Articles tagged with Tissue Engineering
Researchers successfully recreated lung cancer patient's internal environment using hydrogel and 3D bioprinting, preserving specific lung cancer subtype and genetic mutation characteristics. The study enables precise drug evaluation and personalized treatment options for lung cancer patients with underlying diseases.
A miniature human heart model, approximately half a grain of rice in size, has been developed to transform drug testing and cardiovascular research. This self-paced, multi-chambered model provides real-time measurements of essential parameters, enabling unprecedented insights into heart function and diseases.
University of Melbourne researchers developed a novel approach to 'tissue engineering' blood vessels by combining multiple materials and fabrication technologies. The method creates blood vessels with complex geometries like native blood vessels, offering a transformative solution for cardiovascular disease.
Researchers at UC San Diego report new direct evidence of atrophy and fibrosis in pelvic floor muscles of women with symptoms of pelvic organ prolapse. They also showed that an acellular injectable skeletal muscle extracellular matrix hydrogel reduces the negative impact of simulated birth injury on rat pelvic floor muscles.
A University College Dublin researcher has received a European Research Council Proof of Concept grant to investigate the disruptive power of macromolecular crowding in cell culture systems. The project aims to develop novel approaches for regenerative medicine by accelerating tissue development and improving therapeutic potential.
Researchers at Harvard developed a fiber-infused ink that allows 3D-printed heart muscle cells to align and contract like human heart cells, enabling the creation of functional heart ventricles. The innovation can be used to build life-like heart tissues with thicker muscle walls, paving the way for regenerative therapeutics.
A team from Tokyo Medical and Dental University has developed a technique to improve bone regeneration over large areas in rats, using vascular endothelial growth factor (VEGF) and Runx2. The combination of these two RNAs led to better regenerative responses in bone cells than each RNA alone.
The PULSE project combines magnetic and acoustic levitation to bioprint highly sophisticated organoids that closely mimic human organs. These in vitro heart models will provide invaluable insights into cardiac physiology and pathology, enabling the development of preventive and therapeutic solutions.
Researchers from Tokyo Medical and Dental University successfully generated functional parathyroid glands from mouse embryonic stem cells using blastocyst complementation. This breakthrough study demonstrates the potential for regenerating organs in vivo and provides a new treatment option for hypoparathyroidism.
Researchers developed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering, demonstrating potential for clinical applications. The scaffolds can reconstruct desired tissue EM through non-invasive ultrasonic stimulation, promoting cell adhesion and osteogenic differentiation.
A novel biomaterials-based approach enhances adoptive T cell therapy with cancer vaccine technology, providing strong and long-lasting effects against solid tumors. In mice carrying melanomas, SIVET enables fast tumor shrinking and long-term protection.
Researchers create a three-dimensional epithelial model that reproduces the human lip area, allowing for evaluation of cosmetic ingredients and products. The model's structure and differentiation mode are similar to those of actual human lip tissue.
The technique has the potential to overcome major shortcomings associated with conventional bioprinting, allowing real-time wound treatment and immediate anastomosis with native tissue. However, challenges remain, including integration with surrounding tissues and limited access to defect sites in articular joints.
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
Recent innovations in volumetric bioprinting by UMC Utrecht researchers enable faster and more clinically relevant printing of living tissues. By controlling chemical properties, the team creates smart materials that guide cell behavior and development, mimicking native biochemical environments.
Scientists have developed an innovative platform using engineered human tissue to study how pathogens carried by mosquitoes impact and infect human cells. This breakthrough holds promise for studying other disease vectors like ticks, which spread Lyme disease.
Researchers at the University Medical Center Utrecht combined volumetric bioprinting and melt electrowriting to create functional blood vessels. The technique allowed for the creation of tubes, forked vessels, and even venous valves with unidirectional flow, paving the way for further development into a fully functional blood vessel.
Researchers at UMC Utrecht successfully merged two printing techniques to create functional tissues made from stem cells. Granular biogels enable high cell density, survival, and specialization, surpassing solid gels. This breakthrough boosts tissue functionality and opens up opportunities for regenerative medicine.
A University of Virginia-led study challenges traditional understanding of associative polymers' behavior, revealing that reversible bonds slow down polymer movement without creating a rubbery network. This discovery has implications for materials used in sustainability, health, and engineering applications.
