Articles tagged with Tissue Engineering
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MIT engineers have developed a way to grow artificial muscles that twitch and flex in multiple coordinated directions. This breakthrough allows for the creation of soft, wiggly robots with enhanced flexibility and range of motion.
Researchers have made significant progress in applying tissue engineering to spinal cord injury (SCI) repair. Biomaterials such as hydrogels and decellularized extracellular matrix promote nerve regeneration, while stem cells and exosomes enhance functional recovery.
Researchers have developed a method to repair complex knee injuries using cartilage implants made from nasal septum cells. The study shows that longer maturation periods of the implant lead to better clinical efficacy and tissue composition.
Researchers developed mini biohybrid rays using cardiomyocytes and rubber, demonstrating improved swimming efficiencies approximately two times greater than previous biomimetic designs. The application of machine-learning directed optimization enabled an efficient search for high-performance design configurations.
Researchers at Rice University have discovered a new method for customizing engineered living materials (ELMs) by altering protein matrices. The study revealed that small genetic changes can significantly impact the behavior of these materials, making them ideal for applications like tissue engineering and drug delivery.
Researchers reviewed recent developments on functional scaffolds for bone tissue engineering, highlighting their potential for enhanced oxygen transport and cell differentiation. The study aims to inspire novel solutions for bone regeneration through the use of biocompatible and biodegradable materials with 3D printing techniques.
Seoul National University researchers create bioink from Kombucha SCOBY nanocellulose, suitable for in vivo tissue engineering. The bioink can be precisely applied directly onto damaged tissues using a digital biopen, paving the way for more personalized and effective wound healing.
A global team of scientists has made a groundbreaking discovery of a new skeletal tissue called lipocartilage, composed of fat-filled cells that provide super-stable internal support. This unique tissue has immense potential for treating facial defects, birth injuries, and cartilage-related conditions.
Lehigh University bioengineering researcher Tomas Gonzalez-Fernandez is exploring how combining CRISPR with biomaterials can improve gene editing's safety and efficacy for therapeutic use. His NSF CAREER award-funded research aims to develop more targeted and controlled therapies for genetic diseases.
Researchers at University of California, Irvine have discovered a new type of skeletal tissue that offers great potential for advancing regenerative medicine and tissue engineering. The 'lipocartilage' tissue is uniquely packed with fat-filled cells called lipochondrocytes that provide super-stable internal support.
The Wake Forest Institute for Regenerative Medicine is part of a major undertaking to bring together experts from around the country to develop vision-restoring whole eye transplants. The project, valued at up to $56 million, aims to overcome technical, biological, and immunological hurdles in whole eye transplant.
Researchers developed a new approach to engineer tissue structures across multiple scales, from small cells to large organs. They used gallium as a molding material, allowing them to create complex vascular and interwoven networks that mimic natural biological systems.
The NSF-Piedmont Triad Regenerative Medicine Engine has awarded $2.5 million in grants to six innovative companies to support the commercialization of regenerative medicine products. The funding is expected to catalyze technological advancements, strengthen the local economy, and drive regional competitiveness.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
Researchers at UVA have developed a new polymer design that decouples stiffness and stretchability, allowing materials to be both strong and flexible. The 'foldable bottlebrush polymer networks' can store extra length within their structure, enabling them to elongate up to 40 times more than standard polymers without weakening.
Researchers from Texas A&M University synthesized research findings to improve medical devices and therapy success rates. The review emphasizes the need to understand macrophage cell behavior to develop targeted immunotherapy treatments.
Researchers develop novel Ta-based implants with improved biocompatibility and osseointegration properties, enabling better bone growth and stability. The designs optimize mechanical and biological requirements for optimal clinical results.
Scientists have successfully integrated chloroplasts from algae into hamster cells, allowing the cells to undergo photosynthesis and producing oxygen and energy. This breakthrough could lead to the development of artificial tissues that can grow in size without limitations due to low oxygen levels, paving the way for innovative biotech...
Researchers have developed a production method for a nanofibrous cellulose matrix, replacing non-renewable industrial materials with environmentally friendly alternatives. The new method has potential biomedical applications due to its biocompatibility properties.
A new type of cationic epoxy photoresist exhibits greater sensitivity to two-photon laser exposure, enabling fast writing speeds and fine features. The material was developed by a research team led by Professor Cuifang Kuang, who achieved lithography speeds of 100 mm/s and resolution of 170 nm.
