A UC Riverside-led study suggests that vanillin flavoring in e-cigarettes may disrupt the normal development of embryos in pregnant women who vape. Researchers found that high concentrations of vanillin can cause human embryonic stem cells to lose pluripotency and differentiate into endoderm, potentially leading to serious developmenta...
SourceUniversity of California - Riverside·JournalHuman Reproduction·TypeExperimental study·DateAug 13, 2026
A study published in Human Reproduction found that vanillin, a common flavoring chemical in e-cigarettes, can disrupt the normal development of embryos in pregnant women who vape. High concentrations of vanillin caused cells to lose pluripotency and differentiate into endoderm, potentially leading to serious developmental issues.
SourceEuropean Society of Human Reproduction and Embryology·JournalHuman Reproduction·TypeExperimental study·DateAug 12, 2026
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A study found that transposable elements, once considered non-functional DNA, contribute to the evolution and expansion of gene regulation during neural development. The findings suggest a two-phase model of TE acquisition during evolution, involving both ancient and more recent expansions that shaped modern gene regulatory networks.
SourceKindai University·JournalGenome Biology·TypeData/statistical analysis·DateMay 12, 2026
Researchers at University of California - Riverside discovered that the primary cilium, a microscopic structure inside nearly every cell, plays a critical role in brain development. The study found that proteins associated with the cilium are directly linked to human developmental disorders and that protein production occurs directly w...
SourceUniversity of California - Riverside·JournalCell Reports·TypeExperimental study·DateMay 8, 2026
A two-step genome editing method integrates large human genomic fragments into mice, mimicking human regulatory landscapes. This platform enables the creation of physiologically relevant humanized models for therapeutic targets and disease research.
SourceThe Institute of Medical Science, The University of Tokyo·JournalNature Communications·TypeExperimental study·DateJan 16, 2026
A recent study found that Dlc1 deletion affects cardiac differentiation in mouse embryonic stem cells by activating the canonical Wnt pathway. The study showed that Dlc1 deficiency promotes mesoderm lineage specification, leading to the accumulation of cardiac progenitors and blocking their further differentiation into cardiomyocytes.
SourceCompuscript Ltd·JournalGenes & Diseases·DateDec 29, 2025
Researchers successfully established an Hmgn3-overexpressing embryonic stem cell line that exhibits advanced cellular plasticity and can differentiate into extraembryonic tissues. Overexpression of Hmgn3 enables these cells to stably contribute to the fetus, placenta, and yolk sac in vivo.
SourceScience China Press·JournalScience Bulletin·TypeData/statistical analysis·DateNov 12, 2025
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Scientists successfully derive and maintain self-renewing and pluripotent ESCs from chickens and seven other bird species using a growing medium of egg yolk. The study holds promise for applications in studying embryonic development, producing lab-grown poultry, and reviving endangered birds.
SourceKeck School of Medicine of USC·JournalNature Biotechnology·TypeExperimental study·DateSep 30, 2025
Researchers analyzed single-cell transcriptome data to reconstruct communication networks among human preimplantation lineages. They found that signaling crosstalk between tri-lineages is crucial for lineage specification and cell fate regulation during human embryonic development.
SourceScience China Press·JournalScience Bulletin·DateJul 8, 2025
Researchers have developed a novel method to generate rats with ES cell traits using blastocyst complementation. This approach eliminates the need for fluorescent labeling and reduces costs compared to conventional techniques.
SourceNiigata University·JournalGenes to Cells·DateJul 7, 2025
Researchers at the Francis Crick Institute developed a new stem cell model of the mature human amniotic sac, replicating its development from two to four weeks after fertilization. The model shows that the amnion actively communicates with embryonic cells and promotes growth.
SourceThe Francis Crick Institute·JournalCell·TypeExperimental study·DateMay 15, 2025
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Scientists at the University of Copenhagen have created 'super stem cells' that outperform regular stem cells by developing into multiple cell types. These 'super stem cells' show promise in improving fertility treatment, particularly IVF success rates, by producing essential tissue for early embryonic development.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalThe EMBO Journal·DateApr 25, 2025
A new method captures totipotency using a short-term high-dose treatment of Pladienolide B, reprogramming classical mouse embryonic stem cells into transient totipotent blastomere-like stem cells. These cells exhibit remarkable developmental potential and self-organize into blastoid structures mimicking early embryonic development.
SourceScience China Press·JournalScience China Life Sciences·TypeExperimental study·DateApr 9, 2025
Alice Rossi, Angeliki Spathopoulou, and Gareth D. Chapman received the ISSCR Outstanding Poster Award for their innovative work on quiescent neural stem cells, neural stem/progenitor cell populations, and epigenetic dysregulation in Tatton-Brown-Rahman-Syndrome.
