Articles tagged with Tissue Engineering
A 30-year-old Colombian mother received a tissue-engineered trachea in 2008, and five years later, she continues to enjoy a good quality of life without immunological complications or rejection. Regular testing reveals retained lung function and no scarring, although some symptoms remain monitored through bronchoscopies.
Researchers at Tel Aviv University have developed spring-like fibers to engineer cardiac tissue that can pump more like the real thing. The new fibers show improved elasticity and contraction force compared to straight fibers, holding promise for repairing damaged heart tissue.
Manuela E. Gomes, a Portuguese researcher, has received the 2013 TERMIS-EU Young Scientist Award for her contributions to tissue engineering and regenerative medicine. Her research focuses on bone and cartilage tissue engineering strategies, including scaffold materials, stem cells, and dynamic cell culturing systems.
Researchers discovered that low levels of a toxic protein may cause more harm than high levels in neurodegenerative diseases such as Alzheimer's. Short protein threads formed at low levels can lead to disease progression, whereas longer filaments are thought to be protective.
A novel thermo-sensitive injectable hydrogel engineered with gene modified bone marrow mesenchymal stromal cells (BMSCs) successfully repairs articular cartilage defects in rabbits. The study demonstrates the potential of tissue engineering combined with gene therapy for managing defective articular cartilage.
Researchers have made significant progress in engineering blue-green algae to produce nanocellulose, a 'wonder material' with great strength and potential applications in biofuels, biomaterials, and more. The team successfully engineered the algae to produce fully functional nanocellulose.
Scientists at the University of Granada have found that only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes. The researchers identified Wharton's jelly stem cells (HWJSC) as the most suitable subgroup, which can develop into several types of tissue and modulate immune responses.
Harvard scientists developed a method to grow 'cyborg' tissues by embedding nanoscale wires into engineered human tissues. They successfully seeded the networks with cells and encouraged them to grow in 3D cultures, enabling real-time monitoring and control of living systems.
A multi-institutional research team has developed a method for embedding networks of biocompatible nanoscale wires within engineered tissues. This allows direct tissue sensing and potentially stimulation, which could lead to the development of engineered tissues that incorporate capabilities for monitoring and stimulation.
University of Texas Medical Branch at Galveston researchers have been awarded a $1.25 million NIH grant to develop lab-grown lung tissue models for biomedical studies. These models could provide significant advantages over animal models, including reduced costs and the ability to study human responses more accurately.
Harvard University researchers have successfully created an artificial jellyfish using a silicone polymer and heart muscle cells. The Medusoid, as it's called, is capable of swimming and reproducing complex behaviors seen in biological jellyfish.
The tissue engineering and stem cell industries have experienced significant growth, with over half of companies generating revenue, up from 21% four years ago. Commercial products and services are driving the increase, with $3.5 billion in sales revenues and industry spending approaching $3.6 billion.
Researchers developed a new method to create 3D pancreatic beta-cell clusters that live longer and secrete more insulin than single cells. This breakthrough advances the study of pancreatic diseases like diabetes and enables testing of novel therapies.
New cell printing technology enables precise pattern formation of human cells, paving the way for advancement in tissue engineering and regeneration. Researchers demonstrated the use of acoustic droplet ejection followed by aqueous two-phase exclusion patterning to control cell placement.
Scientists have created a new buoyant material inspired by the water strider's ability to walk on water. The material, made from nanocellulose aerogel, can absorb huge amounts of oil and float on its surface, making it potentially useful for cleaning up oil spills.
Researchers at Northwestern University have developed a new method for creating scaffolds that are more flexible and less time-intensive than current technology. The process uses ceramic nanoparticles and elastic polymers to create highly interconnected pores that do not require the use of salt.
Scientists have developed a new smart polymer that breaks apart into small pieces in response to harmless levels of irradiation, paving the way for safe medical applications of tissue-penetrating light. The material has potential for use in diagnosing diseases and engineering new human tissues in the lab.
Tufts University researcher Catherine Kuo is developing living tissue in the lab to study factors contributing to birth defects. She plans to engineer normal and abnormal tissues to investigate the impact of muscle movement on embryonic development.
Researchers used computer-aided design to create accurate moulds and patient-specific physical scaffolds for breast tissue reconstruction. This technology holds promise for reducing scars, blood loss, and anaesthesia time, while improving surgical outcomes.
Professor Ali Khademhosseini, a leading expert in biomedical microdevices and biomaterials, will join the University of Texas at Austin's Department of Biomedical Engineering as a Donald D. Harrington Fellow. He aims to develop tissue-engineered organs and control cell behavior using novel, modular approaches.
