Miami (April 29, 2025) – Increased perceived stress may cause worsened respiratory symptoms and decreased quality of life in people with chronic obstructive pulmonary disease (COPD), according to a new study. The study is published in the March 2025 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation , a peer-reviewed, open-access journal.
Perceived stress is used to describe how overwhelmed or stressed a person feels based on their personal understanding of the situation. It is a psychosocial factor, along with loneliness, social isolation and emotional support, which have been shown to impact health outcomes in people with chronic diseases.
COPD is an inflammatory lung disease, comprising several conditions, including chronic bronchitis and emphysema, and can be caused by genetics and irritants like smoke or pollution. The disease affects more than 30 million Americans and is the fourth leading cause of death worldwide.
This new study evaluated data from the Comparing Urban and Rural Effects of Poverty on COPD (CURE COPD) study, which examined how obesity, poor diet and indoor air quality impact former smokers with COPD living in low-income, urban areas. The authors examined the association between perceived stress on respiratory health and on platelet activation, oxidative stress and systemic inflammation—biological processes which may contribute to COPD.
“There is increased evidence that psychosocial factors, including perceived stress, are associated with worsened respiratory symptoms for people with COPD. Platelet activation, which may contribute to inflammation, and oxidative stress, which may lead to cell and tissue damage, are also impacted by increased perceived stress,” said Obiageli Lynda Offor, M.D., MPH, a Pulmonary and Critical Care Fellow at Johns Hopkins Medicine in Baltimore, and lead author of the study. “While our study examined a small group of patients, our results demonstrate the need for further research on how perceived stress impacts respiratory health and the importance of addressing psychosocial factors to help improve people’s quality of life.”
To access current and past issues of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation , visit journal.copdfoundation.org .
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About the COPD Foundation
The COPD Foundation is a nonprofit organization whose mission is to help millions of people live longer and healthier lives by advancing research, advocacy, and awareness to stop COPD, bronchiectasis, and NTM lung disease. The Foundation does this through scientific research, education, advocacy, and awareness to prevent disease, slow progression, and find a cure. For more information, visit copdfoundation.org , or follow us on Twitter and LinkedIn .
Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation
Observational study
Perceived Stress is Associated With Health Outcomes, Platelet Activation, and Oxidative Stress in COPD
11-Feb-2025
NP reports reimbursement for participation in advisory boards for Verona and AstraZeneca, both unrelated to the work published. NP reports funding from the National Institutes of Health (NIH)/ National Institute of Environmental Health, and the NIH/National Institute of Allergy and Infectious Diseases, both also unrelated to the work. All other authors have no financial relationships or conflicts of interest related to the submitted work.