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Protective effects of coffee in Parkinson's disease models

12.03.18 | Proceedings of the National Academy of Sciences

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Mice
Normal mice (left) shred a pressed cotton square and arrange the material to build a nest. Nesting behavior is impaired (center) following injection of alpha-synuclein fibrils into the striatum (the part of the brain where dopamine producing neurons project to), but this behavior is preserved in fibrilinjected mice co-treated with EHT and caffeine (right). Credit: Image courtesy of M. Maral Mouradian

A study of mouse models of Parkinson's disease (PD) and dementia with Lewy bodies finds that the coffee component eicosanoyl-5-hydroxytryptamide acts synergistically with caffeine, which was previously thought to be the neuroprotective component of coffee, to maintain the enzyme PP2A in an active state so that the enzyme can dephosphorylate pathogenic hyperphosphorylated α-synuclein proteins, implicated in PD; the two compounds may together prevent neurodegeneration and neuroinflammation and protect brain cells, according to the authors.

Article #18-13365: "Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB," by Run Yan et al.

MEDIA CONTACT: M. Maral Mouradian, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ; tel: 732-235-4772; e-mail: m.mouradian@rutgers.edu

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Proceedings of the National Academy of Sciences

Additional Media

Hippocampus Immunoreactivity
Hippocampus immunoreactivity, a marker of neuronal activity, (normal pattern, left) is reduced in mice over-expressing alpha- synuclein in the brain (center), but this marker is preserved in overexpressing mice co-treated with EHT and caffeine (right). Credit: Image courtesy of M. Maral Mouradian

Keywords

Coffee Enzymes Parkinsons Disease

Article Information

Journal
Proceedings of the National Academy of Sciences

Contact Information

M. Maral Mouradian
m.mouradian@rutgers.edu

How to Cite This Article

APA:
Proceedings of the National Academy of Sciences. (2018, December 3). Protective effects of coffee in Parkinson's disease models. Brightsurf News. https://www.brightsurf.com/news/LD5N5OXL/protective-effects-of-coffee-in-parkinsons-disease-models.html
MLA:
"Protective effects of coffee in Parkinson's disease models." Brightsurf News, Dec. 3 2018, https://www.brightsurf.com/news/LD5N5OXL/protective-effects-of-coffee-in-parkinsons-disease-models.html.