Washington, DC / Bangalore, India – Globally, during the first two years of the COVID-19 pandemic, antibiotics were prescribed to 75 percent of COVID-19 patients despite bacterial coinfection rates averaging less than 10 percent. Unnecessary use of antibiotics potentially aggravates antimicrobial resistance (AMR), which happens as pathogens, such as bacteria, evolve over time and stop responding to medicines, making infections tough to treat and raising the risk of disease spread, serious illness, and death. To understand this relationship in the context of COVID-19 treatment, OHT researchers and collaborators reviewed associations of COVID-19 cases and immunizations with global antibiotic sales from March 2020 to May 2022.
Researchers affiliated with the One Health Trust , the Population Council, GlaxoSmithKline, and the Harvard T.H. Chan School of Public Health, sourced monthly data on broad-spectrum antibiotic sales volumes (cephalosporins, penicillins, macrolides, and tetracyclines) in 71 countries from the IQVIA MIDAS database. These data were integrated with Our World in Data's country-month-level COVID-19 case and vaccination data. To evaluate the relationships between antibiotic sales volumes and COVID-19 cases and vaccines per 1,000 individuals, researchers utilized least squares and fixed-effects panel data regression models, accounting for country level factors. To our knowledge, this is the first multi-country study to examine clinical and community antibiotic use during the pandemic. The study funded by the Bill and Melinda Gates Foundation is out in eClinicalMedicine.
The study shows that during 2020–2022, antibiotic sales increased along with increases in COVID-19 cases worldwide despite decreases in other common infections that would necessitate the use of antibiotics. The findings indicate the need for antibiotic stewardship in the context for COVID-19 treatment.
Overall, this study found:
According to study co-author, Dr. Arindam Nandi, a Visiting Fellow at the One Health Trust and a researcher at the Population Council, “In a major setback to the global efforts for tackling AMR, billions of excess antibiotic doses may have been prescribed and consumed during the pandemic. The time to act is now.”
‘ Global antibiotic use during the COVID-19 pandemic: analysis of pharmaceutical sales data from 71 countries, 2020–2022’ is published in eClinicalMedicine and is available for download here .
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About the One Health Trust
Tackling today’s greatest challenges—whether climate change, pandemics, or drug resistance—requires an approach that recognizes the interactions among the environment, animals, and humans. The One Health Trust (OHT) employs interdisciplinary expertise to address issues related to infectious diseases, climate change, biodiversity protection, and the effect of changing human diets on the planet.
OHT is the successor to the Center for Disease Dynamics, Economics & Policy (CDDEP), which since 2010 has conducted actionable research on major global health challenges like antimicrobial resistance, malaria, pandemic response, vaccination coverage, and noncommunicable diseases. Expanding on CDDEP’s innovative approaches, OHT’s experts—economists, epidemiologists, modelers, clinicians, statisticians—conduct actionable, policy-oriented research to improve health and well-being worldwide.
EClinicalMedicine
Data/statistical analysis
Global antibiotic use during the COVID-19 pandemic: analysis of pharmaceutical sales data from 71 countries, 2020–2022
5-Feb-2023