Articles tagged with Embryonic Stem Cells
Researchers at Gladstone Institutes develop a three-dimensional human spinal cord organoid that mimics the earliest developmental steps of the nervous system in embryos. The organoid demonstrates how human spinal cord cells become oriented in an embryo, shedding light on potential impact of environmental exposures and toxins.
Scientists at UC Santa Barbara and Regenerative Patch Technologies have developed a new cryopreservation method for stem cell-based therapy for age-related macular degeneration. The method allows for long-term storage and distribution of the implant, extending shelf life and increasing accessibility to patients.
A study by MUSC researchers found that the transcription factor GATA6 plays a crucial role in liver cell development, allowing cells to differentiate into liver cells rather than other types. This finding could provide insight into how inherited liver diseases occur in children.
Scientists at Gladstone Institutes create an artificial intelligence system that can follow hundreds of cells in a petri dish, revealing key findings on cell behavior and leadership patterns. The AI approach provides a comprehensive view of how cells cooperate and form complex organs, with potential applications for therapeutic purposes.
Rice University neurobiologist Rosa Uribe wins $2 million NIH grant to study enteric nervous system development in zebrafish embryos. The 5-year study aims to decipher the mechanisms of neural crest cell transformation into neurons and other cell types.
Researchers at the University of Exeter have discovered a method to recreate the early structure of the human embryo from stem cells in the laboratory. This approach enables the study of human fertility and reproduction, with potential benefits for infertility research and IVF procedures.
Researchers successfully generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos. The study provides strong evidence that the system is a good model for studying early embryo development, shedding light on the mechanisms of totipotency and the causes of early pregnancy loss.
Scientists at Université libre de Bruxelles discover a new mechanism behind the development of metaplasia in the oesophagus, a precursor to esophageal adenocarcinoma. The study reveals that reactivation of the Hedgehog pathway triggers cellular changes leading to the conversion of squamous cells into columnar cells.
Scientists have successfully generated human-monkey chimeric embryos, allowing them to study human development and disease under in vivo conditions. The research has the potential to provide new insights into evolutionary barriers to chimera generation and improve model systems for studying human biology.
USC Stem Cell scientist Leonardo Morsut is designing artificial genetic programs to study embryonic development using a $2.5 million NIH grant. He has developed a synthetic version of the naturally occurring Notch system, allowing him to control cell behavior and signaling networks.
The new approach provides a powerful tool for recording cell lineage in diverse cellular systems. Researchers use intMEMOIR to reconstruct lineage histories and link cell fate, spatial structure, and tissue organization in mouse embryonic stem cells and fruit fly brain.
Researchers have discovered a unique regenerative property of human early embryo cells, allowing them to regenerate trophectoderm and produce placental cell types. This breakthrough may benefit assisted conception treatments and help understand causes of infertility and miscarriage.
A new RNA-sequencing method, PANDORA-seq, can detect modified small RNAs that were previously undetectable. The method employs a stepwise enzymatic treatment to remove key RNA modifications, uncovering a surprising small-RNA landscape dominated by tsRNAs and rRNA-derived small RNAs.
Researchers created living organisms that self-assemble, move faster, and demonstrate recordable memory. These 'Xenobots' can work together in groups, heal themselves, and perform tasks like garbage collection.
A study by researchers at Warwick Medical School reveals that decidual precursor cells play a critical role in pregnancy and their depletion may lead to recurrent pregnancy loss. The study suggests that these cells can be harnessed to prevent pregnancy disorders, offering new hope for women struggling with miscarriage.
Mouse embryos can now be grown outside the womb for up to six days, allowing researchers to observe early stages of development in unprecedented detail. The method, developed by Weizmann Institute of Science researchers, enables detailed study of embryonic development and potential insights into birth defects.
Researchers at University of Tsukuba have developed a novel technique for transplanting HSCs into mouse embryos without destroying the host hematopoietic system. This breakthrough enables the study of fetal hematopoiesis and paves the way for future humanization using human HSCs.
Researchers discovered that epithelial cells in developing embryos can recognize and destroy defective cells through a process called epithelial phagocytosis. This early immune response may aid efforts to understand embryonic developmental failure and lead to new clinical applications in treating infertility.
Researchers at Tokyo Institute of Technology create novel enterocyte-like cells that closely resemble actual enterocytes, expressing efflux transporter proteins and CYP3A4. These cells can be used as an in vitro model of the small intestine for evaluating intestinal absorption of drugs in humans.
Elvira Mass has made a significant contribution to understanding the role of yolk sac-derived macrophages in maintaining healthy organs. Her research found that these cells can self-maintain for a lifetime, producing bioactive molecules and growth factors essential for tissue development.
