Articles tagged with Embryonic Stem Cells
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Scientists have created a human cell-based model to study the initiation and progression of small cell lung cancer, identifying critical tumor suppressor genes. The new model allows researchers to study the disease at different stages, enabling further studies on treatment strategies.
Researchers have identified a crucial role for the folliculin gene in embryo implantation. A deficiency in this gene can lead to infertility, as cells maintain their pluripotent state and fail to exit the pre-implantation stage. The study also highlights a connection between folliculin mutations and cancer, as well as its potential to ...
Researchers have successfully generated functional, transplantable B cells from mice using mouse embryonic stem cells. The study demonstrates that these cells can secrete natural antibodies and maintain themselves for over six months after transplantation.
Researchers at the Babraham Institute have identified two proteins, Dppa2 and Dppa4, as key factors responsible for activating the zygotic genome. These findings provide valuable insights into the molecular regulation of early development in mammals, shedding light on a previously unexplored area of human development.
A study published in Nature reveals that gut tube formation is driven by collective cell movements of the endoderm, triggered by a molecular gradient converted into a force gradient. This process coordinates cells to form a hollow tube structure crucial for respiratory and gastrointestinal tract development.
Researchers have developed a new method to analyze cardiac muscle cells derived from human pluripotent stem cells, using a non-invasive fluorescence technique that enables faster and more accurate analysis. This breakthrough method uses CRISPR-Cas9 to generate a calcium-indicating reporter stem cell line, which allows for the examinati...
Scientists from the Salk Institute discovered a new protein complex that keeps embryonic stem cells at their fullest potential, allowing them to maintain their indefinite potential. This discovery could provide a future target for regenerative therapies.
Researchers at Michigan State University have identified YAP1 and WWTR1 as crucial proteins in regulating the balance between pluripotent cells and placenta formation. This discovery sheds light on the natural process of creating embryonic stem cells, which could lead to advances in regenerative medicine and organoid technologies.
Rebekah Charney, a postdoctoral researcher at UCR, has been awarded a $177,000 NIH fellowship to study the earliest events underlying neural crest cell formation. The research aims to address key biological questions and potentially lead to novel therapeutics.
A team at Kyoto University has discovered that individual cells sense and modulate themselves to form the spherical shape of the eye through a process called self-bending. This phenomenon generates a hinge that pushes cells into the cup-like structure, resulting in the formation of an optic cup.
Researchers discover that embryonic cells retain a memory of chemical signals they encounter during development. Exposure to WNT and Activin signaling is necessary for differentiation, and cells can remember previous exposure to these signals, even if the signal is absent at the time of treatment.
The discovery of human embryonic stem cells in 1998 revolutionized regenerative medicine, with 29 clinical trials underway globally. The field has grown exponentially, enabling large-scale production of pure cells for research, and nearly $1.43 billion spent on NIH stem cell research over the past 20 years.
A study published in Nature Communications sheds light on how intercellular communication influences the differentiation of embryonic stem cells. Researchers discovered a potential mechanism to control the rate of differentiation without affecting the overall patterning of resulting multicellular tissues.
Scientists successfully grew three-dimensional salivary gland tissue that produced saliva in mice, paving the way for potential treatments for patients with failing organs. The research used embryonic stem cells to create an organoid, a simplified three-dimensional tissue that resembles a real organ.
Researchers at the Gladstone Institutes have developed a new method to study the earliest stages of human development, mimicking how cells self-organize into distinct populations. By silencing specific genes in human pluripotent stem cells, they created ring patterns that influence cell behavior and future identity.
Researchers report on the most in-depth study to date of how human stem cells can be turned into heart cells, revealing unique patterns of gene activity associated with cardiac cell development. The findings provide new insights into how the heart builds itself and may lead to new approaches for repairing damaged hearts.
Researchers have developed artificial pseudo-embryos from mouse stem cells that display characteristics of early embryonic development, including the formation of antero-posterior, dorso-ventral, and medio-lateral axes. These structures, called gastruloids, could complement animal embryos in studying mammalian embryonic development.
The Mek5/Erk5 pathway plays a crucial role in skeletogenesis through the regulation of mesenchymal stem cell differentiation and chondrocyte maturation. Erk5 controls early chondrogenic differentiation and chondrogenic differentiation after condensation formation. This study improves our understanding of skeletal development and paves ...
Researchers found that changing the balance of histone modifications at bivalent promoters has profound effects on gene activity, leading to changes in genome architecture. The study sheds light on the earliest points in development when cells make quick decisions about their fate.
