New research published in the Annals of Clinical and Translational Neurology has identified three genes and their expressed proteins that may be involved in the pathogenesis of multiple sclerosis.
By comparing information on the genes and proteins expressed in the brains of thousands of individuals with and without multiple sclerosis, investigators discovered different expression levels of the SHMT1 , FAM120B , and ICA1L genes (and their proteins) in brain tissues of patients versus controls.
Studying the functions of these genes may uncover new information on the mechanisms involved in the development and progression of multiple sclerosis. "Our findings shed new light on the pathogenesis of MS and prioritized promising targets for future therapy research,” the authors wrote.
URL upon publication: https://onlinelibrary.wiley.com/doi/10.1002/acn3.51699
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About the Journal
Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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Annals of Clinical and Translational Neurology
Brain proteome-wide association study linking-genes in multiple sclerosis pathogenesis
7-Dec-2022