A new genetic disorder, LINKED, has been identified by NIH researchers, characterized by developmental delays and malformations of the brain, heart, and facial features. The disorder is caused by mutations in the OTUD5 gene, which interferes with key molecular steps in embryo development.
Researchers identify a unique population of skeletal stem cells that mark a transitional phase in bone growth and maintenance, which may hold clues to preventing osteoporosis. The study's findings provide new insights into the regulation of these cells and their potential role in bone health.
Researchers at the University of Maryland have successfully grown human organs in pigs using stem cells, a breakthrough that could revolutionize organ transplantation and provide new therapeutic options for patients. This achievement marks a significant step towards solving the global organ shortage crisis.
Researchers at Gladstone Institutes and UCSF have discovered a complex network of genes and proteins that go awry in a subset of congenital heart diseases. The study sheds light on how genetic mutations contribute to the disease, offering new insights into potential prevention or treatment strategies.
New research from the University of Exeter's Living Systems Institute has found that human embryonic stem cells do not acquire cancer-causing mutations when grown in their most primitive state. The study provides a significant breakthrough in understanding the genetic stability of human pluripotent stem cells.
A team of researchers has successfully grown structures similar to parts of a mouse embryo using a special gel and 3D cell culturing technique. This allows for the investigation of pharmacological agents on a scale that would not be possible in living organisms.
Researchers at UT Southwestern Medical Center have derived a new intermediate embryonic stem cell type that can contribute to chimeras and create precursors to sperm and eggs in culture. This discovery could lead to advances in basic biology, regenerative medicine, and reproductive technology.
Scientists have identified a key gene mechanism controlling cellular aging and rejuvenation in mesenchymal stem cells. The GATA6/SHH/FOXP1 pathway regulates MSC aging and rejuvenation, offering insights into developing treatments for age-related diseases.
Researchers have identified the precise timing and molecular signals involved in neural crest cell formation, shedding light on human neural crest-related pathologies. The study provides a high-resolution temporal map of gene expression and epigenetic changes during neural crest development.
Researchers found that RNA from repetitive elements activates RIG-I-like receptors, inducing inflammation and increasing hematopoietic stem cell numbers. The RIG-I-like receptor family plays a crucial role in regulating hematopoiesis, with different members having opposing effects on developmental hematopoiesis.
Researchers from EPFL have successfully produced a mouse heart organoid in its early embryonic stages using mouse embryonic stem cells. The study mimics the early stages of heart development in the embryo, preserving crucial interactions necessary for embryonic organogenesis.
Researchers discovered that stem cells have smaller and weaker centromeres compared to differentiated cells. This finding highlights a possible mechanism for the errors in cell division that limit the potential of stem cells in regenerative medicine.
A new USC-led study provides evidence that the endoderm also forms part of the pituitary's front lobe in some vertebrates, revising the developmental and evolutionary story of the gland. The research uses cutting-edge technology to label and track embryonic cells, revealing an unexpected contribution from the innermost embryonic layer.
The MDI Biological Laboratory has received a grant to develop artificial kidney tissue to replace human kidney tissue lost due to disease or injury. The project aims to create a three-dimensional mini-organ called an organoid that can be transplanted into a host and potentially scaled to create an artificial human kidney.
Researchers found that compressing cells can trigger cell growth and division, increasing stem-cell state. Squeezing intestinal cells activates specific proteins, leading to larger organoids with more stem cells on their surface.
Researchers at IRB Barcelona have developed a new method to regulate cell plasticity by inhibiting the protein CDK8, strengthening gene expression for specific cell identities while reducing alternative identities. This approach holds promise for improving chemotherapy reactions and studying embryonic stem cells.
Researchers found that placenta cells start to develop shortly after fertilization, triggering a cascade of molecular events. This discovery could lead to improvements in fertility treatments and a better understanding of placental-related diseases during pregnancy.
The segmentation clock, which governs embryonic body pattern formation, progresses more slowly in humans than in mice. Human cells exhibit slower degradation rates and longer transcription/translation times for the HES7 protein.
Researchers at the Francis Crick Institute found the clock that sets the speed of embryonic development, discovering it's based on protein breakdown and replacement. Human motor neurons take twice as long to form as mouse motor neurons due to slower protein turnover.
Researchers have discovered that HSCs from early human embryos can multiply approximately 200-500 times more than those from umbilical cord blood, potentially revolutionizing blood cancer treatment. This breakthrough could lead to advances in expanding HSCs from bone marrow and cord blood, increasing the available blood supply.
