Articles tagged with Tissue Engineering
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University of Toronto researchers develop a lab-grown model of the human left heart ventricle made with living heart cells. The bioartificial tissue construct beats strongly enough to pump fluid inside a bioreactor and offers new possibilities for studying heart diseases and testing potential therapies. Future work aims to increase the...
Researchers at TU Wien develop a method to guide individual cells with laser precision, enabling reproducible production of artificial tissue and testing new drugs without animal testing. The technique involves adding special molecules to hydrogel surrounding cells, which become softer and more permeable when activated by a laser beam.
Scientists from Tokyo Medical and Dental University uncover the reason behind titanium implants' excellent biocompatibility, allowing patients to generate less immune response. This breakthrough may lead to safer and less expensive implants for hip replacements and dental procedures.
Researchers created human mini-kidneys that mimic diabetic kidneys, finding increased susceptibility to SARS-CoV-2 infection and a critical role for the ACE2 receptor. The study provides new insights into the link between diabetes and COVID-19 disease.
Researchers from Columbia University have developed a plug-and-play multi-organ chip, customized to the patient, consisting of engineered human heart, bone, liver, and skin linked by vascular flow. The model allows for long-term studies and can be optimized for personalized therapy optimization in cancer and systemic diseases.
A team of researchers from Osaka University and Kyoto University developed a stem cell-based biomaterial, hiPS-Cart, to treat IVD degeneration and prevent further deterioration. The biomaterial was able to survive and maintain its functionality in lab rats with NP removal, reversing IVF and vertebral bone degeneration.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Researchers at TU Wien have developed a new approach to produce artificial tissue using micro-scaffolds with a diameter of less than a third of a millimetre. These scaffolds can accommodate thousands of cells and enable high cell density and control over mechanical properties.
Researchers from the Wyss Institute discovered that applying mechanical forces mimicking breathing motions suppresses influenza virus replication and activates protective innate immune responses. The Human Lung Chip was used to model these responses, leading to repurposed drugs for treating inflammatory lung diseases.
Researchers at the University of Illinois Chicago have developed a new cell-laden bioink that enables the production of complex, shape-changing bioconstructs. These 4D constructs have the potential to mimic the body's natural developmental processes and could lead to advances in tissue engineering.
Researchers have identified a previously unknown bacterial enzyme that can produce a new type of biodegradable polysaccharide called acholetin. Acholetin has wide-ranging potential as a biocompatible, biodegradable material for biomedical applications.
Scientists at Tel Aviv University have created two-dimensional polymer microfiber networks that exhibit shape memory properties. These networks can be controlled by temperature-induced changes, allowing for morphing materials with microscale resolutions.
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
Scientists at Tokyo Medical and Dental University developed artificial tendons using human stem cells, mimicking natural tendon properties. The resulting tissue exhibited similar mechanical and biological properties to normal tendons, making it an attractive strategy for clinical application in tendon injuries.
Researchers at RMIT University used high-frequency sound waves to turn stem cells into bone cells, overcoming challenges in mass production and pain associated with extraction. The innovative treatment is faster, simpler, and more efficient than existing methods.
The BRIGHTER project develops a new 3D bioprinting technology that creates complex and accurate human tissues, reducing the need for animal models. The technology uses light-sheet lithography to fabricate human skin and other tissues with high resolution and accuracy.
Researchers developed a fully autonomous biohybrid fish from human stem-cell derived cardiac muscle cells that recreates the muscle contractions of a pumping heart. The device has two layers of muscle cells that work together to propel the fish for over 100 days.
Scientists from Tokyo Medical and Dental University have developed a protocol to transplant 3D cellular structures called organoids into the colon to repair damaged intestinal tissue. This approach shows promise as a quick, reproducible, and minimally invasive method for treating ulcerative colitis.
A multidisciplinary research team from the University of Pittsburgh seeks to improve vascular graft integration by developing fully biodegradable tissue-engineered vascular grafts. The goal is to keep compliance-matched as it degrades and remodels, reducing long-term graft failure rates.