SourceInternational Society for Stem Cell Research·DateApr 7, 2025
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Researchers at Karolinska Institutet have developed a method to track the development of cells in the nervous system and inner ear. The technique, known as ectoderm barcoding, reveals that cells in the inner ear develop from two main types of stem cells.
SourceKarolinska Institutet·JournalScience·TypeExperimental study·DateApr 3, 2025
Researchers have identified a novel mechanism of intercellular communication involving mRNA transfer between different types of stem cells. This phenomenon enables cell fate conversion and reverts human pluripotent stem cells to an earlier embryonic stage.
SourceInstitute of Science Tokyo·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMar 26, 2025
Researchers at UC Santa Cruz engineered cellular models of embryos using CRISPR technology, allowing them to study early developmental stages without experimenting with actual embryos. The team found that 80% of stem cells organized into embryo-like structures, showcasing a remarkable collective behavior and molecular composition.
SourceUniversity of California - Santa Cruz·JournalCell Stem Cell·DateMar 20, 2025
Researchers at Osaka Metropolitan University have successfully generated feline embryonic stem cells, a major breakthrough for veterinary regenerative medicine. The high-quality stem cells can differentiate into various cell types and be transplanted to restore internal damage.
SourceOsaka Metropolitan University·JournalRegenerative Therapy·TypeExperimental study·DateFeb 27, 2025
Dr. Yonatan Stelzer has made significant contributions to understanding epigenetic mechanisms and embryonic development, challenging conventional knowledge with innovative approaches. His research aims to establish fully data-driven quantitative models of spatiotemporal processes in mammals.
SourceInternational Society for Stem Cell Research·DateFeb 20, 2025
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Dr. Paola Arlotta's groundbreaking research on stem cell-derived brain organoids has redefined human brain development and neurological disease understanding. Her work provides access to the complexities of developing human brains, making her a deserving recipient of the ISSCR Momentum Award.
SourceInternational Society for Stem Cell Research·DateFeb 20, 2025
Dr. Gordon Keller's groundbreaking research on directed differentiation of human pluripotent stem cells has illuminated the path to transforming human health. His lab's world-first discovery and pioneering efforts have pushed the boundaries of what is possible, offering hope for regenerating heart, liver, and blood cells.
SourceInternational Society for Stem Cell Research·DateFeb 20, 2025
Researchers discovered a novel mechanism of intercellular communication through mRNA transfer between stem cells, allowing for biologically significant effects such as cell fate conversion and pluripotent state maintenance.
SourceInstitute of Science Tokyo·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 19, 2025
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Scientists discovered a novel method to activate extraembryonic trophoblast potentials in conventional human pluripotent stem cells through transient treatment of epigenetic regulators. This approach holds promise for advancing understanding and treatment of diseases related to placental development.
SourceScience China Press·JournalScience China Life Sciences·TypeExperimental study·DateFeb 14, 2025
Researchers successfully created a bi-paternal mouse by modifying genes involved in reproduction. The mice that reached adulthood exhibited altered growth and shortened lifespan, but could potentially lead to new therapeutic strategies for imprinting-related diseases.
SourceCell Press·JournalCell Stem Cell·TypeExperimental study·DateJan 28, 2025
The ISSCR has appointed Lizhong Liu, Kate MacDuffie, and Mubeen Goolam as the third cohort of Lawrence Goldstein Science Policy Fellows. The fellows will serve for three years and focus on science policy and advocacy work in regenerative medicine.
SourceInternational Society for Stem Cell Research·DateJan 23, 2025
Janet Rossant takes over as Editor-in-Chief of Stem Cell Reports, aiming to publish high-quality primary research articles and commentaries that shape the field of stem cell science. She brings extensive experience and scientific expertise to the position, previously serving as ISSCR President.
SourceInternational Society for Stem Cell Research·DateJan 14, 2025
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A USC Stem Cell study has identified key gene regulators that enable some deafened animals, including fish and lizards, to naturally regenerate their hearing. The researchers found a class of DNA control elements known as 'enhancers' that amplify the production of a protein called ATOH1, which induces sensory cells in the inner ear.
SourceKeck School of Medicine of USC·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 9, 2024
An international team of researchers successfully created a mouse using genetic tools from a unicellular organism, challenging the notion that these genes evolved exclusively within animals. The study uses ancient genetic tools to reprogram mouse cells into pluripotent stem cells.
