Articles tagged with Embryonic Stem Cells
Researchers have developed a new technology to sequence individual mitochondria in single cells, allowing for unbiased analysis of full-length mtDNA. This has revealed complex patterns of pathogenic mtDNA mutations and the potential risks of off-target mutations in genetic editing strategies.
A team of investigators created embryo-like structures from monkey embryonic stem cells and transferred them into female monkeys, which implanted and elicited a hormonal response similar to pregnancy. The study provides new tools and perspectives for exploring primate embryos and reproductive medical health.
A new study led by OHSU researchers reveals that gene editing technology in human embryos can lead to unintended changes in the genome and may not accurately reflect gene edits. The study highlights the need for caution when using genetically edited embryos to establish pregnancies.
A patient with Parkinson's disease has received a pioneering stem cell-based transplant at Skåne University Hospital in Sweden. The procedure aims to replace lost dopamine nerve cells and is part of a clinical trial testing the safety and efficacy of this innovative treatment, which could potentially help millions of people worldwide.
Researchers at La Jolla Institute for Immunology have discovered that OGT regulates mTOR, a key protein for mitochondrial powerhouses, keeping cells healthy. The study may lead to important medical advances in understanding cancers, diabetes, and cardiovascular disease.
A new stem cell model allows researchers to study the earliest stages of sex determination in mice and humans, providing insights into Disorders of Sex Development (DSD). The model enables the creation of a 'mini testis' in a dish, which could lead to better understanding of DSD, infertility, and fertility restoration.
A new report by The Hastings Center recommends clearer ethics guidelines and enhanced oversight for human-animal chimera research, which raises questions about animal welfare and moral status. The report also highlights the potential benefits of this research, including better disease models and organ transplantation.
Scientists have successfully created primordial germ cell-like cells (PGCLSs) from induced pluripotent stem cells of the northern white rhino Nabire, paving the way to produce artificial gametes. This breakthrough aims to prevent the extinction of the northern white rhinoceros and increase genetic diversity.
Researchers discovered the cellular mechanism and molecular trajectory for formation of adult pluripotent stem cells in the acoel worm Hofstenia miamia. This study provides insight into regenerative abilities of certain animals and may lead to new understanding of how stem cells are made.
Researchers at La Jolla Institute for Immunology discovered a direct link between TET protein loss of function and missing genes in embryonic stem cells, which can lead to cancer growth. The study found that TET proteins are crucial for maintaining genome stability, and their loss results in aneuploidies, a common feature of cancer cells.
Research at Kumamoto University reveals that fetal liver blood cells are stem cell-independent, contrary to the long-held view that HSCs are essential for their production. The study provides new insights into the origin of HSCs and suggests a reconsideration of their role in embryo formation.
Researchers at UNSW Sydney have made significant discoveries about embryonic blood stem cell creation that could one day eliminate the need for blood stem cell donors. Two studies have emerged from UNSW researchers in this area that shine new light on how precursors to blood stem cells occur in animals and humans, and how they may be i...
Researchers have developed a mouse embryo model using only embryonic stem cells, achieving a high level of developmental stages including beating hearts and brain formation. This advancement opens up new avenues for understanding human pregnancy loss and developing organs in culture.
Researchers at KU Leuven have developed a new model of human extraembryonic mesoderm cells, which closely resemble their natural counterparts in early embryos. This breakthrough enables scientists to study processes previously inaccessible during development.
Researchers have developed a model mouse embryo that has beating hearts, foundations for a brain, and all the organs in a mouse body. This breakthrough could help understand why some embryos fail and provide insights into repairing synthetic human organs.
Researchers at the University of Cambridge have successfully grown a model embryo with a brain, beating heart, and all other organs using mouse stem cells. This breakthrough could help understand why some pregnancies fail and develop a new approach for repairing synthetic human organs.
Researchers created genetically edited mice to label and study secretome proteins, facilitating studies of inter-organ communication. The transgenic mice enable scientists to identify specific cell types and organs, providing a valuable resource for mapping and profiling the secretome.
Researchers have identified a key chemical controlling hair follicle cell division and death, shedding light on a potential cure for baldness. The discovery also holds promise for speeding up wound healing by harnessing the regenerative properties of stem cells found in hair follicles.