Three Virginia Tech researchers, T.M. Murali, Padma Rajagopalan, and Rich Helm, are developing innovative solutions to study inter-cellular signaling in complex environments. They aim to provide a comprehensive picture of how cells communicate to maintain their phenotypes and optimize functions.
A new biomaterial more closely mimics native human tissue, exhibiting negative Poisson's ratio and maintaining its shape when stretched. The breakthrough enables the creation of biocompatible tissue patches for repairing damaged heart walls, blood vessels, and skin.
A new system allows for the measurement of power that cells employ to assemble into three-dimensional tissue. The research helps engineers evaluate how quickly cell types will combine into desired structures.
Researchers at Wake Forest University Baptist Medical Center successfully implanted laboratory-grown urethras in five boys, showing functional results throughout a six-year follow-up period. The engineered tissue replaced damaged segments of the urinary tube, providing an alternative to traditional tissue grafts with high failure rates.
Robert Langer will receive the Founders Award for his contributions to drug delivery and tissue engineering, while Anita Jones will receive the Arthur M. Bueche Award for leadership in science and technology policy. The awards recognize outstanding achievements that have benefited society.
Researchers from the University of Texas Medical Branch at Galveston have successfully grown new lung tissue using embryonic stem cells and decellularized rat lungs. The breakthrough, published in Tissue Engineering Part A, paves the way for potential applications in treating severe lung disorders such as cystic fibrosis.
Researchers develop micromasonry technique to assemble artificial tissues by encapsulating living cells in cubes and arranging them in 3-D structures. The method holds potential for building artificial tissue or medical devices with controlled microarchitecture.
Researchers use tissue engineering to create healthy organs and neuronal circuits, enabling live imaging of transplanted tissues and neural activity. The protocols provide methods for monitoring tissue perfusion, cell survival, and interaction/integration, allowing for improved culturing and implantation techniques.
Researchers at the University of Cincinnati are receiving a $3.75 million grant to study tendon development and create better repairs after injury using adult stem cells. The goal is to introduce signals that mimic normal tendon development during repair, leading to more effective soft tissue repairs.
Researchers created microchannels mimicking natural vasculatures using fractal patterns. The findings detail the construction of elaborate networks capable of supporting fluid transport, addressing a critical need in tissue engineering.
Researchers at Tufts University have created skin-like tissues using human embryonic stem cells, which can be used to treat oral and skin conditions. The breakthrough uses three-dimensional tissue engineering techniques to mimic the growth environment of human skin.
Kristen Billiar, a WPI biomedical engineering professor, has been awarded a Fulbright Scholarship to work on nanoscale scaffolds for tissue engineering at the National University of Ireland Galway. He aims to develop novel techniques to probe relationships between scaffold structure and mechanical functioning.
A pioneering study has successfully implanted autologous tissue-engineered vascular grafts in dialysis patients, with a majority of the grafts functioning for six to 20 months after implantation. The novel approach uses cells harvested from the patient's own skin to create the grafts without synthetic scaffolds or biomaterials.
Researchers at Brown University have successfully grown and assembled living microtissues into complex three-dimensional structures, advancing tissue engineering. The breakthrough could eventually reduce the need for certain kinds of animal research, with implications for basic cell biology, drug discovery, and tissue research.
Eben Alsberg, a biomedical engineering professor at Case Western Reserve University, has received the Ellison Medical Foundation New Scholar in Aging award. The award provides funding for his project to develop novel microenvironmental technology to rescue chondrogenic potential of mesenchymal stem cells from aged individuals.
Researchers at Rice and UT-Houston will lead a $2 million DOD-funded project to develop new tissue engineering technologies and novel reconstructive surgical techniques for facial reconstruction. The goal is to quickly grow large volumes of bone tissue to aid wounded soldiers.
The study outlines strategic directions in tissue engineering, focusing on angiogenic control, stem cell science, and molecular/systems biology to provide engineered tissues with adequate blood supply and integrate knowledge at the cellular and molecular level.
Researchers at MIT have developed a method to create three-dimensional microparticles using ultraviolet light, offering unprecedented control over size, shape, and texture. The particles can be designed with specific chemical properties, such as porosity, making them suitable for use in medical diagnostics and tissue engineering.
Cornell engineers develop gel scaffold that can nourish growing tissues, supplying oxygen and nutrients. The system mimics a vascular system at the cellular scale, allowing for fine-tuning of biochemical environments and desired tissue outcomes.
Xinqiao Jia is awarded a National Science Foundation Faculty Early Career Development Award for her work on developing strong, yet soft and flexible biomaterials for engineering damaged tissues. Her goal is to create hybrid materials that can respond rapidly and reversibly to mechanical forces.