SourceQueen Mary University of London·JournalNature Communications·DateNov 18, 2024
A team of researchers at the University of Toronto has discovered a unique stem cell type, the neural crest stem cell, which can be reprogrammed into different cell types. This discovery challenges longstanding theories in cellular reprogramming and highlights the potential of these cells for stem cell transplantation to treat disease.
SourceUniversity of Toronto·JournalCell Reports·DateNov 1, 2024
Researchers at Kumamoto University have achieved a groundbreaking advancement in stem cell biology by reproducing the developmental process of hematopoietic stem cells in vitro. This culture system enhances our understanding of HSC development and has the potential to be instrumental in stem cell therapy and blood disease treatments.
SourceKumamoto University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateOct 18, 2024
The ISSCR 2025 Annual Meeting will bring together stem cell scientists from diverse backgrounds to share knowledge and collaborate on innovative research. Scientists can submit abstracts by January 21, 2025, for oral presentations and qualify for awards.
SourceInternational Society for Stem Cell Research·DateOct 2, 2024
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Researchers at Johns Hopkins University mapped variation in human stem cells, revealing unique developmental patterns and gene expression traits that modify conserved steps. The findings may aid personalized regenerative therapies and advance understanding of cellular variation in humans.
SourceJohns Hopkins Medicine·JournalStem Cell Reports·DateSep 25, 2024
Researchers at Iowa State University have discovered a potential breakthrough in producing lab-grown blood stem cells by pausing the initial activation of inflammatory signals. This allows for the production of hundreds of functional stem cells, which could replace bone marrow transplants for blood disorders such as leukemia and anemia.
SourceIowa State University·JournalNature Communications·TypeExperimental study·DateSep 9, 2024
Researchers found a strikingly similar pluripotency gene network across jawless and jawed vertebrates, suggesting a common evolutionary origin. The study reveals that the loss of the pou5 gene in lampreys' neural crest cells may have limited their ability to form cell types found in jawed vertebrates.
SourceNorthwestern University·JournalNature Ecology & Evolution·DateJul 26, 2024
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Researchers discovered a breakthrough in mouse embryo development, where primitive endoderm cells can generate an embryo on their own. These cells also have the potential to improve IVF outcomes by developing into stem cell-based embryo models.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalCell·DateJun 24, 2024
A new study using stem cell-based models has revealed how early embryo cells decide between contributing to the foetus or to the supporting yolk sac. Understanding this decision is crucial for infertility treatment using in vitro fertilized (IVF) embryos, as producing the right number of yolk sac forming cells may be critical.
SourceUniversity of Exeter·JournalCell Stem Cell·TypeExperimental study·DateMay 31, 2024
Researchers have uncovered a novel regulator governing how cells respond to mechanical cues, finding that ETV4 bridges cell density dynamics to stem cell differentiation. This discovery has significant implications for controlling cancer cells through mechanical cues.
SourcePohang University of Science & Technology (POSTECH)·JournalNature Cell Biology·DateMay 9, 2024
A recent study published in Nature Cell Biology found that increased hydrostatic pressure can hinder the healthy development of neural crest cells, leading to an increased risk of facial malformations. The researchers suggest that physical cues in the womb, such as pressure, may play a role in shaping facial features.
SourceUniversity College London·JournalNature Cell Biology·TypeExperimental study·DateApr 22, 2024
Researchers have developed a cell culture system that differentiates human pluripotent stem cells to amniotic and surface ectoderm, which are essential for human embryo development. The study found that the degree of cell crowding influences cell identity decision.
SourceBabraham Institute·JournalScience Advances·TypeExperimental study·DateMar 4, 2024
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Researchers discover a virus, MERVL, plays a critical role in embryonic development by regulating gene expression and ensuring smooth transition from totipotency to pluripotency. This finding has significant implications for regenerative medicine and artificial embryo creation.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalScience Advances·TypeExperimental study·DateJan 24, 2024
Researchers discovered that PDS5A modifies DNA loops without affecting histone modifications, enabling the study of loop-mediated gene silencing. The loss of PDS5A disrupted genome organization, leading to aberrant gene activation and potentially driving diseases like cancer and developmental disorders.
SourceKeck School of Medicine of USC·JournalNature Communications·TypeExperimental study·DateJan 16, 2024
Researchers successfully created a rat-derived lung in mouse model using reverse-blastocyst complementation and tetraploid-based organ complementation. The study identified crucial factors required for functional lung formation, including fibroblast growth factor 10 (Fgf10) and its interaction with Fgfr2b.
