real thing, with a metabolic rate closer to real-life levels than existing models. The new approach successfully simulated how a real liver would react to various drug combinations.
A review article discusses novel tissue engineering approaches to repair spinal disc herniation, targeting underlying disc injury or instability. The emerging biological repair methods show promising preclinical outcomes, potentially reducing pain and restoring spine motion.
Researchers developed a high-throughput screening method to characterize and select multipotent cells from adipose-derived stromal cells (hASCs) using flow cytometry. This approach can identify specific cell types advantageous for regenerative medicine and tissue engineering applications.
A new study demonstrates the ability to apply a thin coating of viable respiratory epithelial cells to tissue engineered constructs using a commercially available spray device, providing a promising approach for repairing or replacing challenging structures like trachea or bronchi. The effects of air pressure and nozzle diameter on cel...
Researchers found that implanting a biomaterial scaffold after spinal cord injury creates a favorable environment for nerve regeneration. Seeding Schwann cells had no significant effect on the lesion environment.
The International Association for Dental Research published a case report on the first application of 3D printed scaffolds for periodontal tissue engineering in humans. A review also discussed various 3D bioprinting methods, biomaterials, and their potential applications.
Researchers discovered that controlling the innate immune system's reaction to tissue-engineered vascular grafts can reduce abnormal narrowing and increase graft performance. The study sets the stage for developing safe and effective vascular grafts for congenital heart disease treatment.
Researchers have developed a novel synthetic material that can self-assemble into nanostructures to support tissue growth and ultimately degrade. This biofunctional coating stimulates the formation of complex tissues, offering a promising approach to deliver cell and tissue therapies.
A team of researchers is working on a five-year program to create a bioreactor that more closely simulates the complex tissues and dynamic movements of the intestinal track. This project aims to deliver a simple, easy-to-use and relatively inexpensive system for infectious disease labs.
Researchers developed a new device, Bio-P3, to create and assemble 3D tissue constructs densely packed with living cells. The device can pick up, transport, and release multi-cellular microtissues with minimal effects on cell viability.
A team of researchers used MakerBot's 3D printing technology to create a custom tracheal scaffolding, combining it with living cells to form a functional airway segment. The breakthrough has the potential to revolutionize tracheal repair and replacement procedures.
Researchers at Children's Hospital Los Angeles developed a tissue-engineering technique to grow an entire esophagus from human cells on a biodegradable scaffold. This breakthrough may lead to new treatments for children born with missing portions of the organ, as well as patients who have had esophageal cancer or damaged tissue.
Researchers at Brown University have developed a method to clear 3-D cell cultures, allowing for clearer imaging and analysis of neural tissues. The ClearT2 method works within 1.5 hours and preserves the size of the tissue, making it ideal for studying neural growth and development.
The University of Chicago is creating a new professorship in tissue engineering, supported by a $3.5 million donation from the Millicent and Eugene Bell Foundation. This endowed chair will foster scholarship on tissue engineering at the MBL and Institute for Molecular Engineering.
Researchers at Columbia University successfully grew fully functional human cartilage from adult human stem cells, marking a significant breakthrough in tissue engineering. The developed cartilage exhibits physiologic architecture and strength, with potential applications in repairing cartilage defects or reconstructing complex tissues.
Researchers at Karolinska Institutet successfully transplanted a regenerated esophagus into rats, showing regeneration of nerves, muscles, epithelial cells and blood vessels. The breakthrough could improve survival and quality of life for patients with oesophageal disorders.
Researchers at Harvard Medical School and University of Sydney develop elastic hydrogel-based cardiac tissue that beats in synchrony with natural heart muscle. The breakthrough could lead to repairing damaged hearts without organ transplants, revolutionizing the treatment for millions worldwide.
Researchers at the University of California, Berkeley, used electrical current to direct the movement of epithelial cells, a breakthrough that could lead to controlled forms of tissue engineering. The study demonstrates the potential for 'smart bandages' that use electrical stimulation to aid wound healing.
A new micro-robotic technique allows for precise construction of individual cell-encapsulating hydrogels, enabling true control over bottom-up tissue engineering. This breakthrough has the potential to revolutionize 3D printing and tissue engineering, addressing organ shortages and improving disease treatment.
Researchers have created an engineered cardiac tissue model using human embryonic stem cells, which exhibits significant similarities to human heart muscle. The model displays spontaneous contractile activity and responds to electrical stimulation, providing a promising platform for developing reliable models of the human heart.
A new 3-D phase contrast X-ray imaging system will help evaluate and monitor bioengineered tissues in a living body. The technique addresses limitations of conventional X-ray imaging technologies.
Researchers developed a novel biomimetic tissue engineered bone graft that successfully repaired bone defects in rabbits. The graft, consisting of rabbit adipose derived stem cells and a porous beta-tricalcium phosphate scaffold, promoted osteogenesis and was biocompatible.