Researchers on the International Space Station have developed human liver tissues with enhanced functionality in microgravity, paving the way for novel stem cell-derived liver tissues and alternative to traditional liver transplants. The team also created a bioreactor system for stable supercooling preservation of tissues.
Concordia researchers develop a novel method of 3D printing using acoustic holograms, capable of creating complex objects quickly and at once. This technique, called holographic direct sound printing (HDSP), stores information of multiple images in a single hologram, allowing for the creation of multiple objects simultaneously.
Researchers developed a tri-culture heart-on-a-chip model of cardiomyocytes, fibroblasts, and endothelial cells to mimic in vivo cardiac behavior. The study successfully replicated endothelial cell morphology and functionality, as well as cardiac function with increased contractility.
Dr. Josephine Wu's project, OPTO-BIOPRINTING, aims to develop a novel platform for spatiotemporally guided tissue engineering using cellular self-assembly and light triggering. The goal is to create living organ replacements that can perform as well as native equivalents.
Researchers led by Prof. Michael Brand successfully regenerated photoreceptors in zebrafish, demonstrating they regain their normal function and allowing the fish to recover complete vision. This breakthrough could potentially revolutionize treatment of diseases like retinitis pigmentosa or macular degeneration.
A new implant has been developed to encourage nerve cell repair after spinal cord injury. The implant uses electrical signals and a 3D-printed scaffold to bridge the gap and direct axons to grow back in the correct formation, promoting healing and recovery.
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
Scientists have developed a new way to 3D print materials that are strong enough to support human tissue and vary in shape and size. The breakthrough, known as CLEAR, helps pave the way toward a new generation of biomaterials for personalized implants and tissues.
The new journal Cell Organoid aims to push the boundaries of knowledge in organoid research, fostering innovation and collaboration across disciplines. The journal seeks to advance personalized medicine and therapeutic interventions by addressing ethical, technical, and standardization challenges.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
Researchers developed core-shell microfibrous scaffolds that excel in rotator cuff repair, restoring natural morphology and mechanical properties. The acellular, in situ tissue engineering technology harnesses stem cell regenerative abilities to provide robust biological regeneration without cell seeding.
A UVA research team has developed biomaterials with controlled mechanical properties matching those of various human tissues, representing a significant leap in bioprinting technologies. Their unique digital assembly of spherical particles (DASP) technique can deposit particles of biomaterial in a supporting matrix to build 3D structur...
Professors Philip LeDuc and Burak Ozdoganlar have developed a novel 3D ice printing technique that enables the creation of micro-scale structures with tailored geometries. Their method uses water as an ink substitute, allowing for the deposition of precise internal voids and channels.
Researchers have developed a biodegradable scaffold to facilitate bladder tissue growth, reducing complications associated with traditional augmentation procedures. An implantable sensor also enhances patient monitoring, paving the way for improved bladder surgery outcomes.
Researchers at Duke University created an ultrathin silk membrane that helps cells grow into functional tissues used for research, enabling the development of kidney disease models. The new membrane improves communication and growth between cells, mimicking natural human organ structures.
Researchers created a prototype of 'living bioelectronics', combining bacteria, sensors, and gel to integrate with living tissue. The device reduced inflammation and improved psoriasis-like symptoms in mice, offering potential for treating various skin conditions and injuries.
The DRIVE-RM consortium, led by UMC Utrecht, aims to develop smart materials that assist the body in healing and regenerate tissues and organs using regenerative medicine. The project focuses on treating chronic diseases such as heart failure, kidney failure, and worn joints.
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
Scientists have developed mini-colon tissues that can simulate the complex process of tumorigenesis outside the body with high fidelity. These miniature organs mimic the physical structure and cellular diversity of colon tissue, allowing researchers to study colorectal cancer development and test potential therapies.
Researchers from Technion Faculty of Biomedical Engineering developed a breakthrough method for bio-printing live cells and tissues using external sound wave irradiation. The innovation enables precise localized delivery of biocompatible materials for various biomedical applications, reducing invasive surgeries and associated risks.
Researchers will develop 'live' joints with biocompatible bone and cartilage grown from human cells, aiming to scale up the technology for commercial use. The project, valued at $47.7M, targets 40 patients within five years with knee replacements.
