Articles tagged with Tissue Engineering
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers have created 'skin in a syringe' by mixing cells with gelatine beads, allowing for 3D printing of functional dermis. This technology could lead to new ways to heal burns and severe wounds with minimal scarring.
Scientists have developed a breakthrough method to grow human kidney organoids from tissue stem cells, mirroring fetal kidney development over months. The organoids can be used for research and testing of new treatments for kidney diseases.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
Researchers designed a hydrogel system using milk-derived extracellular vesicles as both bioactive cargo and structural building blocks, enabling tissue engineering and regenerative medicine applications. The yogurt EVs promote healing and tissue regeneration without additional chemical additives.
Researchers developed a new 3D tissue model to understand and treat fibrosis, a disease that causes scarring in organs like lungs and kidneys. The model replicates the complexities of real disease and preserves natural cell diversity.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
Researchers at RCSI University of Medicine and Health Sciences have developed a 3-D printed implant that delivers electrical stimulation to injured areas of the spinal cord, enhancing nerve cell growth. The study has shown promising results in lab experiments and may enable new medical devices for traumatic spinal cord injuries.
IBEC researchers develop new bioinks that incorporate extracellular matrix proteins, preserving biological function and allowing growth factors to be retained. The FACTORINK project aims to realise the potential of these bioinks for printing artificial tissues with multiphase models incorporating stem cells and the immune system.
GeniPhys has received FDA clearance for its self-assembling collagen scaffold, Collymer Self-Assembling Scaffold (SAS), which supports cellular infiltration and vascularization. The technology is indicated for various wound types and anchors a growing intellectual property portfolio with nearly 20 issued or pending patents.
A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
A new hydrogel-based platform has been developed to preserve live patient-derived tumor tissues in the lab, enabling more accurate testing of cancer treatments. The approach, which uses customizable bioengineered hydrogels, has been shown to retain key features of the original tumor environment.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
Recent studies have made significant progress in tissue engineering theory and technology, focusing on biomaterials, cells, and factors. Researchers have developed novel implant materials, improved artificial ligaments, and discovered small-molecule compounds in traditional Chinese medicine.
Researchers found that intercellular flow plays a major role in tissue response to deformation, affecting organs' adaptability to conditions like aging and cancer. The study's findings could inform the design of artificial tissues and organs.
Professor Garry Duffy joins RCSI with a unique combination of institutional knowledge and fresh leadership perspective, focusing on integrating excellence in health sciences education with innovative patient-centred research. He aims to build on the university's heritage by enhancing anatomical education and pioneering research in rege...
Researchers at the Institute of Industrial Science, The University of Tokyo, found that increasing levels of free amino acids in the culture medium can increase intracellular free amino acids and influence flavor compounds in cultured meat. Glutamic acid was the most prominent amino acid, while alanine was higher in conventional beef.
Researchers at Boise State University have developed a technique to use graphene foam to stimulate cells into forming cartilage. The study found that applying direct electrical stimulation strengthens the mechanical properties of cartilage and improves cell growth, paving the way for new treatments for osteoarthritis.
The University of Houston has launched a $3M Cancer Immunotherapy Biomarker Core to accelerate early diagnosis and treatment response in cancer. The core will offer comprehensive targeted proteomic cancer biomarker screens, enabling researchers to identify better biomarkers for cancer.
Researchers at TU Wien have developed a method to create artificial blood vessels using ultrashort laser pulses, enabling the creation of mini organ models with precise control and reproducibility. The technology has been successfully applied to liver tissue models, resulting in improved metabolic activity and adequate nutrient supply.
The new 3D-printed device, STOMP, enhances tissue-engineering methods by allowing for precise control over cell types and spatial arrangement. This enables scientists to model complex diseases and recreate natural habitats of cells, paving the way for advancements in biomedical research.
Antonios Mikos, a leading expert in biomaterials and tissue engineering, has been elected to the European Academy of Sciences. He is recognized for his groundbreaking work in regenerative medicine, controlled drug delivery, gene therapy, and disease modeling.