Scientists have developed a method to create human lung organoids from embryonic stem cells, which can develop into mature alveolar type 1 and 2 cells. The study demonstrates the potential for these organoids to model human lung development, providing new insights into the disease.
A new method allows for rapid generation of functional brain cells, known as astrocytes, from embryonic stem cells in just two weeks. This breakthrough enables researchers to study the role of astrocytes in various diseases, including neurodegenerative conditions such as dementia and ALS.
Researchers at Salk Institute identify genetic features of human basal-like breast cancers that share similarities with embryonic mammary stem cells, which may be targeted therapeutically. The study provides insights into how cancer cells gain plasticity and become resistant to therapies.
UNIGE researchers found that bioelectrical potential is a driving force for stem cells to generate different types of neurons during embryogenesis. This discovery reveals an unexpected role for electrical charge in generating neuronal diversity, which could help explain how neurological disorders affect brain development.
Scientists at the University of Cambridge have successfully generated key life event in artificial mouse embryo created from stem cells. The team used three types of stem cells to reconstruct the process of gastrulation, a crucial step in embryonic development.
Researchers have created a two-pronged approach to cloning mice by stimulating two epigenetic factors, improving efficiency and uncovering key mechanisms. This breakthrough overcomes significant hurdles in the development of cloned animals.
Researchers at NUS have successfully reprogrammed mature cells into pluripotent stem cells by confining them in a defined geometric space for an extended period. By the 10th day, the cells expressed genes associated with embryonic stem cells and iPSCs, indicating complete transition into re-deployable stem cells.
Researchers at the University of Helsinki have developed a new method for turning skin cells into pluripotent stem cells by activating the cell's own genes, eliminating the need for artificial gene introduction. This breakthrough enables efficient and physiological cellular reprogramming using CRISPRa technology.
An international team of scientists has successfully created a hybrid embryo from Southern White Rhino eggs and Northern White Rhino sperm using assisted reproduction techniques. The breakthrough is published in Nature Communications today, offering hope for the survival of the endangered species.
A new study in mice reveals that a 'jumping gene' plays a critical role in the first stages of embryonic development. High levels of LINE1 RNA expression are necessary to regulate gene activity and enable embryos to progress past the two-cell phase.
EMBL researchers used optogenetics to reconstruct epithelial folding in cells that normally don't undergo the process. This allowed them to build tissues in customized shapes without affecting cell function. The technique has implications for regenerative medicine and ex vivo stem cell culture systems.
Researchers at Stowers Institute for Medical Research have isolated a regenerative cell capable of regrowing entire organisms. By combining genomics, single-cell analysis, flow cytometry, and imaging techniques, they targeted the elusive cell, which is a subtype of adult pluripotent stem cells, to discover its secrets.
Researchers from Newcastle University discovered that human embryonic stem cells travel back and forth in a line, revealing subtle patterns to their movement. This finding has important implications for the development of computer models to predict and control stem cell evolution.
A team of Rockefeller scientists has discovered the molecular signals that direct cell differentiation in human embryos, shedding light on the earliest stages of development. The findings have implications for regenerative medicine and could lead to new treatments for diseases such as cancer and diabetes.
A new study by Brigham and Women's Hospital researchers reveals how HIV establishes a persistent reservoir of infected cells that can survive indefinitely. The findings highlight the role of BIRC5 and OX40 in these cells' long-term survival, providing potential targets for future therapy.
The study identifies embryonic mammary gland progenitors as multipotent cells that can give rise to both basal and luminal lineages. The researchers developed a novel strategy to isolate these cells and assessed their molecular features, revealing a hybrid transcriptional signature.
Researchers at Oregon State University have identified a multifaceted stem cell niche that gives rise to neurons, blood vessels, blood cells and immune cells. This breakthrough could lead to the growth of entire organs in a laboratory setting.
Researchers have developed a technique to quantify 3D forces within cells using elastic microspheres filled with fluorescent nanoparticles. The study found that these mechanical forces play a fundamental role in cell physiology and may help unlock mysteries related to embryonic development and cancer stem cells.
Tissue-engineered human pancreatic islets developed a circulatory system and secreted hormones like insulin, resolving the disease in transplanted mice. The self-condensation cell culture process promotes vascularization, offering a potential curative strategy for type 1 diabetes.
Researchers have developed a system to profile every cell in developing zebrafish and frog embryos, revealing the comprehensive landscape of gene expression events that mark new cell states and types. This work provides a significant resource for studying developmental biology and disease.
A new study has identified a critical stage in human embryonic development that may contribute to infertility and miscarriage. The research, led by UCLA biologist Amander Clark, reveals that epigenomic changes in early embryonic stem cells play a crucial role in determining embryo viability.