A 30-year-old Colombian mother received a tissue-engineered trachea in 2008, and five years later, she continues to enjoy a good quality of life without immunological complications or rejection. Regular testing reveals retained lung function and no scarring, although some symptoms remain monitored through bronchoscopies.
Researchers at Tel Aviv University have developed spring-like fibers to engineer cardiac tissue that can pump more like the real thing. The new fibers show improved elasticity and contraction force compared to straight fibers, holding promise for repairing damaged heart tissue.
Manuela E. Gomes, a Portuguese researcher, has received the 2013 TERMIS-EU Young Scientist Award for her contributions to tissue engineering and regenerative medicine. Her research focuses on bone and cartilage tissue engineering strategies, including scaffold materials, stem cells, and dynamic cell culturing systems.
Researchers discovered that low levels of a toxic protein may cause more harm than high levels in neurodegenerative diseases such as Alzheimer's. Short protein threads formed at low levels can lead to disease progression, whereas longer filaments are thought to be protective.
A novel thermo-sensitive injectable hydrogel engineered with gene modified bone marrow mesenchymal stromal cells (BMSCs) successfully repairs articular cartilage defects in rabbits. The study demonstrates the potential of tissue engineering combined with gene therapy for managing defective articular cartilage.
Researchers have made significant progress in engineering blue-green algae to produce nanocellulose, a 'wonder material' with great strength and potential applications in biofuels, biomaterials, and more. The team successfully engineered the algae to produce fully functional nanocellulose.
Scientists at the University of Granada have found that only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes. The researchers identified Wharton's jelly stem cells (HWJSC) as the most suitable subgroup, which can develop into several types of tissue and modulate immune responses.
Harvard scientists developed a method to grow 'cyborg' tissues by embedding nanoscale wires into engineered human tissues. They successfully seeded the networks with cells and encouraged them to grow in 3D cultures, enabling real-time monitoring and control of living systems.
A multi-institutional research team has developed a method for embedding networks of biocompatible nanoscale wires within engineered tissues. This allows direct tissue sensing and potentially stimulation, which could lead to the development of engineered tissues that incorporate capabilities for monitoring and stimulation.
University of Texas Medical Branch at Galveston researchers have been awarded a $1.25 million NIH grant to develop lab-grown lung tissue models for biomedical studies. These models could provide significant advantages over animal models, including reduced costs and the ability to study human responses more accurately.
Harvard University researchers have successfully created an artificial jellyfish using a silicone polymer and heart muscle cells. The Medusoid, as it's called, is capable of swimming and reproducing complex behaviors seen in biological jellyfish.
The tissue engineering and stem cell industries have experienced significant growth, with over half of companies generating revenue, up from 21% four years ago. Commercial products and services are driving the increase, with $3.5 billion in sales revenues and industry spending approaching $3.6 billion.
Researchers developed a new method to create 3D pancreatic beta-cell clusters that live longer and secrete more insulin than single cells. This breakthrough advances the study of pancreatic diseases like diabetes and enables testing of novel therapies.
New cell printing technology enables precise pattern formation of human cells, paving the way for advancement in tissue engineering and regeneration. Researchers demonstrated the use of acoustic droplet ejection followed by aqueous two-phase exclusion patterning to control cell placement.
Scientists have created a new buoyant material inspired by the water strider's ability to walk on water. The material, made from nanocellulose aerogel, can absorb huge amounts of oil and float on its surface, making it potentially useful for cleaning up oil spills.
Researchers at Northwestern University have developed a new method for creating scaffolds that are more flexible and less time-intensive than current technology. The process uses ceramic nanoparticles and elastic polymers to create highly interconnected pores that do not require the use of salt.
Scientists have developed a new smart polymer that breaks apart into small pieces in response to harmless levels of irradiation, paving the way for safe medical applications of tissue-penetrating light. The material has potential for use in diagnosing diseases and engineering new human tissues in the lab.
Tufts University researcher Catherine Kuo is developing living tissue in the lab to study factors contributing to birth defects. She plans to engineer normal and abnormal tissues to investigate the impact of muscle movement on embryonic development.
Researchers used computer-aided design to create accurate moulds and patient-specific physical scaffolds for breast tissue reconstruction. This technology holds promise for reducing scars, blood loss, and anaesthesia time, while improving surgical outcomes.
Professor Ali Khademhosseini, a leading expert in biomedical microdevices and biomaterials, will join the University of Texas at Austin's Department of Biomedical Engineering as a Donald D. Harrington Fellow. He aims to develop tissue-engineered organs and control cell behavior using novel, modular approaches.
Three Virginia Tech researchers, T.M. Murali, Padma Rajagopalan, and Rich Helm, are developing innovative solutions to study inter-cellular signaling in complex environments. They aim to provide a comprehensive picture of how cells communicate to maintain their phenotypes and optimize functions.
A new biomaterial more closely mimics native human tissue, exhibiting negative Poisson's ratio and maintaining its shape when stretched. The breakthrough enables the creation of biocompatible tissue patches for repairing damaged heart walls, blood vessels, and skin.