Researchers from Yokohama National University have developed a method to fabricate complex oriented tissues with multiple directionality using 3D printing. This technique utilizes flow to orient collagen fibers and cells, allowing for the creation of fine, micro-oriented structures in both horizontal and vertical directions.
Researchers developed collagen-based scaffolds that can integrate with a vascular and perfusion organ-on-a-chip reactor to form complete tissue engineering platforms. The team demonstrated the ability to create non-planar 3D networks in soft, organic material by printing helical vascular networks modeled after DNA structure.
Researchers at Carnegie Mellon University have developed a novel FRESH bioprinting technique that enables the creation of microphysiologic systems entirely out of collagen, cells, and other proteins. This advancement expands the capabilities of studying disease and building tissues for therapy, such as Type 1 diabetes.
Dr. Ali Khademhosseini, TIBI Director, receives the 2025 MRS Mid-Career Researcher Award for his groundbreaking contributions to biomaterials science and tissue engineering. His research has revolutionized engineered tissue constructs for drug discovery and regeneration.
Lower-intensity electrical pulses reshape the tumor environment, increasing blood vessel density and boosting lymphatic vessel growth. This may guide immune cells to the tumor, improving the body's natural ability to fight cancer.
MIT engineers have developed a way to grow artificial muscles that twitch and flex in multiple coordinated directions. This breakthrough allows for the creation of soft, wiggly robots with enhanced flexibility and range of motion.
Researchers have made significant progress in applying tissue engineering to spinal cord injury (SCI) repair. Biomaterials such as hydrogels and decellularized extracellular matrix promote nerve regeneration, while stem cells and exosomes enhance functional recovery.
Researchers have developed a method to repair complex knee injuries using cartilage implants made from nasal septum cells. The study shows that longer maturation periods of the implant lead to better clinical efficacy and tissue composition.
Researchers developed mini biohybrid rays using cardiomyocytes and rubber, demonstrating improved swimming efficiencies approximately two times greater than previous biomimetic designs. The application of machine-learning directed optimization enabled an efficient search for high-performance design configurations.
Researchers reviewed recent developments on functional scaffolds for bone tissue engineering, highlighting their potential for enhanced oxygen transport and cell differentiation. The study aims to inspire novel solutions for bone regeneration through the use of biocompatible and biodegradable materials with 3D printing techniques.
Researchers at Rice University have discovered a new method for customizing engineered living materials (ELMs) by altering protein matrices. The study revealed that small genetic changes can significantly impact the behavior of these materials, making them ideal for applications like tissue engineering and drug delivery.
Seoul National University researchers create bioink from Kombucha SCOBY nanocellulose, suitable for in vivo tissue engineering. The bioink can be precisely applied directly onto damaged tissues using a digital biopen, paving the way for more personalized and effective wound healing.
A global team of scientists has made a groundbreaking discovery of a new skeletal tissue called lipocartilage, composed of fat-filled cells that provide super-stable internal support. This unique tissue has immense potential for treating facial defects, birth injuries, and cartilage-related conditions.
Lehigh University bioengineering researcher Tomas Gonzalez-Fernandez is exploring how combining CRISPR with biomaterials can improve gene editing's safety and efficacy for therapeutic use. His NSF CAREER award-funded research aims to develop more targeted and controlled therapies for genetic diseases.
Researchers at University of California, Irvine have discovered a new type of skeletal tissue that offers great potential for advancing regenerative medicine and tissue engineering. The 'lipocartilage' tissue is uniquely packed with fat-filled cells called lipochondrocytes that provide super-stable internal support.
The Wake Forest Institute for Regenerative Medicine is part of a major undertaking to bring together experts from around the country to develop vision-restoring whole eye transplants. The project, valued at up to $56 million, aims to overcome technical, biological, and immunological hurdles in whole eye transplant.
Researchers developed a new approach to engineer tissue structures across multiple scales, from small cells to large organs. They used gallium as a molding material, allowing them to create complex vascular and interwoven networks that mimic natural biological systems.