A groundbreaking study by Hebrew University researchers has discovered the most primitive blueprint for embryo cell creation. The team identified 14,000 sites in the DNA that control the development of all embryonic organs.
Researchers using 'blastoids' - in vitro models of the blastocyst - discovered that early embryonic signals induce placental development and prepare the uterus. The findings may contribute to a better understanding of human fertility and potentially improve IVF procedures, fertility drugs, and contraceptives.
Researchers have developed a new protocol for differentiating human embryonic stem cells into retinal pigment epithelial (RPE) cells, which can be used to treat age-related macular degeneration. The study shows that the protocol produces a pure population of RPE cells that can continue maturing after transplantation, paving the way for...
Researchers have discovered an alternative route that pluripotent and endoderm extra-embryonic stem cells can use to form intestinal organs in the lab. This finding could lead to improved cell development and potentially treat diseases, but further function testing is needed.
A study reveals an epigenetic switch that restricts early embryo cells from differentiating into certain tissue lineages. The research identifies PRC2 as a key regulator of gene expression in embryonic development, allowing for better control of stem cell specialization and blastoid formation.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
Scientists found that lithium chloride can cause X-inactivation loss in female hESCs, leading to cell death. The study suggests a possible new model for regulating X-inactivation and warns against using GSK-3 inhibitors like lithium.
Researchers have developed a process to convert non-neuronal cells into functioning neurons that can take up residence in the brain and restore capacities undermined by Parkinson's destruction of dopaminergic cells. In a proof-of-concept study, one group of experimentally engineered cells performs optimally in terms of survival, growth...
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
A team from UNIGE demonstrates that stem cells giving rise to beta cells cease to exist after birth, and defines the 'identity card' of other hormone-producing cells. This discovery has significant implications for developing cell-based therapies to treat diabetes.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
The article highlights the need for a more diverse approach to stem cell policy, including consideration of Muslim contexts and perspectives. Researchers argue that this could lead to a more nuanced understanding of bioethics and potentially expand the use of embryonic stem cells in research.
A preclinical study suggests that SARS-CoV-2 infection can cause ferroptosis in pacemaker cells, leading to cardiac arrhythmias. Researchers used animal models and human stem cell-derived pacemaker cells to demonstrate the virus's impact on these cells.
Researchers use stem cells from people with extra X chromosomes to identify key genes contributing to symptoms like infertility and intellectual disability. The study's findings could lead to new treatments for these conditions.
Researchers developed a transgene-free method to convert human pluripotent stem cells into 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology. These cells can be used to regenerate human organs, study human embryonic development, and prevent pregnancy loss.
Researchers discovered a new human embryonic stem cell population that closely resembles the 8-cell embryo stage, allowing them to map key genomic changes during early development. This model will help advance knowledge of genome activation errors in developmental disorders and embryo loss.
Researchers around Christian Schröter and Luis Morelli have discovered that ERK activity pulses every six to seven minutes in living stem cells, encoding differentiation information. This intermittent oscillation is believed to be a morse code-like mechanism that helps stem cells make decisions about fate.
Researchers discovered YAP1 is a master regulator of Nodal signaling in human embryonic stem cells, crucial for human development. The study found that YAP1 regulates the allocation of germ layers and dictates the production of Nodal protein, essential for gastrulation.
Researchers from Tel Aviv University have engineered 3D human spinal cord tissues and implanted them in lab models with long-term chronic paralysis, resulting in an 80% success rate in restoring walking abilities. The team aims to conduct clinical trials in human patients within a few years to make the treatment commercially available.
A team of researchers at Kumamoto University successfully created complex 3D kidney tissue in the lab using mouse embryonic stem cells. The breakthrough could lead to advances in kidney research and potentially even transplantable organs.
A recent study by Gladstone Institutes researchers found that mouse stem cells can spontaneously transition from heart cell precursors to brain cell precursors when a specific gene is removed. This discovery upends current understanding of how stem cells differentiate into adult cells and maintain their identity. The study's findings h...
Researchers at RIKEN have developed a new retinal transplant technique by engineering human-derived retina sheets to lose bipolar cells, allowing better connections to host retinas and improved responses to light. The technique has shown substantial functional improvement in animal studies and is now poised for human clinical trials.
Researchers at Rice University have discovered that the Lefty protein plays a crucial role in regulating Nodal signaling during embryonic development. By visualizing the interaction between Nodal and Lefty, they found that cells relay the signal to produce new Nodals, triggering a wave of differentiation. This study provides new insigh...