Researchers successfully engineered human cartilage using tissue engineering methods, demonstrating potential for therapeutic applications. The study also found that osteogenic protein-1 enhances cartilage production when added to chondrocytes on scaffolds.
Dr. David Mooney is recognized for his groundbreaking work on tissue engineering and tissue regeneration, including blood vessel and bone regeneration. He will receive the IADR Isaac Schour Memorial Award, a prestigious honor acknowledging outstanding scientific contributions in the field.
Researchers at the University of Bristol successfully regenerated cartilage in injured knees using bioengineered tissue implants. The study showed that engineered cartilage tissue can grow and mature even in knees affected by osteoarthritis, offering a promising approach to treating joint damage.
Dental stem cells have been characterized for their potential to differentiate into various tooth tissue types. The study aims to define the molecular and differentiation profiles of these cells, enabling ongoing tooth tissue engineering efforts.
Researchers developed engineered tissue that can conduct electricity, potentially replacing pacemakers in children with heart block. The tissue was tested in rats and shown to integrate with surrounding heart tissue, establishing an electrical conduction pathway.
Researchers have made significant breakthroughs in developing biohybrid lung devices, regenerative potential of stem cells, biomechanical training of tissue constructs, and artificial esophagus using extracellular matrix scaffolds. These advancements aim to restore function of damaged or diseased tissues and organs.
Researchers at Rice University have developed a self-assembly method to grow dime-sized disks of cartilage with properties approaching native tissue. The technique uses only donor cells, eliminating rejection risks, and has been refined to produce virtually identical cartilage in terms of mechanical and biochemical makeup.
Researchers successfully produced blood vessels within heart muscle tissue, showing significant improvement in heart function. The tissue-engineered construct remained viable even after three weeks of implantation, maintaining cardiac specific function.
Researchers created a simplified version of cardiac tissue using cells from neonatal rats, mimicking normal heart tissue. The study found that pace-setting pulses successfully halted the abnormal rhythm 80% of the time, but in 20% of cases, it worsened the condition.
Researchers at Virginia Tech have developed a new bone tissue engineering material using amorphous calcium phosphates, which they believe could lead to faster and higher quality bone formation. The team's work, in collaboration with the American Dental Association, is currently in press for several scientific journals.
Researchers have developed a new tissue-engineered vessel made from the patient's own cells, which can replace synthetic grafts used in coronary bypass surgeries. The first human trial showed promising results, with no failures noted during the first five months of use.
The University of Liverpool is leading a major €17 million European tissue engineering project, funded by the European Commission. The project aims to develop cost-effective methods for generating precise tissue types specific to individual patients.
Researchers have developed a bank of fetal skin cells that can provide burned patients with high-quality skin substitutes, closing wounds in just over two weeks. The technique has great potential for tissue engineering and could simplify the surgical process.
Researchers at Vanderbilt University have created a new approach to tissue engineering that allows for the growth of predictable volumes of bone on demand. This method involves creating a 'bioreactor' space under the periosteum, a thin outer layer covering long bones, and filling it with a gel containing calcium to stimulate bone growth.
Researchers are exploring new technologies to regenerate bone, enhance ligament healing, produce tissue-engineered cartilage and improve bone healing with stem cells derived from muscle. These advances hold promise for treating devastating congenital or traumatic problems and preventing degenerative processes in the aging population.
Tissue engineering aims to regenerate human tissue through artificial means, mimicking the body's natural processes. Researchers at U-M School of Dentistry are working on combining therapies to improve tissue engineering outcomes, such as using parathyroid hormone and bone morphogenetic proteins.
Jeffrey A. Hubbell will receive the Elmer Gaden Award, a $1000 prize, and an acknowledgement in an upcoming journal issue. The award lecture will be held on March 15, 2005, at the American Chemical Society's National Meeting in San Diego.
Mikos has developed extensive expertise in fabricating synthetic materials with tailored chemistries for specific tissue-engineered repair of orthopaedic injuries. His laboratory has created novel materials based on fumaric acid, non-toxic to surrounding cells and tissues.
The Center will focus on designing biodegradable tissue engineering scaffolds and novel bioreactors to optimize stem cell responses toward new tissue formation. It will also host collaborations with other laboratories to enhance core projects, such as tissue engineering of human ligaments using transfected adult stem cells.
Dr. Anseth's team has developed an injectable scaffold to regenerate cartilaginous tissue using light-activated chemistries, with potential applications in treating Parkinson's disease by injecting stem cells into human brains.