Scientists developed three-dimensional heart organoids resembling the developing heart using mouse embryonic stem cells and fibroblast growth factor 4 (FGF4). The organoids exhibit functional properties similar to their in vivo counterparts, offering a promising biomimetic model for studying heart development and testing novel drugs. T...
Researchers successfully regulated parameters to enhance cardiomyocyte production, overcoming limitations of embryoid body differentiation. The use of 3D printing enables precise control over stem cell differentiation, paving the way for bio-inspired approaches in regenerative medicine.
Researchers at the University of Illinois trained light-sensitive neurons using timed pulses of light during early cell development, leading to improved connections, responsivity, and gene expression. The early training resulted in long-lasting improvements, whereas cells trained later had transient responses.
Researchers studied iPS cell-derived heart muscle cells after transplantation to understand the phenomenon of irregular heartbeats. They found that the activity of working-type cells increases significantly, while nodal-like cells decrease in proportion, leading to a reduction in arrhythmia.
Cancer researchers identified a previously unseen cell state that enables tumors to develop resistance to chemotherapy, and found this adaptable cell type in every tumor they examined. This discovery offers hope for developing targeted therapies to combat cancer's adaptability and provide longer-lasting remissions.
Researchers have found that embryonic stem cells use a self-eating process called chaperone-mediated autophagy (CMA) to maintain pluripotency, but switch to a related metabolite when differentiating into specialized cells. This discovery could lead to new regenerative therapies for tissue and organ repair.
Researchers discover a way to 'tune down' heterochromatin in early embryos, improving artificial cell reprogramming efficiency. This knowledge can lead to the efficient generation of high-quality stem cells for regenerative medicine approaches.
A new study investigates the impact of plastic nanoparticles on human development, finding links to eye development, cardiac malformations, and ischemia. The research highlights the need for urgent action to create regulatory measures to lessen NPs' impact on human health.
Researchers have successfully reprogrammed three types of mouse cells into induced hair cell-like cells, offering a potential solution for identifying causes and treatments of hearing loss. The new cells possess characteristics similar to naturally occurring hair cells and are vulnerable to an antibiotic known to cause hearing loss.
Researchers used a 'disease in a dish' stem cell model to examine the mechanism behind retinal ganglion cell degeneration in glaucoma. The study found that cells from individuals with a genetic risk allele for glaucoma were stalled at an immature stage, making them more vulnerable to degeneration.
Researchers developed a new model to study early human development using human embryonic stem cells, allowing them to observe the formation of the body plan and potentially reveal causes of birth defects and diseases. The model, called gastruloids, resembles an embryo at around 18-21 days old.
Two researchers received a prestigious award for their innovative methods in reducing animal use in poultry red mite testing and developing human and mouse embryonic stem cell cultures. Their work has significantly reduced the number of animals used in these fields, paving the way for further improvements in 3Rs research.
A new lab-grown human skin cell model has been developed at Stanford University, allowing researchers to study hair growth and development in greater detail. This breakthrough could potentially provide insights into reversing hair loss and developing new treatments.
Researchers found that the loss of UBE2K enzyme silences key genes for neuronal differentiation, leading to impaired development of nerve cells. The study provides a potential link between epigenetic regulation and neurodevelopmental diseases.
Researchers at Lund University have created a new model that mimics the early developmental stages of the human brain, allowing them to study how different regions form and potentially produce specific neural cells for treatment. The model, called MiSTR, enables faster production of neural cells for neurological diseases.
Researchers create a mouse model that can identify different cell types as they emerge and what genes each is turning on, providing a greater understanding of development, aging and disease. This system uses CRISPR gene editing technology and 'barcoding' to track thousands of cells simultaneously.
Researchers at University at Buffalo have developed a method to produce millions of mature human cells in mouse embryos, which could lead to game-changing stem cell treatments for critical diseases. The technique involves converting human pluripotent stem cells into a form compatible with the inner cell mass inside a mouse blastocyst, ...
A team of researchers at the Francis Crick Institute identified early-commitment genes that trigger irreversible cell specialization in human embryos. These genes, which include GATA3, activate a positive feedback loop, ensuring cells remain differentiated and do not reverse back to a stem cell state.
Researchers at Kyoto University have successfully reconstructed the human segmentation clock using induced pluripotent stem cells (iPSCs), a key focus of embryonic development research. The study reveals novel genetic components and oscillation patterns of the clock, which controls the formation of organs and tissues.
Researchers at Karolinska Institutet have developed a new method to refine the production of retinal cells from embryonic stem cells using CRISPR/Cas9 gene editing. The modified cells can hide from the immune system, reducing the risk of rejection and potentially leading to a new treatment for age-related macular degeneration.