Parthenogenesis is a form of asexual reproduction during which unfertilized eggs begin to develop as if they had been fertilized. It occurs naturally in many plants and a few invertebrate (some bees, scorpions, parasitic wasps) and vertebrate animals (some fish, reptiles, and amphibians), but does not occur naturally in mammals. In 2007, researchers were able to chemically induce human egg cells to undergo parthenogenesis. The resulting parthenogenote has properties similar to an embryo, but cannot develop further. In this issue of the Journal of Clinical Investigation , Wolfram Zimmerman and colleagues at Georg-August-Universität Göttingen in Göttingen, Germany, demonstrated that cells from the parthenogenote function as embryonic stem cells and maintain the capacity to develop into different types of tissue. Further, they used parthenogenic stem cells to make cardiomyocytes and engineered heart muscle (myocardium) that exhibited the structural and functional properties of normal myocardium. The engineered myocardium could then be used to engraft the mice that had contributed the eggs for parthenogenesis. These studies demonstrate that parthenogenic stem cells can be used for tissue engineering. In a companion commentary, Michael Schneider of the Imperial College of London discusses how these findings could impact the development of cell replacement therapies.
TITLE:
Parthenogenetic stem cells for tissue engineered heart repair
AUTHOR CONTACT:
Wolfram Zimmermann
Georg-August-Universität Göttingen, Göttingen, DEU
Phone: +49 (0) 551 39-57 81; E-mail: w.zimmermann@med.uni-goettingen.de
View this article at: http://www.jci.org/articles/view/66854?key=31d6143cd2894a5b80d5
ACCOMPANYING COMMENTARY
TITLE:
Virgin birth: engineered heart muscle from parthenogenic stem cells
AUTHOR CONTACT:
Michael D. Schneider
Imperial College London, London, UNK, GBR
Phone: 011 44 20 7594 3027; Fax: 011 44 20 7594 3190; E-mail: m.d.schneider@imperial.ac.uk
View this article at: http://www.jci.org/articles/view/67961?key=a07301e0e8f34e261854
Journal of Clinical Investigation