Researchers at Brown University have developed a new laboratory test model to investigate fibrosis treatments without the use of animals. The model uses human cells and replicates not only the structure of human tissue but also its mechanics, enabling scientists to study the underlying mechanisms of fibrosis and test potential treatments.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
A team from Tokyo Medical & Dental University has created a jigsaw-shaped peptide that functions as an extracellular matrix for injured tissue regeneration. The peptide's ability to incorporate and release growth factors stimulates cell growth and vascular formation, showing promise in regenerating tissues.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
A new study from Princeton University shows how the brown anole lizard solves breathing problems with crude yet effective lobes covered in bulbous protuberances. The lizard's lung development is achieved through a physical mechanism that allows for rapid growth and gas exchange.
Scientists from Tokyo Medical and Dental University create polyrotaxane-based biomaterials that improve epithelial cell-cell adhesion, enabling the repair of damaged tissues. The study suggests a potential application in clinical dentistry for treating periodontal disease.
Researchers discovered that mechanical forces guide cell development, influencing gene expression and potentially leading to pathologies like heart disease. The findings could inspire advances in engineering authentic artificial tissue for medical applications.
Researchers at Technion and Sheba Medical Center have developed a new technology for fabricating custom-made ear implants for microtia patients. The biodegradable auricle scaffold is 3D-printed using the patient's own cells, reducing the risk of complications and discomfort associated with traditional methods.
Researchers at Lehigh University are working on a project funded by the Good Food Institute grant to adapt human tissue engineering techniques for growing meat in the lab. The team is developing a scaffold for meat cells to grow on and using electrochemistry, nanomaterial design, and liposomal delivery vehicles to promote fibrous growth.
A team of researchers led by Guy Genin and Stavros Thomopoulos found a previously unknown fibrous architecture in the shoulder joint, revealing new features of the attachment system. The discovery sheds light on how the rotator cuff functions and why repairs fail frequently.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
Researchers aim to replicate natural tendon development using embryonic chicken and mouse models, with a focus on mechanical stimulation and nanoparticle design.
A team of Montreal researchers has created a new method of bioprinting adult neuron cells using Laser-Induced Side Transfer (LIST) technology. The technique successfully prints sensory neurons, which are vital for the peripheral nervous system, and shows promise for drug discovery, disease modeling, and implant fabrication.
Researchers will explore ways to regenerate damaged salivary glands and understand vocal fold scarring, aiming to develop new treatment options for head and neck cancer patients. The project includes creating a vocal-fold-on-a-chip model with embedded sensor technology to monitor tissue development in real-time.
Caltech researchers have developed a technique to build embryo-like structures from human stem cells, opening up new possibilities for studying early human development. The technology can generate large quantities of these structures without the need for donated embryos.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
Researchers from the University of Basel have found that nasal cartilage cells can withstand chronic inflammatory conditions and counteract inflammation in osteoarthritis. The approach involves using engineered cartilage tissue to repair or replace damaged joints, offering a promising alternative to joint prostheses.
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.
Researchers developed a pollen-based hybrid ink that can be used to fabricate parts useful for tissue engineering, toxicity testing and drug delivery. The ink is biocompatible, flexible and low in cost, allowing for the creation of customized flexible membranes tailored to human skin contours.
Researchers have developed a special polymer to coat blood vessels on transplanted organs, reducing rejection rates in mice by substantially diminishing immune system response. The breakthrough has the potential to eliminate the need for drugs that prevent organ rejection and improve transplant outcomes.
Rice University bioengineers are developing an insulin-producing implant to regulate blood glucose levels in Type 1 diabetics. The implant uses human stem cells and 3D printing to mimic the natural behavior of the pancreas, with the goal of achieving consistent target blood glucose levels.
Alastair Sloan, Head of School at the Melbourne Dental School, has received the 2021 IADR Isaac Schour Memorial Award for his significant contributions to tissue engineering and dental biology. He was recognized for his work on regeneration of mineralized tissues and behavior of dental pulp stem cells.