Biomedical engineers at UTS have developed an intervertebral disc-on-a-chip, a precision-engineered toolbox for low back pain studies. The device simulates the complex mechanobiology of native tissue, enabling accurate evaluation of experimental methods for treatment or regeneration.
A new method for producing biocompatible microfibres with controlled size and shape has been developed at Graz University of Technology, significantly accelerating production and reducing costs. This breakthrough enables the potential for accelerated production of autologous skin and organs, which could be a game-changer for burn victi...
Researchers at POSTECH have developed a bioink using alginate from algae and visible light, resulting in enhanced cell viability and printing resolution. This innovation could lead to the creation of artificial organs and tissues, as well as cultivated meat with lower environmental impact.
Scientists adapted volumetric bioprinting to create three-dimensional, biologically functional areas within printed gels. The technique enables the infusion of biomolecules and growth factors into gelatin structures, creating a chemical map that guides cells to develop or specialize accordingly.
A multi-institutional team of experts is studying how to use focused ultrasound to create a temporary gateway through the blood-brain barrier to deliver cancer medicine. Researchers aim to develop a personalized medicine approach in which they can test drugs on patient tumors and predict treatment effectiveness.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
The PRISM-LT project aims to create an adaptable platform for 3D bioprinting of living tissue with dynamic functionalities and predictable shapes, using a novel tunable bioink that fosters a symbiotic relationship between stem cells and microorganisms.
Researchers at Linköping University developed a nanocellulose wound dressing that reveals early signs of infection through pH monitoring. This technology can lead to more efficient care and reduce unnecessary antibiotic use.
Scientists have developed a method to activate protein functions using brief flashes of light, enabling precise control over when and where chemical reactions occur. This technology has potential uses in tissue engineering, regenerative medicine, and understanding biological processes.
Scientists discover carbonated water's impact on low-methoxy pectin hydrogel formation and properties. The study shows that CO2 from carbonated water increases mechanical strength and gelation rate of hydrogels.
Researchers at the University of Bath have successfully created antimicrobial ferroelectric composite materials using a novel 3D printing process. These materials can eradicate E coli bacteria within 15 minutes, with potential applications in heart valves, stents, and bone implants.
Researchers created a three-dimensional structure that mimics bone and houses osteosarcoma cells beside immune cells, finding increased inflammation reduces chemotherapy effectiveness. The study highlights the importance of the tumor microenvironment in disease progression and treatment.
Researchers at NIST have developed a real-time technique to noninvasively count the number of live cells in a 3D artificial scaffold, meeting an unmet need in tissue engineering. The method uses optical coherence tomography and is label-free, reducing time and cost compared to earlier methods.
Scientists create hybrid composite scaffolds with aligned nanofibrous architectures to improve cell seeding efficiency, proliferation rates, and morphogenesis. The findings have potential applications in tissue repairing and regenerative medicine.
Researchers at University of Technology Sydney have successfully created personalized 'bio-inks' from patients' own stem cells, which are then used to 3D-print cardiac tissues to repair areas of dead tissue. This technology shows promise in treating heart failure and may reduce the need for expensive and traumatic heart transplants.
A new 3D-printed scaffold made of a dissolvable polymer is shown to create nipples that maintain long-lasting projection, unlike previous reconstruction approaches. The device has the potential to improve breast reconstruction results and could be available for women undergoing mastectomy in the near future.
Alejandro Sánchez Alvarado is awarded the Vilcek Prize in Biomedical Science for his groundbreaking work on regeneration. His research has significant implications for understanding cellular and organismal regeneration, with potential for further breakthroughs.
Researchers at UC San Diego develop new bioink with iodixanol, reducing light scattering and enabling high cell density printing. The technique creates functional human-like tissues with improved resolution and perfusion systems for long-term culture.
A research team at Chinese Academy of Sciences creates a spinal cord-like implant with covalent conjugation between biomaterials and cells, promoting cell retention and neural regeneration in rats after spinal cord injury. The study's findings have potential implications for human spinal cord tissue engineering therapy.
Researchers at Rice University have developed a self-assembling peptide ink that enables the 3D printing of complex structures with cells, which can then be used to grow mature tissue in a petri dish. The ink allows for control over cell behavior using structural and chemical complexity.
A Korean joint research team has developed a new tissue adhesive that restores damaged corneas by filling them and exposing them to light, potentially treating cornea ulcers without surgical interventions. The new sealant integrates well with adjacent tissues and promotes scar-free corneal tissue reconstruction.
