Articles tagged with Tissue Engineering
A new paper-thin robot powered by muscle cells can swim through a watery maze, offering a way to design small, efficient biohybrid robots. The robot uses a layer of live muscle cells that twitch in response to light, allowing it to control its direction and speed.
Researchers have developed a computational framework to design and fabricate crisscross DNA megastructures, expanding accessibility to DNA nanotechnology. This breakthrough enables the construction of complex structures with precise control, opening up new avenues for applications in fields like optics, immunology, and tissue engineering.
Researchers developed a new culture membrane that recreates the biochemical composition and soft physical environment of native intestinal tissue, enhancing intestinal cell growth and behavior. The membrane, combined with human colon organoid-derived epithelial cells, exhibited increased characteristics associated with intestinal stem ...
Researchers at CU Anschutz have developed CAR T-cell therapy to target two pathways that help colorectal tumors grow and evade the immune system, B7-H3 and IL-8. The therapy aims to provide a more durable response than traditional chemotherapy.
Researchers have discovered that each signaling pathway leaves behind a unique fingerprint of gene activity, allowing them to reconstruct signaling histories across different cell types. This AI-driven approach, called IRIS, enables scientists to comprehensively map signaling histories at an unprecedented scale, accelerating stem cell ...
A research team created an ultrathin artificial lung that reproduces the movement of alveoli, air sacs inside the lung, and demonstrates the response to influenza virus. The lung operated stably through 240,000 breaths and showed promise for studying lung disease and drug responses.
Researchers developed a versatile hydrogel platform that enables the design of customised biomaterials for tissue engineering, disease modelling, and regenerative medicine. The platform preserves the functionality of incorporated biomolecules and supports high cell viability, enabling the creation of tissue-specific environments.
A new technology developed by TAU's Sagol Center for Regenerative Medicine is approaching its first implantation in a person with paralysis following spinal cord injury. The implant, produced from the patient's own cells and tissues, aims to restore ability to stand, walk, and regain independence.
Researchers at Penn State have developed genetic 'switches' that can program 3D-printed bone tissue to grow blood vessels, enabling the regeneration of bone tissue in severe trauma or infections. The technique uses microRNA molecules to push cells down a differentiation pathway optimized for either tissue growth or vascularization.
WPI researchers develop new models to study uterine fibroids with NIH funding, building on student projects. The models will help researchers better understand and develop treatments for fibroids, which affect millions of women.
Researchers identified dormant progenitor cells in skeletal muscle that migrate to fracture sites and become bone-forming cells. Muscle is the main source of these regenerative cells, which can contribute to both normal fracture healing and heterotopic ossification.
A coral-inspired 3D-printed scaffold reprograms immune cells to promote angiogenesis and bone regeneration, shifting macrophages from inflammatory M1 state to reparative M2 state. The scaffold also enhances angiogenesis, new bone formation, and reconstruction of bone defects.
A team of researchers has developed a new way to study heart valve disorders by creating miniature, working models of the heart. The models, called assembloids, were grown from pluripotent adult stem cells and can be used to simulate various types of valve disorders, including mitral valve prolapse.
A University of Virginia researcher received a $2.1 million grant to develop advanced laboratory tissue models that could improve drug testing, deepen scientists' understanding of disease, and reduce the need for animal testing.
A multidisciplinary study has identified a novel biofilm regulatory protein called Biofilm Architecture Regulator (BatR) and its role in Pseudomonas aeruginosa infections. The discovery may lead to new targets for anti-infective treatments, including those for people with cystic fibrosis.
Researchers have developed a way to quickly create customizable synthetic blood vessel grafts in just minutes using additive manufacturing. The new technique, called Focused Rotary Jet Spinning, allows for precise control over diameter and wall thickness, making it ideal for acute trauma situations and complex pediatric heart surgeries.
Scientists at the University of Osaka have created a new technique to build blood supply systems for artificial tissues. They successfully fabricated tubular hydrogel structures with controlled lumen sizes and complex geometries, paving the way for creating vascular models that can investigate the development of fully synthetic tissues.
A new study reveals that lignin can be transformed into a bioactive material that promotes the formation of bone-like minerals while supporting the growth of bone-forming cells. The material also degrades gradually under physiological conditions, making it suitable for scaffolds intended to be replaced by newly formed bone during healing.
