Articles tagged with Embryonic Stem Cells
Researchers have discovered that TET proteins, which modify methyl groups attached to cytosine, influence gene expression and facilitate the removal of these marks. This dynamic modulation is critical for driving developmental gene expression programs in early embryos, particularly in neural tissue formation.
Researchers at Helmholtz Zentrum München found a mechanism controlling cell division after fertilization, allowing for diverse cellular development. The study reveals that the molecule Suv4-20h2 attaches methyl groups to histones, arresting cell progression and enabling totipotency.
Researchers at the Babraham Institute used CRISPR to delete PRC2 from human embryonic stem cells, revealing its role in keeping genes switched off until needed. Loss of PRC2 caused compromised cell quality and specialisation into mature cell types.
Scientists at UCSB developed a powerful new technique to measure the mechanical properties of cells in living tissues, shedding light on how cells respond to biochemical and mechanical cues. The method reveals that cells perceive their natural habitat as a fluid-like environment, with varying stiffness and viscosity along the body axis.
Scientists found that a balance of telomere elongation and trimming in stem cells is necessary for optimal telomere length. Over-elongated telomeres accumulate DNA damage and can lead to cancer. The study deepens understanding of stem cell biology and has implications for regenerative medicine and aging research.
Researchers found that more Nanog protein in cells leads to less reproduction, contradicting previous assumptions. The study uses an algorithm called STILT to analyze time-resolved protein expression data, revealing a negative feedback loop that regulates Nanog's activity.
Researchers at Karolinska Institutet have measured the absolute numbers of short, non-coding, RNA sequences in individual embryonic stem cells, revealing their precise function. The new method could lead to improved IVF treatments by identifying embryos with the best chance of development.
Researchers discovered vitamins A and C enhance epigenetic memory erasure by increasing TET enzyme activity, a crucial step for regenerative medicine. The study provides insights into the mechanisms of vitamin A and C action, with potential implications for treating vitamin A-resistant acute promyelocytic leukemia.
A new study from the University of California, Berkeley, reveals that calcium plays a major role in regulating bone growth and development. By understanding the signaling mechanisms involved, researchers hope to develop regenerative therapies for conditions such as Treacher Collins Syndrome, which can lead to dozens of surgeries during...
A recent study found that genomic imprinting, a process silencing one set of parental genes, can be regulated in adult tissues. The researchers observed variation in epigenetic marks between cell types, indicating a need for fine-tuned gene expression in different tissues throughout development and adulthood.
A University of Tsukuba-led research group has identified Pax6 as the protein regulator of retinal regeneration in newts. This discovery could lead to a new treatment approach for retinal problems, enabling the regeneration of damaged retinas.
Scientists in Japan have successfully demonstrated the transplantation of stem cell-derived retinal cells generated from immunologically matched donor animals without the need for harmful immunosuppressants. MHC-mismatched grafts produced tissue damage and signs of immune rejection, while matched grafts survived without immunosuppression.
Salk Institute scientists have discovered a method to create unlimited numbers of precursor kidney cells using a three-dimensional culture and new supporting molecules. These early-stage kidney cells could be used to grow replacement kidney tissue for studying and treating diseases.
Researchers developed a new biomaterial to examine how stem cells perceive their environment's mechanical properties. The study found that manipulating this perception could control stem cell differentiation and promote regenerative therapies for musculoskeletal disorders.
A new study reveals that human stem cells have pluripotency superior to some types of mouse-derived cells. Researchers mapped gene expression patterns in crab-eating monkeys to understand the developmental counterparts of primate stem cells.
Researchers found a molecular switch that flips between different versions of genes, enabling stem cells to regenerate and differentiate across all animals. This discovery suggests an ancient mechanism critical for animal stem cell properties.
Researchers identify citron kinase as key to building a normally sized human brain, finding mutations associated with severe microcephaly and lissencephaly. Studying stem cells and human brain tissue provides clues to the condition's origins, paving the way for further research into its causes.
Researchers discovered that introducing the embryonic gene Nanog into aged stem cells can reverse cellular processes associated with age-related disorders, such as weak bones and clogged arteries. This breakthrough could lead to new treatments for conditions like Alzheimer's disease.
Researchers developed a method to revert and maintain human ESCs in a naive state, closely resembling that of mouse ESCs. The team assembled a checklist of characteristics human ESCs must have to be considered naive, including gene expression, DNA methylation, and X chromosome inactivation.
Scientists have created a four-step process to determine accurate signatures of human embryonic stem cells, relating them to precise developmental stages. The key steps involve analyzing transposable elements and DNA methylation state to assess pluripotency.
