Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. The research team from the Sixth People's Hospital Affliated to Shanghai Jiao Tong University, Shanghai, China and Zhoupu Hospital, Pudong New District, Shanghai, China, led by Prof. Xiaojiang Sun and Prof. Kangyong Liu summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects. The relevant article is reported in the Neural Regeneration Research (Vol. 9, No. 12, 2014).
Article: "Autophagy: a double-edged sword for neuronal survival after cerebral ischemia" by Wenqi Chen1, Yinyi Sun1, Kangyong Liu2, Xiaojiang Sun1 (1 Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China; 2 Zhoupu Hospital, Pudong New District, Shanghai, China) Chen WQ, Sun YY, Liu KY, Sun XJ. Autophagy: a double-edged sword for neuronal survival after cerebral ischemia. Neural Regen Res. 2014;9(12):1210-1216.
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