JMIR Publications is sponsoring the upcoming BioMedEng26 conference to promote biomedical engineering innovation. The journal JMIR Biomedical Engineering will be highlighted during the event, with Dr. Javad Sarvestan discussing its focus on cutting-edge engineering applications and peer-review process.
Researchers at MIT have created a precise way to engineer artificial blood vessels by mechanically stretching and pulling a "blood vessel on a chip". The new method, reported in the Proceedings of the National Academy of Sciences, enables controlled sprouting of new vessels and programming of their growth patterns.
Researchers at Technion-Israel Institute of Technology discovered that mature, aged cells can revert into active stem cells that regenerate damaged tissue. This finding challenges the prevailing view on tissue regeneration and implies the possibility of therapies promoting natural healing mechanisms.
Researchers will study blood samples and environmental exposures over 10 years to identify genetic, environmental, and cellular factors contributing to autoimmune diseases. The goal is to develop prevention strategies and treatments by understanding the earliest biological triggers of SARDs.
New research reveals that asthma attacks cause overproduction of extracellular proteins and growth of blood vessels in the airways. Over time, these changes lead to constriction of breathing passages, resulting in long-term respiratory issues.
Researchers found that CAR3 coordinates bone formation and regeneration by forming a molecular complex with collagen type I alpha 1 and recruiting bone sialoprotein. The study identified CAR3 as a previously unrecognized regulator of osteoblast differentiation, highlighting its potential for treating bone disorders.
A new study uses AI to identify promising chemical compounds that could develop into effective antibiotics against multi-drug resistant Neisseria gonorrhoeae. The approach has the potential to address the growing crisis of antimicrobial resistance in this fast-evolving pathogen.
Researchers developed a topical gel formulation with 4-aminopyridine to treat burn wounds, achieving near-complete closure in 21 days. The gel delivers the drug directly to the wound site, avoiding systemic risks associated with prolonged use.
Researchers at the Hebrew University of Jerusalem have created a novel method for cultivating meat using plant-derived cellulose scaffolds. This approach significantly reduces production costs by infusing growth factors directly into the scaffold, allowing for comparable tissue development with lower factor usage.
A novel therapeutic paradigm combines electroacupuncture with regenerative tissue engineering to enhance nerve regeneration and functional recovery in spinal cord injury. The study found that electroacupuncture stimulation improved neural signal transmission, suppressed neuroinflammation, and promoted myelin regeneration.
Researchers at Cincinnati Children's Hospital Medical Center have developed a new method to produce large, functional human gut organoids with nerve cells, growing them twice as fast as previous methods. These organoids can now be used for patching damage or restoring diminished functions of the small intestine, stomach, or colon.
Researchers developed cardiac organoids to address limitations of cell-based therapies in myocardial infarction. These three-dimensional tissue constructs integrate into host tissue, improve cardiac function, and reduce scar size without arrhythmogenic effects.
Researchers at McGill University have developed a rapid way to engineer blood clots that stop severe bleeding and support tissue healing more effectively. The technique, called 'click clotting,' links red blood cell surface proteins through a chemical reaction, resulting in a biocompatible clot.
Researchers from Lund University successfully harnessed the regenerative capacity of Scandinavian flatworms to accelerate wound healing in human skin models. The study found that signalling molecules from flatworm exosomes increased skin thickness and improved wound healing rates, including accelerated blood vessel regeneration.
Researchers at University of Michigan created a stem cell model that produces a yolk-sac-like structure in a human embryo, mimicking early pregnancy loss. The model uses mechanical signals to guide development and does not require genetic manipulation.
Researchers at IBEC and EMBL develop a strategy to program tissue shape changes by controlling cell orientation. The team creates living tissues with reproducible three-dimensional structures, enabling applications in tissue engineering and biohybrid robotics.
Oregon Health & Science University has received significant NIH funding to develop advanced microphysiologic models that mimic how cancers grow and respond to treatment within bone tissues. Two new awards focus on osteosarcoma and prostate cancer, aiming to improve understanding of disease spread and treatment responses.
Anand Ramamurthi, Lehigh's Peter C. Rossin Professor of Bioengineering and chair of the Department of Bioengineering, has been elected to the AIMBE College of Fellows for his groundbreaking work in regenerative technologies that can repair damaged tissues without surgery. His research aims to develop nonsurgical nanomedicines to treat ...
Researchers found that extracellular vesicles from menstrual blood stromal cells can improve cartilage function and slow tissue degradation, even in older postmenopausal women. Biomimetic scaffolds are being developed to prolong the effects of these particles, offering a potential cell-free therapy for osteoarthritis.