SourceNara Institute of Science and Technology·JournalDevelopment·DateJan 5, 2024
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
SourceIowa State University·JournalNature Communications·TypeExperimental study·DateDec 19, 2023
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Scientists successfully created a live-birth chimeric monkey with a high contribution of human embryonic stem cells, breaking the record for successful chimerism in nonhuman primates. The study showcases the potential for using ESCs to generate complex gene-modified models.
SourceChinese Academy of Sciences Headquarters·JournalCell·DateNov 9, 2023
Researchers in China have reported the groundbreaking achievement of creating a live birth of a chimeric monkey using embryonic stem cell lines. The study demonstrates the ability of these cells to differentiate into various tissues in vivo, opening up new possibilities for genetic engineering and species conservation. Analysis reveale...
SourceCell Press·JournalCell·TypeExperimental study·DateNov 9, 2023
A foundational public dialogue project in the UK found broad public support for extending the 14-day rule on human embryo research, which aims to inform future policy development and research governance. The project engaged diverse participants to consider early human embryo research and its applications.
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Researchers discovered an anti-nucleolin DNA aptamer that modulates gene expression and nucleolin localization to determine a cell's lineage during differentiation. The study shows promise as a regenerative therapy for cardiovascular diseases.
SourceShinshu University·JournalInternational Journal of Molecular Sciences·TypeExperimental study·DateOct 10, 2023
Researchers have developed a new method to study the inner workings of cell nuclei during embryonic stem cell differentiation. By using fluorescent proteins, they found that biomaterials become more uniformly distributed as cells mature, resembling oil droplets in water, but with intriguing complexities.
SourceThe Hebrew University of Jerusalem·JournalNature Communications·TypeExperimental study·DateSep 10, 2023
A groundbreaking study from the University of Copenhagen sheds light on the significance of transmitting epigenetic information during cell division for proper function of embryonic stem cells. The researchers found that histones play a crucial role in maintaining epigenome stability and cell identity.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalNature Genetics·DateSep 4, 2023
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
Researchers from the Wellcome Sanger Institute mapped the multiple organ functions of the human yolk sac, revealing its role in producing key hormones and blood cells. The study provides novel insights into the earliest stages of immune cell development and has implications for understanding childhood diseases.
SourceWellcome Trust Sanger Institute·JournalScience·TypeObservational study·DateAug 17, 2023
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Researchers found that epigenetic silencing shuts off key genes required for sensory cell conversion. Enzyme TET can remove methyl groups to reverse gene silencing and restore hearing capability. Progenitor cells in deaf ears may already be primed to convert into sensory hearing cells.
SourceKeck School of Medicine of USC·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 14, 2023
A study published in Nature Cell Biology found that blood stem cell diversity arises during embryonic development and can be manipulated in childhood to improve overall health. The researchers used zebrafish and human pluripotent stem cells to demonstrate the potential of enhancing blood stem cell production.
SourceYale University·JournalNature Cell Biology·DateJul 17, 2023
A study by Gladstone Institutes researchers found that tight junctions between cells may play a critical role in gastrulation in human embryos. By suppressing tight junction formation, the team was able to create primordial germ cell-like cells, which are stem cells resembling human precursors of sperm and egg cells.
SourceGladstone Institutes·JournalDevelopmental Cell·DateJul 17, 2023
A collaborative study by researchers at the University of Ottawa and McMaster University has made a groundbreaking discovery linking different types of cancers to their embryonic origins. The team found that drugs targeting specific embryonic pathways can effectively treat various tumors, including brain, colon, and leukemia cancers.
SourceUniversity of Ottawa·JournalCell Chemical Biology·TypeData/statistical analysis·DateJun 28, 2023
Researchers compared developmental time across six species, including humans and mice, to find that embryonic duration is a key factor. They also discovered correlations between evolutionary history and segmentation clock periods.
SourceEuropean Molecular Biology Laboratory·JournalCell Stem Cell·TypeExperimental study·DateJun 20, 2023
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Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
SourceWeill Cornell Medicine·JournalNature Cell Biology·DateMay 25, 2023
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
SourceXi'an Jiaotong-Liverpool University·JournalNano Letters·TypeExperimental study·DateMay 8, 2023
Researchers developed a self-organizing system that models key cellular processes involved in embryogenesis, shedding light on the self-organization of ectodermal cells during neurulation. The study could inform ways to prevent or counteract central nervous system birth defects by optimizing human ectodermal development.
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Scientists have created a detailed map of human spinal cord cell formation, shedding light on how injuries and diseases arise. The study's findings hold promise for developing new therapies for spinal cord injuries and diseases like ALS.
SourceKarolinska Institutet·JournalNature Neuroscience·TypeExperimental study·DateApr 26, 2023