Articles tagged with Antibiotic Resistance
Researchers explored how AI and metabolic modeling can inform effective biocontrol strategies to combat antimicrobial resistance in built environments. Microbial biocontrol using 'good' microbes has shown promise, but inconsistent outcomes are due to various factors, including genetic differences and environmental stressors.
A study by Boston University researchers found that CARB-X-backed projects are nearly five times more likely to advance to clinical trials, while nonfunded projects had less than a quarter advancing. The nonprofit's support led to the award of 160 patents and increased odds of life-saving products reaching patients.
The DZIF-supported project PROTON aims to develop innovative agents against Staphylococcus aureus, a bacterial pathogen responsible for severe lung infections. The active agent, a pathoblocker, targets the toxin that destroys lung tissue and immune cells, reducing antibiotic resistance.
Scientists at Scripps Research have found that disabling a specific bacterial enzyme called SagA can restore the effect of vancomycin against resistant bacteria, making them treatable without needing a new antibiotic. This approach targets basic aspects of bacterial physiology and could overcome antibiotic resistance.
A new study forecasts global antimicrobial resistance threats for the next two decades, identifying 210 traits that could pose the greatest future risk. The research uses machine learning and forecasting to predict which genetic factors will become more prevalent and which may decline over time.
Scientists discovered a new antibiotic called manikomycin that binds to the ribosome, halting protein synthesis and blocking an important molecule from exiting. This action makes it harder for bacteria to develop resistance, as they need to jump through hoops to find resistance.
A study analyzing nearly 2,000 human infections with Shiga-producing E. coli found increasing resistance to antibiotics, particularly for tetracycline and sulfisoxazole. The researchers propose a 'One Health' approach to address the issue, focusing on antibiotic stewardship in agriculture, food safety, and environmental controls.
A modified culture medium can quickly and affordably detect fidaxomicin resistance in C. difficile infections, saving 201 hours of work and $9,075 per 1,000 patients screened. The new method correctly identifies resistant isolates with 100% sensitivity.
A new study found that sewage overflows in homes can introduce antibiotic-resistant and multidrug-resistant bacteria, making infections difficult to treat. The research collected samples from 86 Maryland homes and found nearly half had E. enterococci present, with over a third harboring antibiotic-resistant strains.
The center will develop new phage-based treatments for antibiotic-resistant bacterial infections, predicting which phage to use for which patient and designing more effective phages. The goal is to generate unprecedented data and train AI models to identify the right phage for any patient's infection.
Researchers highlight the promise of using human monoclonal antibodies to treat patients more effectively and tackle antimicrobial resistance. mAbs can be designed to target only the disease-causing bacteria, thereby protecting the microbiome.
Europe's bacterial STI cases reached record highs in 2024, driven by gonorrhoea and syphilis, with men who have sex with men disproportionately affected. The near doubling of congenital syphilis cases highlights the need for improved antenatal screening protocols to prevent transmission to newborns.
Researchers at Umeå University have developed new compounds that disrupt bacterial cell membranes and kill dormant cells, offering a promising alternative to existing antibiotics. The discovery is particularly effective against persister cells, which can survive antibiotic treatment and cause relapse of infections.
Researchers engineer bacterial vesicles into multifunctional tools that can kill pathogens, boost vaccines, and deliver targeted therapies. Engineered BEVs address key limitations of existing therapies, including improving vaccine responses and antibiotic delivery.
Researchers used AI to design new molecules for disinfectants, leveraging a dataset of hundreds of existing quaternary ammonium compounds. The approach yielded 11 promising compounds with activity against antimicrobial-resistant bacteria, offering a potential solution to the growing threat of 'superbugs'.
A recent study found that cranberry juice enhanced the antibiotic activity of fosfomycin against 72% of uropathogenic E. coli strains, while suppressing resistance-related mutations. The findings suggest that natural compounds in cranberry juice may be a useful frontier in fighting antibiotic resistance.
The article warns that AI's rapid integration may stifle scientific creativity and innovation, diverting resources away from solving fundamental problems. Dr. Shim argues for preserving human-centered pathways for knowledge generation to ensure diverse thought necessary for breakthroughs.
A new study reveals that bacteria can actively limit the spread of antibiotic resistance genes by deploying molecular gatekeepers called YokF. This mechanism blocks the transfer of beneficial genes, giving microbes a competitive advantage in dense microbial communities.
Researchers have developed a universal toolkit for editing bacterial DNA in 15 diverse species, including human pathogens and fast-growing biotechnology organisms. The technology uses retrons, an immune system that produces DNA, to efficiently modify genes, with varying success rates across different species.