A new review concludes that stem cells derived from adult body tissues can differentiate into mature body cells with similar efficiency to those from younger donors. This validates induced pluripotent stem cells (iPSCs) as a viable alternative to embryonic stem cells in regenerative medicine.
Researchers generated an atlas of the human genome using human embryonic stem cells, identifying essential genes for growth and survival. The study also analyzed the role of cancer-causing genes in early development and growth.
Male and female cells behave differently after being reprogrammed into stem cells due to their number of X chromosomes. This affects DNA methylation, a process that changes DNA activity without changing its sequence.
Researchers at Gladstone Institutes have uncovered the role of MYC and LIN41 in reprogramming cells. They found that MYC helps cells overcome a roadblock, while LIN41 blocks another protein that causes the roadblock, allowing adult cells to successfully convert into induced pluripotent stem cells.
Researchers have discovered a balance between two sets of transcription factors that instruct blood vessel cells to become blood stem cells during embryonic development. The findings could aid research into creating new blood cells for transplants and understanding cancer metastasis.
Babies' movement in the womb is crucial for developing strong bones and joints. Research has identified that cells receive incorrect molecular signals when movement is absent, leading to brittle bones or abnormal joints. Understanding this mechanism can lead to improved treatments for joint injuries and diseases.
Human embryonic stem cells are immortal due to a 'garbage disposal system' called the proteasome. Reducing E3-ubiquitin ligases levels does not affect their behavior, but impacts overall cell function.
Researchers at the Wellcome Sanger Institute discovered that SMAD2/3 proteins coordinate unexpected pathways with finely tuned gene expression, allowing cells to switch on and off genes rapidly. This mechanism could be essential for rapid responses in other processes like organ repair or cancer growth.
Researchers discovered that most new cardiomyocytes come from cardiac progenitor cells during early embryonic development, but this ability fades as mice mature. The study's findings could lead to methods for regenerating heart tissue after a heart attack.
Researchers have developed a human intestinal lining that mirrors living tissue when placed inside microengineered Intestine-Chips. This breakthrough enables personalized testing of drug treatments for debilitating gastrointestinal diseases such as Crohn's disease and ulcerative colitis.
Researchers have created a new mapping app to track stem cells, allowing for the analysis of cell behavior, function, and changes over time. The Web Image Processing Pipeline (WIPP) system uses video footage and high-power computation to bring cell populations under evaluation.
Researchers at UC Davis develop a culture system that efficiently derives embryonic stem cells from cattle on nearly every attempt. This breakthrough could revolutionize the way genetics is done by orders of magnitude, enabling faster breeding of genetically superior cows with desirable traits.
Scientists at Rockefeller University discovered early abnormalities in human embryonic stem cells with Huntington's disease, suggesting the disorder originates much earlier than previously thought. The study implies that existing treatments may do more harm than good and necessitates a new approach to treating the disease.
Researchers at Tohoku University have successfully cultured human placenta stem cells for the first time, opening up new avenues for studying fetal development and maternal health. The study, led by Takahiro Arima, has shed light on the crucial role of trophoblast cells in supporting fetal growth and development.
Researchers at the Salk Institute have found a streamlined method to generate functioning heart cells from embryonic stem cells by turning off a single gene, YAP. This discovery offers scientists a simpler protocol for creating cardiomyocytes for research and regenerative therapies.
Researchers at Helmholtz Munich have discovered a specific subset of pluripotent embryonic stem cells that can transform into totipotent-like cells in culture. This breakthrough could pave the way for new treatments and therapies for various diseases, including diabetes and lung conditions.
A Japanese research group develops a method to induce ureteric buds from pluripotent stem cells and successfully reproduces the higher-order structure of the kidney. This achievement is a significant step towards regenerating functional kidneys, which could potentially treat millions of patients with chronic kidney disease.
An international team of researchers identified a specific mechanism leading to Zika virus-associated microcephaly, involving protein misfolding and endoplasmic reticulum stress. This triggers the unfolded protein response, promoting apoptosis in neuronal cells and reducing cortical neuron development.
A series of studies by Monash University researcher Jose Polo have unveiled new evidence in the decade-long mystery of cell reprogramming. The researchers found that the route to pluripotency depended on the original cell type, with different cell types requiring different approaches. This breakthrough has important implications for re...
Researchers discovered that inhibiting two forms of GSK3 can promote stem cell self-renewal or trigger differentiation into neural cells. The findings have implications for developing targeted therapies for diseases such as diabetes and Alzheimer's, and could lead to the production of human stem cells with specific properties.