Researchers from the Crump Lab created a series of atlases to study the molecular decisions of cranial neural crest cells, identifying genetic signs that point to specific destinies. Their findings reveal a new approach to understanding head development and regeneration in vertebrates.
Researchers developed a single-cell epigenetic aging clock to profile biological age in individual cells. The technique revealed mechanisms driving aging, attenuation, and early embryogenesis-related rejuvenation, opening possibilities for clinical applications in mammalian cells.
Scientists at the University of Bonn have developed a method to generate embryo-like cell complexes from mouse stem cells. The resulting embryoids exhibit coordinated development similar to natural embryos, offering a promising alternative to animal testing for toxicology studies.
Researchers from UNIGE found that a single missing genetic switch can lead to clubfoot and other malformations by disrupting cellular activation. The study highlights the crucial role of genetic switches in developmental disorders, suggesting that flaws in these mechanisms may be responsible for numerous malformations.
Researchers at University College London discovered that embryonic cells can navigate towards harder regions using chemical and mechanical signals, guiding the formation of facial features. This breakthrough could help prevent birth defects and infant mortality by improving understanding of cell migration mechanisms.
Researchers have discovered molecules that could be candidates for contraceptives or fertility enhancers using human blastoid models. These models also show promise in improving the self-organization of stem cells during IVF procedures.
A study led by Children's Hospital of Philadelphia researchers used stem cells to implicate several genes involved in bodily functions associated with the hypothalamus. The findings could help clinicians identify potential causes of dysfunction for traits regulated by the hypothalamus, such as sleep and stress.
Researchers found that stem cell specialization is dependent on communication between cells through messenger substances like growth factors. Even manipulating the 'dice' by artificially increasing GATA did not lead to arbitrary increases in fruit bladder precursor cells, indicating a need for more than chance in development.
A genome-wide screening technique reveals the interrelated activities of genes controlling pluripotency and apoptosis in human embryonic stem cells. The study provides new insights into cancer genetics and a novel approach for regenerative medicine research, enabling the systematic mapping of genetic networks involved in tissue formation.
Researchers have made a breakthrough in spermatogonial stem cell research, successfully generating functional sperm cells using primate embryonic stem cells. The study, published in Fertility and Sterility Science, shows promise for future clinical therapies to treat male infertility.
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
Caltech researchers have developed a technique to build embryo-like structures from human stem cells, opening up new possibilities for studying early human development. The technology can generate large quantities of these structures without the need for donated embryos.
Researchers at Kyushu University successfully reconstitute the ovarian follicle from mouse stem cells, generating functional egg cells and growing viable mice. This breakthrough could lead to new treatments for infertility and help conserve endangered animals through egg cell production.
Researchers at KAUST have developed an in vitro model of early human embryogenesis using extended pluripotent stem cells, overcoming ethical concerns. The model, called EPS-blastoids, is a faithful representation of the earliest moments of human development and holds promise for studying developmental defects and regenerative medicine.
Researchers have successfully cultivated complex retinal tissue from embryonic stem cells of medaka and zebrafish. The study, published in eLife, demonstrates the feasibility of growing retina-like structures in a Petri dish, offering new insights into retinal development and potential applications for human medicine.
A team of scientists at the University of Cambridge has developed a lab-grown model of heart cells that mimic the behavior of real heart cells and are vulnerable to SARS-CoV-2 infection. The researchers showed that an experimental peptide drug, DX600, can prevent the virus from entering the heart cells and reduce levels of infection.
Gladstone researchers have discovered a molecular mechanism that boosts the 'noise' of gene expression in stem cells, accelerating their ability to differentiate into other cell types. The DiThR pathway involves a DNA repair process that increases noise across the genome, making cells more responsive to signals guiding their fate.
Researchers at ETH Zurich developed a new chip-based test that incorporates the placenta into embryotoxicity assessments. The test detects indirect damage to embryos by analyzing stress responses of human placental cells to toxic substances.
Research found that cells with defective mitochondria and sequence changes in their genome are 'loser' cells in mouse embryos, suggesting that mitochondrial dysfunction is a common characteristic of competing cells. The study suggests that mitochondrial activity may be a key determinant of cellular fitness in various biological contexts.