A recent study found that antibiotic-resistant bacteria are present in the gut microbiomes of American black bears in eastern North Carolina. The researchers also discovered that these pathogens can be dispersed through bear feces, making the bears a potential indicator species for environmental changes.
New findings render antibiotic-resistant bacteria vulnerable by disabling individual resistance and cross-protection. This approach offers new possibilities for treating resistant infections associated with cystic fibrosis and may inform the treatment of a broad range of antibiotic-resistant infections.
A major multi-country study found that WHO-recommended first-line antibiotics for neonatal sepsis are effective in only one quarter of infections in low- and middle-income countries. High levels of antimicrobial resistance were observed, making it challenging to identify consistently effective empirical antibiotic regimens.
A study analyzing meconium samples from newborns found high prevalence of antibiotic resistance genes, including those linked to carbapenem resistance. The findings suggest that maternal transmissions and early hospital exposure contribute to the establishment of these genes in the neonatal gut.
Researchers discovered highly antibiotic-resistant bacteria in wildlife samples, including foxes and birds, indicating potential early warning system for AMR spread. The study highlights the need for environmental interventions to prevent resistance from reaching clinical settings.
The Microbiology Society's Annual Conference 2026 will bring together researchers from around the world to discuss antimicrobial resistance and its impact on global health. The conference will explore ways to slow the spread of superbugs through scientific research, policy, and international collaboration.
Researchers discovered that mutations in a key protein make yeast found in dogs with common outer ear infections more resistant to topical antifungals. The team recommends using shorter-tailed azoles as initial therapy for dogs with yeast ear infections, reserving longer-tailed azoles for recurrent or non-responsive cases.
A Northwestern University study finds that disinfectants like chlorhexidine linger on surfaces for longer than previously known, allowing microbes to build tolerance. Chlorhexidine-tolerant bacteria were also detected spreading through touch and airborne dust across hospital rooms.
Researchers have identified phage W5 as a safe and effective natural virus capable of eliminating harmful Salmonella on various foods and packaging materials. The study establishes a solid foundation for developing novel phage-based disinfectants or preservatives to combat antibiotic resistance and enhance food safety.
Scientists have found evidence that glyphosate, a widely used weedkiller, can select for drug-resistant bacteria that can thrive in agricultural areas and then spread to hospitals. The study revealed that bacterial strains from hospital infections with extreme drug resistance showed high resistance to glyphosate and its byproducts.
The European Region is struggling to detect and treat tuberculosis, with 1 in 5 cases going undiagnosed or unreported. Drug-resistant strains are also a major concern, with the region accounting for a disproportionate share of global cases.
Using azithromycin within one day triggers antibiotic resistance in the respiratory tract, according to a study published in Nature Microbiology. The researchers followed hospitalized COVID-19 patients and found that azithromycin changed the mix of microbes in the upper airway, leading to persistent changes for more than a week.
Research shows that bacteria harbor resistance genes may respond differently to antibiotics under non-standard conditions. This affects treatment efficacy and contributes to understanding antimicrobial resistance development and spread. Understanding these variations is crucial to combat global public health threats.
A University of Sydney-led study found that honey made from mixed floral sources has superior performance against bacteria, with high levels of bioactive compounds. The findings could help develop new treatments for drug-resistant infections while supporting bushfire recovery and sustainable beekeeping practices.
Researchers design nanoagents to carry antibiotics deep into bacterial infections, releasing them upon gentle ultrasound activation. This approach reduces antibiotic resistance and improves treatment of biofilm-related infections.
A growing body of research suggests that microplastics in soils can alter microbial genes controlling essential ecosystem functions, potentially affecting food production, climate processes, and environmental health. Microplastics also enhance the spread of antibiotic resistance genes in soil ecosystems.
Researchers at Sultan Qaboos University have identified three novel antimicrobial peptides from dromedary camels that effectively target multidrug-resistant bacteria. The peptides, CdPG-3 and CdCATH, demonstrate strong antibacterial activity across Gram-positive and Gram-negative bacteria.
The study provides detailed information on NrdR, a master regulator of ribonucleotide reductases in bacteria. It reveals how NrdR senses nucleotide levels and controls RNR expression, providing a new strategic entry point for antimicrobial development.
A new joint report from EFSA and ECDC highlights the ongoing threat of antimicrobial resistance in common foodborne bacteria such as Salmonella and Campylobacter. Despite some encouraging signals, progress has been limited, and continued action is essential to slow the emergence and spread of antimicrobial-resistant bacteria.
