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Identification of autophagy gene regulation mechanism related to dementia and Lou Gehrig's disease

07.18.19 | Korea Brain Research Institute

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Figure 1
If the TDP-43 protein expression is inhibited in neurons or muscle cells, then autophagy related genes are affected. Credit: @ Korea brain Research Institute

Korea Brain Research Institute (KBRI, President Seo Pan-ghill) announced on July 10 that the international joint research team where Senior Researcher Jeong Yoon-ha and John Hopkins School of Medicine collaborated, found that 'cell autophagy* gene' called ATG7 is related to the onset of frontotemporal dementia and Lou Gehrig's disease.

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Autophagy

10.1080/15548627.2019.1635379

Additional Media

Figure 3
After inhibiting TDP-43 protein expression in the motor neurons of a mouse, the symptoms of neural degeneration are observed as the mouse grows older. Credit: @ Korea Brain Research Institute
Figure 2
After inhibiting TDP-43 protein expression in the motor neurons of a mouse, the symptoms of ataxia are observed as the mouse grows older. Credit: @ Korea brain Research Institute

Keywords

Autophagy Dementia Gene Regulation

Article Information

Journal
Autophagy
DOI
10.1080/15548627.2019.1635379

Contact Information

Jeong Yoonha
yunha.jeong@kbri.re.kr

How to Cite This Article

APA:
Korea Brain Research Institute. (2019, July 18). Identification of autophagy gene regulation mechanism related to dementia and Lou Gehrig's disease. Brightsurf News. https://www.brightsurf.com/news/LD576MNL/identification-of-autophagy-gene-regulation-mechanism-related-to-dementia-and-lou-gehrigs-disease.html
MLA:
"Identification of autophagy gene regulation mechanism related to dementia and Lou Gehrig's disease." Brightsurf News, Jul. 18 2019, https://www.brightsurf.com/news/LD576MNL/identification-of-autophagy-gene-regulation-mechanism-related-to-dementia-and-lou-gehrigs-disease.html.