The NSF-Piedmont Triad Regenerative Medicine Engine has awarded $2.5 million in grants to six innovative companies to support the commercialization of regenerative medicine products. The funding is expected to catalyze technological advancements, strengthen the local economy, and drive regional competitiveness.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
Researchers at UVA have developed a new polymer design that decouples stiffness and stretchability, allowing materials to be both strong and flexible. The 'foldable bottlebrush polymer networks' can store extra length within their structure, enabling them to elongate up to 40 times more than standard polymers without weakening.
Researchers from Texas A&M University synthesized research findings to improve medical devices and therapy success rates. The review emphasizes the need to understand macrophage cell behavior to develop targeted immunotherapy treatments.
Researchers develop novel Ta-based implants with improved biocompatibility and osseointegration properties, enabling better bone growth and stability. The designs optimize mechanical and biological requirements for optimal clinical results.
A new type of cationic epoxy photoresist exhibits greater sensitivity to two-photon laser exposure, enabling fast writing speeds and fine features. The material was developed by a research team led by Professor Cuifang Kuang, who achieved lithography speeds of 100 mm/s and resolution of 170 nm.
Scientists have successfully integrated chloroplasts from algae into hamster cells, allowing the cells to undergo photosynthesis and producing oxygen and energy. This breakthrough could lead to the development of artificial tissues that can grow in size without limitations due to low oxygen levels, paving the way for innovative biotech...
Researchers have developed a production method for a nanofibrous cellulose matrix, replacing non-renewable industrial materials with environmentally friendly alternatives. The new method has potential biomedical applications due to its biocompatibility properties.
Researchers on the International Space Station have developed human liver tissues with enhanced functionality in microgravity, paving the way for novel stem cell-derived liver tissues and alternative to traditional liver transplants. The team also created a bioreactor system for stable supercooling preservation of tissues.
Concordia researchers develop a novel method of 3D printing using acoustic holograms, capable of creating complex objects quickly and at once. This technique, called holographic direct sound printing (HDSP), stores information of multiple images in a single hologram, allowing for the creation of multiple objects simultaneously.
Researchers developed a tri-culture heart-on-a-chip model of cardiomyocytes, fibroblasts, and endothelial cells to mimic in vivo cardiac behavior. The study successfully replicated endothelial cell morphology and functionality, as well as cardiac function with increased contractility.
Dr. Josephine Wu's project, OPTO-BIOPRINTING, aims to develop a novel platform for spatiotemporally guided tissue engineering using cellular self-assembly and light triggering. The goal is to create living organ replacements that can perform as well as native equivalents.
Researchers led by Prof. Michael Brand successfully regenerated photoreceptors in zebrafish, demonstrating they regain their normal function and allowing the fish to recover complete vision. This breakthrough could potentially revolutionize treatment of diseases like retinitis pigmentosa or macular degeneration.
A new implant has been developed to encourage nerve cell repair after spinal cord injury. The implant uses electrical signals and a 3D-printed scaffold to bridge the gap and direct axons to grow back in the correct formation, promoting healing and recovery.
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
Scientists have developed a new way to 3D print materials that are strong enough to support human tissue and vary in shape and size. The breakthrough, known as CLEAR, helps pave the way toward a new generation of biomaterials for personalized implants and tissues.
The new journal Cell Organoid aims to push the boundaries of knowledge in organoid research, fostering innovation and collaboration across disciplines. The journal seeks to advance personalized medicine and therapeutic interventions by addressing ethical, technical, and standardization challenges.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
Researchers developed core-shell microfibrous scaffolds that excel in rotator cuff repair, restoring natural morphology and mechanical properties. The acellular, in situ tissue engineering technology harnesses stem cell regenerative abilities to provide robust biological regeneration without cell seeding.
A UVA research team has developed biomaterials with controlled mechanical properties matching those of various human tissues, representing a significant leap in bioprinting technologies. Their unique digital assembly of spherical particles (DASP) technique can deposit particles of biomaterial in a supporting matrix to build 3D structur...
Professors Philip LeDuc and Burak Ozdoganlar have developed a novel 3D ice printing technique that enables the creation of micro-scale structures with tailored geometries. Their method uses water as an ink substitute, allowing for the deposition of precise internal voids and channels.