Researchers discovered a 5,000-year-old bacterial strain in an underground ice cave that shows resistance to multiple modern antibiotics. The Psychrobacter SC65A.3 strain has over 100 resistance-related genes and can inhibit the growth of several major antibiotic-resistant superbugs.
A Dartmouth study found that plasmids can form tight clusters within bacterial communities, making them resistant to antibiotics and clinical treatments. This phenomenon introduces a new avenue for bacterial infections to become more difficult to treat.
A new study reveals cyanobacteria as major carriers of antibiotic resistance genes in estuarine ecosystems. The researchers found strong connections between microbial carbon and nitrogen cycling and the presence of resistance genes.
Researchers developed a novel CRISPR-based technology called pPro-MobV that can remove antibiotic-resistant elements from bacterial populations. The new tool uses gene-drive thinking and has the potential to combat antibiotic resistance in healthcare settings, environmental remediation, and microbiome engineering.
New research reveals microalgae play a hidden role in spreading antibiotic resistance genes in natural water environments. The study highlights how microalgae create microenvironments that foster the growth and transmission of these genes, often found in bacteria.
Researchers have designed antibodies that recognize a unique sugar found on bacterial cells, providing a potential new treatment for multidrug-resistant hospital-acquired infections. The target of the antibody is pseudaminic acid, a sugar molecule produced exclusively by bacteria and used to evade immune responses.
The lack of data on safety and dosage limits life-saving antibiotics from children in Australia, New Zealand, and the Pacific Islands. Only six out of 12 recommended antibiotics are licensed for children under 12, with standard doses often too low.
Biologists have discovered a new mode of communication inside cells that helps bacterial pathogens learn how to evade drugs. The findings, published in Nature Communications, describe how mobile genetic elements transfer DNA sequences, including antimicrobial resistance genes, in Listeria monocytogenes.
A comprehensive review highlights a critical obstacle in effective global surveillance: the lack of a unified standard for interpreting antibiotic resistance data. Researchers argue that differences in international testing standards can lead to conflicting conclusions about resistance trends.
Researchers are using advanced DNA sequencing technologies to monitor environmental reservoirs of antibiotic resistance genes and assess their impact on human health. The study highlights the importance of integrating gene detection, host identification, and quantitative analysis to evaluate environmental antibiotic resistance.
Computational analysis reveals two strategies: stealthy plasmids pick up new genes first, while manipulative plasmids help them spread rapidly. This 'stealth-first' process can aid in predicting future resistance threats and tracking their emergence.
Researchers have demonstrated that Janus nanoparticles can disrupt drug-resistant bacteria's defenses, restoring the effectiveness of conventional antibiotics. The approach uses nanoparticles to create pores in bacterial membranes, allowing antibiotics to flood in and execute their killing function.
Researchers at NUS Medicine discovered that genetic vectors can efficiently spread antibiotic resistance within the gut, enabling even highly virulent bacteria to acquire drug resistance. This finding sheds light on the emergence of 'superbugs' in healthcare settings.
The event highlighted urgent global risks and science-led solutions for antimicrobial resistance, trust in data, and AI-enabled sustainable cities. Experts emphasized the need for immediate actions against AMR, which could kill more people than cancer by 2050.
Antimicrobial resistance is expected to kill more people than cancer by 2050 due to increasing public mistrust and delayed policy-making. Experts urge immediate global action against AMR, emphasizing the need for trust in science, transparency, and openness to address this growing threat.
Researchers from New England Biolabs and Yale University have developed a first fully synthetic bacteriophage engineering system using the High-Complexity Golden Gate Assembly platform. This method simplifies strain engineering techniques, allowing for rapid creation of tailored therapeutic strains to overcome antibiotic resistance.
Salk Institute scientists found distinct disease courses and tolerance mechanisms in younger and older mice with sepsis, indicating a need for age-tailored therapies. The study suggests that future treatments may focus on controlling infection-generated damage rather than just targeting the pathogen.
A new diagnostic platform enables rapid and accurate detection of drug-resistant C. auris pathogens using CRISPR technology, allowing for more effective treatment and prevention of hospital outbreaks. The dSHERLOCK test can detect the presence of mutations causing antimicrobial resistance in just 40 minutes.
Researchers found that vermicomposting reduces antibiotic resistance genes by 70-95% and mobile genetic elements by up to 68%. The process uses earthworms to transform raw manure into a stable, high-value fertilizer.