Researchers at Stanford University School of Medicine have mapped out biological signals necessary to direct human embryonic stem cells to become pure populations of bone, heart muscle, and cartilage. The ability to generate these cell types quickly is a key step toward regenerative medicine.
Scientists developed guidelines to evaluate laboratory-generated stem cells, finding that no current methods produce truly naïve embryonic cells. The new criteria may aid researchers in achieving this goal, which could benefit both basic research and medical applications of stem cells.
Researchers have created an atlas of gene expression during early mammalian development using single-cell sequencing. This new tool allows for direct observations of individual cells, enabling scientists to map healthy cells against those with genetic abnormalities, shedding light on the causes of birth defects.
Researchers have discovered a technique to improve the function of engineered organs and tissues by starving stem cells of glutamine, leading to more mature and functional endothelial cells. This method may prove useful for tissue engineering, particularly in the creation of functional blood vessels from human embryonic stem cells.
Researchers found that glucosamine plays a critical role in early embryonic development, helping embryos proliferate normally. This could aid in avoiding birth defects in diabetic pregnancies and improving future stem-cell treatments. Glucosamine is also essential for embryonic cells to grow and develop.
Scientists discovered a unique tumour-suppressor gene, alternative reading frame (ARF), that remains active in naked mole rat induced pluripotent stem cells. Reprogramming these cells into human-like iPSCs may lead to safer cell-based therapeutics by avoiding tumour formation.
Researchers at Johns Hopkins Medicine have successfully grown lab-grown human nerve cells that can partner with heart muscle cells to stimulate contractions. The nerve cells, derived from pluripotent stem cells, were found to connect with and control heart muscle cells, similar to their natural counterparts.
Researchers found that Prkci gene plays a crucial role in organizing cells into balls and tubes during early embryo and organ formation. By mixing functional Prkci with cells lacking it, they restored normal polarity, suggesting an unknown molecular signal was transmitted to disoriented cells.
Researchers have concluded that reprogramming does not create differences between reprogrammed and embryonic stem cells. A thorough study showed that reprogrammed and embryonic stem cells are similar, with a list of 275 key genes that can present reprogramming results.
Human parthenogenetic stem cells derived from unfertilized oocytes can be used to generate unlimited supply of neural stem cells for transplantation. The study found that grafting these cells into non-human primates with Parkinson's disease promoted behavioral recovery and increased dopamine concentrations.
Researchers at CNIO have developed a new method to create mice with hyper-long telomeres using epigenetic changes, avoiding genetic manipulation. This technique results in fewer signs of molecular aging and a lower incidence of cancer in the mice.
A team of biologists at New York University found that plants can reconstitute their stem cells from mature cells by replaying embryonic development. This process involves the recruitment of specialized cells to create a new set of stem cells, highlighting the importance of tissue behavior over stem cell properties.
Researchers at the University of Sheffield have identified a protein called Syncytin-1, which helps embryos implant in the womb, potentially improving treatments for recurrent miscarriages and pre-eclampsia. The discovery sheds light on fundamental stages of human embryo development.
Researchers at the University of Pennsylvania have discovered that lab-made stem cells often retain errors in DNA folding, leading to incomplete differentiation into adult cells. The team suggests ways to minimize these errors and has developed high-resolution maps of genome folding in iPS cells.
Researchers have identified a long non-coding RNA in the placenta that plays a crucial role in protecting the unborn baby from invading pathogens. The lncRNA, called lncRHOXF1, regulates the immune response and appears to be sensing and modulating its expression based on the presence of viruses.
Scientists have developed a novel technique to study human embryo implantation, allowing for the first time to observe molecular and cellular processes up to day 14 after fertilization. This breakthrough expands understanding of human development and may shed light on early miscarriages and infertility causes.
Brown University bioengineers have developed a synthetic bed that works as well as traditional mouse cells without contamination risk. The innovation allows for the cultivation of human embryonic stem cells more safely and could lead to advances in stem cell therapies.
A new literature review assesses the benefits of stem cells for treating spinal cord injuries. Different types of stem cells show varying degrees of effectiveness in restoring function, and an ideal treatment protocol remains unclear.
Research found that heterochromatin organisation in embryonic stem cells is maintained in an open form through the action of key stem cell factors. This open architecture may contribute to keeping stem cells unspecialised and full of developmental potential.
A University of Wisconsin-Madison neuroscientist has successfully inserted a genetic switch into nerve cells to regulate dopamine production with designer drugs. This breakthrough could lead to the development of a new Parkinson's disease treatment and expand its application to other conditions.