Scientists have developed a novel maleic acid-treated bacterial cellulose gel that significantly improves bone repair outcomes. The gel's enhanced biocompatibility and osteogenic gene expression promote cell proliferation and differentiation, paving the way for potential applications in tissue engineering.
A clinical trial with PeriCord, a new tissue engineering product derived from umbilical cord and pericardium stem cells, confirms its feasibility in repairing damaged heart tissues after a heart attack. The therapy has demonstrated excellent biocompatibility and anti-inflammatory properties.
Researchers created a hydrogel that kills bacteria naturally, promotes cell growth and heals wounds more effectively than traditional gels. The gel is infused with amino acid polylysine and platelet-rich blood plasma to create properties well-suited for wound care.
Researchers develop PFBN to address mechanical challenges of intertrochanteric femur fractures, significantly reducing complications and improving patient outcomes. The study demonstrates the PFBN's ability to regulate local mechanical environment, promoting post-operative recovery for elderly patients.
Researchers at Weill Cornell Medicine have developed a novel method to create grafts that accurately replicate the human ear's anatomy and biomechanical properties. The new technique uses 3D printing and tissue engineering to produce cartilage-containing structures that mimic the ear's shape, flexibility, and elasticity.
Recent advances in tissue engineering have shown that mesenchymal stem cells (MSCs) and growth factors (GFs) can significantly enhance the regeneration of rotator cuff tendon-to-bone insertion. However, a comprehensive overview is lacking to translate these findings into clinical practice.
Scientists create a hydrogel system that can remember its shape, allowing them to control cell adhesion behavior. The elastic modulus of the hydrogel is adjusted by compressing it into different thicknesses at high temperatures.
A new study highlights the contributions of 50 top scientists from elite universities to transforming medicine through cutting-edge biomedical engineering advances. Five primary medical challenges are identified, including precision engineering for personalized care and tissue engineering for human health.
Researchers identify five grand challenges in biomedical engineering to address social needs, existing gaps, and technological limitations. The Convergence Revolution and Fourth Industrial Revolution are expected to shape the future of medicine, emphasizing interdisciplinary collaborations and next-generation training.
Researchers create a simple method to instantly bond layers made of the same or different types of hydrogels using a thin film of chitosan. The new approach has potential to broadly advance new biomaterials solutions for multiple unmet clinical needs, including regenerative medicine and surgical care.
Researchers at McGill University discovered a new mechanism for the attachment of avian eggshell membranes to their shells. This finding has significant implications for tissue engineering and biomaterial grafts, as well as reducing losses in the commercial egg and poultry industry.
University of Melbourne researchers have received a $35 million grant to develop a world-first tissue engineered cornea to treat corneal blindness. The technology has the potential to provide corneal tissue to surgeons worldwide, including countries with limited eye banks.
Researchers introduce trehalose into hydrogels to form hydrogen bond interactions, improving dehydration resistance, lubrication performance, mechanical properties, and manufacturing accuracy. This discovery proposes a new design principle for high-precision manufacturing of hydrogel materials.
The University of Rochester is establishing a new NIH-funded center focused on developing FDA-qualified drug development tools related to barrier functions in disease. Researchers will create microphysiological systems with ultrathin membranes of human cells, aiming to reduce animal trials and improve drug efficacy.
A team of engineers has developed a novel printing method called deep-penetrating acoustic volumetric printing (DVAP) that uses soundwaves to solidify biologically compatible structures in deep tissues. The technique involves a specialized ink that reacts to ultrasound waves, enabling the creation of intricate structures for biomedical...
Researchers created multicellular bots from human tracheal cells that move across surfaces and promote healing of damaged neurons in a lab dish. The discovery could lead to new therapeutic tools for regeneration, healing, and disease treatment using patient-derived biobots.
Researchers at RCSI University of Medicine and Health Sciences have developed a material that can speed up bone healing while reducing the risk of infections. The implant combines antimicrobial treatment with gene therapies to repair bone and prevent infection.
Researchers have developed additively manufactured Ti-Ta-Cu alloys that exhibit improved biocompatibility and bacterial resistance, making them a promising alternative to traditional Ti6Al4V implants. The alloys were found to display remarkable synergistic effects in improving both in vivo biocompatibility and microbial resistance.
Researchers at Rensselaer Polytechnic Institute have successfully created hair follicles in human skin tissue using 3D-bioprinting techniques. This innovation has potential applications in regenerative medicine, drug testing, and understanding the complex interactions between skin and topical products.