A team of researchers has achieved a major milestone in developing a new treatment aimed at helping the body repair damaged joints at the source. The experimental treatments have shown promising results in animal models, restoring joint tissue to near-normal levels and significantly reducing pain markers for long periods.
The Terasaki Institute for Biomedical Innovation and UCLA Technology Development Group will co-curate an Advanced Organ and Tissue Repair (AToR) session at LABEST, featuring leading experts in regenerative medicine. The session aims to accelerate the translation of breakthrough technologies into real-world clinical solutions.
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.
Researchers create living tissue at near-physiological cell density using a new bioprinting strategy called embedded 3D printing in a cell-dense suspension (EPICS). The method enables the precise fabrication of perfusable channels and dense cellular environments, mimicking real organs.
Engineered tissue grafts can take on the liver's function and help patients with liver failure. The injected cells remain viable in the body for at least two months, generating enzymes and proteins like normal hepatocytes.
A research team from Xi'an Jiaotong University has developed a method to align cells in muscle tissue using electric forces during electrohydrodynamic bioprinting. This breakthrough allows for the creation of living muscle tissues with tightly aligned cells, enabling the production of functional muscle constructs.
Researchers explore piezoelectric electrospun fibers that generate crucial electrical signals for tissue engineering and biomedical applications. These "smart" scaffolds have high flexibility, biomimetic structure, and tunable morphology, offering potential for enhanced tissue repair.
Researchers create detailed 3D reconstructions of human liver tissue, comparing healthy and cirrhotic livers, showing dysregulation of metabolite transport, reduced specialized cells, and disruption of vascular networks. The study highlights the importance of understanding organ structure for bioprinting artificial organs.
Researchers at RCSI have developed an RNA-activated implant that delivers growth-promoting particles to injured nerve cells, encouraging them to regrow after spinal cord injury. The implant helps overcome molecular barriers by silencing a gene called PTEN.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
The Rice lab will produce bioprinted, vascularized kidney tissue that augments renal function in patients with kidney disease. The implantable kidney tissue will be made from a patient's own cells combined with a bioink that supports the long-term viability of the implanted cells.
Researchers at Kyushu University discovered that cancer cells use a previously unrecognized physical mechanism called CODE to create water pressure that aids in their migration. This finding opens new avenues for therapies targeting amoeboid movement, a key strategy used by most advanced cancer cells.
Researchers developed smart 4D-printed vascular stents that expand naturally at body temperature, eliminating the need for external heating. The stents balance mechanical flexibility and radial strength, demonstrating long-term biomechanical compliance.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
The EMBL-IBEC conference brings together experts to discuss recent breakthroughs in multicellular living systems, including organoids and embryonic development. The event will focus on disease modeling, developmental biology, and regenerative medicine applications.
A multidisciplinary team of world-leading experts is developing an off-the-shelf engineered product that could address liver failure in millions of patients. The ImPLANT project aims to create synthetic biology-based gene circuits in human induced pluripotent stem cells to drive cell differentiation into all required liver cell types.
A Japanese research team has developed a biohybrid approach that works inside the body, transforming engineered skin into a visible indicator of internal biological states. The system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling.
Researchers at TU Wien developed a 3D bioprinting technique to create living biological tissue for studying skin diseases. The method offers a controlled and highly reproducible manner to produce tailor-made structures for different purposes, such as psoriasis and inflammatory models.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Scientists have created a complex tissue model of human bone marrow using only human cells, replicating the cellular complexity of the body's 'blood factory'. This breakthrough reduces the need for animal experiments in blood cancer research and potentially enables personalized therapies.
Researchers have successfully engineered functional brain-like tissue without animal-derived materials, opening doors to more controlled and humane neurological drug testing. The new material functions as a scaffold for donor brain cells and can be used to model traumatic brain injuries or neurological diseases like Alzheimer's.
Researchers developed a new type of porous gel that solves the problem of dense gels hindering the passage of microbes and immune cells. The new material supported better growth and organisation of bone marrow cells and helped the formation of structures similar to blood vessels, allowing fluids and particles to flow more efficiently.
Dr. Johnson V. John has been appointed as a standing member of the NIH's Musculoskeletal Tissue Engineering (MTE) Study Section, ensuring innovative research receives support. His expertise in biomaterials and tissue engineering will contribute to national research priorities.