Researchers at Emory University developed a shape-shifting nanomaterial made of synthetic collagen that can be triggered to change its form from flat sheets to tubes and back again. The material has biomedical applications such as controlled-release drug delivery and tissue engineering.
Researchers developed a multidimensional model of trophoblast motility using a functionalized gelatin hydrogel. The study revealed that EGF and TGF-beta1 play critical roles in modulating trophoblast motility, providing insights into implantation mechanisms during normal and complex pregnancies.
Researchers developed an algae-based 3D bioprinting method to incorporate vascular patterns within engineered tissues and provide a sustainable source of oxygen for human cells. The approach showed promise for applications in disease modeling, drug development, regenerative and personalized medicine.
A University of Sydney team has developed a plasma technology to attach hydrogels to polymeric materials, allowing for better interaction with surrounding tissue. The technology has shown promising results in tests using biomolecules found in the body.
Researchers at the University of Nevada, Reno have engineered thale cress to improve water-use efficiency and salinity tolerance, a trait that can be applied to other plants to address future food shortages and climate change impacts.
A new combination of 3D printing and acoustic droplet ejection technology enables precise control over growth factor presentation, promoting osteogenic differentiation in C2C12 mouse myoblast cells. This technique has vast potential for various tissue types beyond bone engineering.
Researchers created an electrospun fiber blending protein and polymer, demonstrating gradual protein release. The study showcases the versatility of blended mats for biomedical applications like burn dressings, drug delivery, and tissue engineering.
Researchers develop combined technique to restore damaged intervertebral discs, improving hydration and structural integrity of the nucleus pulposus. The method also repairs damaged annulus fibrosus tissue, suggesting a potential strategy for improving outcomes in discectomy patients.
Scientists are developing novel tissue engineering techniques using everyday materials such as ice, eggshells, and spinach. These biomaterials are more functional, sustainable, and cost-effective than traditional methods.
A study directly compares chondrogenic induction by hydrogels containing MSCs as either single cell suspensions or 100-500-cell micropellets. The results show that micropellet-encapsulated MSCs outperform single cells in cartilage regeneration, providing guidance for future cartilage engineering efforts.
North Carolina State University researchers have created a technique called ultrasound-assisted biofabrication (UAB) to align living cells during the bioprinting process. This allows for the creation of tissues with characteristics similar to natural tissues, such as a knee meniscus with aligned cell structures.
A team of biomedical engineers has developed a stem cell cardiac patch made with tissue engineered with tiny blood vessels to mimic real heart muscle. The patch can connect to native vasculature, bringing nutrients and oxygen, making it potentially effective for treating myocardial infarction.
A new study reveals that pulsed electromagnetic fields (PEMFs) increase osteoblast precursor cell proliferation and induce osteogenic gene expression, but do not enhance calcium deposition. Careful selection of PEMF parameters is crucial for inducing a favorable effect.
Scientists developed a hybrid biosensor scaffold material based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. This allows visualization of cell growth and metabolism in engineered tissues by microscopy. The study was published in Acta Biomaterialia and has promising prospects for regenerative medicine.
Chondral defects are common, with slow self-healing properties of articular cartilage limiting treatment effectiveness. Cartilage tissue engineering offers new hope for patients, using various scaffold materials and preparation techniques to treat chondral defects.
Researchers highlight advancements in electrospinning for use in rotator cuff tissue engineering, focusing on improving nano-topographical properties and mechanical strengths. Human tissue is used to determine cyto-compatibility, but outcome measures vary across studies.
Researchers have created biomaterials that combine ordered and disordered segments to form a stable, porous scaffold that promotes cell growth and vascularization. The material's unique properties enable it to integrate into tissue with minimal inflammation and hold its volume well.
Researchers at Peter the Great St. Petersburg Polytechnic University create three-dimensional porous material made of collagen and chitosan to restore bone tissue after trauma or illness. The material stimulates natural tissue growth, eliminating the need for lifelong medication.
Researchers developed a cartilage matrix that mimics early stages of repair and provides necessary structural properties for bone-forming cells. The decellularized cartilage-based scaffold effectively directs chondrogenic differentiation and creates a fracture callus mimetic.