Researchers at the Salk Institute found that a protein complex called AMPK plays a critical role in monitoring and managing cells' energy processes during development. The discovery sheds new light on cancer and diabetes pathways, offering potential insights into stem cell therapies and cancer treatments.
Researchers at Gladstone Institutes develop a new method to create three-dimensional human heart tissue from stem cells, addressing limitations of existing techniques. This breakthrough enables scientists to study heart cells in their proper context, enhancing the discovery of treatments for heart disease.
Researchers have made significant discoveries about early human embryo development, finding that genes on the X chromosome are regulated differently in humans than in mice. This new understanding is crucial for the use of embryonic stem cells in regenerative medicine.
Researchers successfully grew skin tissue with hair follicles and sebaceous glands in the laboratory using reprogrammed iPS cells. The tissues formed normal connections with surrounding nerves and muscle fibers, paving the way for potential functional skin transplants.
Scientists at the University of Cambridge and EMBL-EBI discovered that four-cell embryo cells exhibit subtle genetic differences, indicating that early development is guided by specific decisions. The study used sequencing technologies to model embryo development, revealing distinct gene expression patterns in individual cells.
Researchers have developed a drug that can erase epigenetic markers on chromatin to restore the original state of stem cells in mice. The study shows that over half of mouse epiblast stem cells treated with the drug regained embryonic pluripotency, opening up new possibilities for regenerative medicine.
Researchers at The Hebrew University of Jerusalem have successfully generated a new type of embryonic stem cell carrying a single copy of the human genome. These haploid stem cells are pluripotent and retain a single set of chromosomes, offering a powerful tool for genetic analysis and potential therapies for diseases.
Researchers at Columbia University Irving Medical Center have successfully generated a new type of human embryonic stem cell carrying a single copy of the human genome. These 'haploid' stem cells show potential as a powerful tool for genetic analysis in biomedical fields such as cancer research and precision medicine.
Researchers Qi-Long Ying and Austin Smith won the 2016 McEwen Award for Innovation for their discovery of inhibitory molecules that can mimic embryonic stem cells' ability to generate different cell types. Their work has opened new avenues of exploration towards understanding or treating human disease.
Researchers at Mount Sinai identified precursor cells in mice embryos that can be matured into hematopoietic stem/progenitor cells (HSPCs) using reprogramming technology. This breakthrough could lead to the development of patient-specific HSPCs for cell-replacement therapy and alleviate the need for transplantable stem cells.
Researchers at the University of Cambridge have successfully derived naïve pluripotent stem cells from human embryos, which can develop into all human tissue types. This breakthrough has significant implications for regenerative medicine and modeling human disorders, including Down's syndrome.
Scientists at Gladstone Institutes discover a new type of cell that can organically develop into heart cells and replicate. The induced expandable cardiovascular progenitor cells (ieCPCs) significantly improved heart function in mice after a heart attack, offering a promising potential treatment for heart failure.
Researchers at Michigan State University have discovered a new type of induced Xen (iXEN) stem cells that can be created by reprogramming mature adult cells. These cells have unique properties and can shed light on reproductive diseases, potentially leading to advances in regenerative medicine.
Researchers successfully generated functioning sperm-like cells from mouse embryonic stem cells and produced fertile offspring, providing a potential platform for treating male infertility. The breakthrough overcomes major obstacles to producing functional sperm and egg cells in a dish.
Researchers at the University of Birmingham have identified key regulators of blood cell development using a 'big data' approach. By studying six consecutive stages of development, they discovered previous unknown regulators and explained how regulatory elements work together to drive gene expression and stage transitions.
Scientists have discovered that deactivating the MYC oncogene can induce a dormant state in embryonic stem cells, similar to diapause, allowing them to survive without growth or metabolism. This finding has implications for controlling cancer stem cells and metastasis.
Researchers have developed a method to halt stem cell growth using soft hydrogels that mimic the natural protective layer of mucus. This process, inspired by embryonic diapause in certain mammals, allows for easy storage and shipment of stem cells.
A new study provides a reliable method to generate neural crest cells in just five days from human embryonic stem cells or induced pluripotent cells. The research highlights the critical role of WNT signals, FGF and BMP pathways, and sheds light on the initiation of neural crest cell formation.
Researchers at the University of Bath have developed a method to detect and preserve human pluripotent stem cells in the laboratory. This breakthrough allows for easier acquisition and cultivation of these rare cells, which can potentially be used to develop pioneering treatments for various diseases.
A team of scientists at UCL has discovered a way to fast-track the screening of induced pluripotent stem cells (iPSCs) using DNA methylation as a biomarker. This new approach can help identify 'good' and 'bad' cell lines, which is crucial for laboratory research and potential cell replacement therapies.