Researchers at Aarhus University are developing a novel treatment for multiple sclerosis by spinning artificial nerve fibers using electro-spun fibres. The goal is to restore nerve impulses quickly, as the myelin sheath deteriorates with age.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
The NSF is funding projects that utilize the International Space Station (ISS) National Laboratory to advance tissue engineering and mechanobiology research. This solicitation aims to further drug discovery and therapeutic development through space-based research, with potential impacts on regenerative medicine and disease diagnosis.
The study successfully synthesised hybrid biomaterials using nanoparticles and showed excellent stem cell attachment and growth on the scaffolds. The material also promoted axonal cell migration towards the site of spinal cord injury, reducing scarring and inflammation. This research holds promise for treating spinal cord injuries.
Researchers from Yokohama National University successfully generated hair follicles in cultures using organoid cultures. The study demonstrates the potential of hair follicle organoids for understanding hair follicle development and regeneration, as well as evaluating drugs for treating hair loss disorders.
Researchers aim to develop scalable, modular manufacturing platform for growing new tissues from component parts, accelerating their fabrication and use. The goal is to assemble functional constructs that restore or improve damaged tissues or whole organs.
Researchers discuss benefits of using humanoid musculoskeletal robots and soft robotic systems as bioreactor platforms for producing clinically useful tendon constructs. These systems provide physiologically relevant mechanical stimulation, overcoming the translational gap in current conventional bioreactors.
Researchers at POSTECH have developed a method to engineer organs at scale using bioprinting, overcoming previous limitations of small tissue size and functional complexity. This innovation holds promise for personalized treatment of patients with the potential to create more realistic engineered organs.
Researchers from UMass Amherst have created a tiny sensor that can simultaneously measure electrical and mechanical cellular responses in cardiac tissue. This breakthrough device has the potential to lead-edge applications in cardiac-disease experiments and improve health monitoring for cardiac disease studies.
Researchers at Karolinska Institutet have developed a method to create a three-dimensional gel from spider silk proteins that can be designed to deliver functional proteins. The gel has the potential to revolutionize regenerative medicine, enabling controlled drug release and tissue engineering applications.
University of Toronto researchers develop a lab-grown model of the human left heart ventricle made with living heart cells. The bioartificial tissue construct beats strongly enough to pump fluid inside a bioreactor and offers new possibilities for studying heart diseases and testing potential therapies. Future work aims to increase the...
Researchers at TU Wien develop a method to guide individual cells with laser precision, enabling reproducible production of artificial tissue and testing new drugs without animal testing. The technique involves adding special molecules to hydrogel surrounding cells, which become softer and more permeable when activated by a laser beam.
Scientists from Tokyo Medical and Dental University uncover the reason behind titanium implants' excellent biocompatibility, allowing patients to generate less immune response. This breakthrough may lead to safer and less expensive implants for hip replacements and dental procedures.
Researchers created human mini-kidneys that mimic diabetic kidneys, finding increased susceptibility to SARS-CoV-2 infection and a critical role for the ACE2 receptor. The study provides new insights into the link between diabetes and COVID-19 disease.
Researchers from Columbia University have developed a plug-and-play multi-organ chip, customized to the patient, consisting of engineered human heart, bone, liver, and skin linked by vascular flow. The model allows for long-term studies and can be optimized for personalized therapy optimization in cancer and systemic diseases.
A team of researchers from Osaka University and Kyoto University developed a stem cell-based biomaterial, hiPS-Cart, to treat IVD degeneration and prevent further deterioration. The biomaterial was able to survive and maintain its functionality in lab rats with NP removal, reversing IVF and vertebral bone degeneration.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Researchers at TU Wien have developed a new approach to produce artificial tissue using micro-scaffolds with a diameter of less than a third of a millimetre. These scaffolds can accommodate thousands of cells and enable high cell density and control over mechanical properties.
Researchers from the Wyss Institute discovered that applying mechanical forces mimicking breathing motions suppresses influenza virus replication and activates protective innate immune responses. The Human Lung Chip was used to model these responses, leading to repurposed drugs for treating inflammatory lung diseases.
Researchers at the University of Illinois Chicago have developed a new cell-laden bioink that enables the production of complex, shape-changing bioconstructs. These 4D constructs have the potential to mimic the body's natural developmental processes and could lead to advances in tissue engineering.