Articles tagged with Antibiotic Resistance
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Researchers have discovered that combining antibiotics with an enzyme called endolysin can protect against infection by resistant bacteria in all bodily organs, including the brain. This breakthrough could lead to a new treatment for meningitis, a life-threatening disease caused by resistant bacteria.
Researchers at UiT The Arctic University of Norway discovered Staphylococcus borealis, a previously unknown bacterium resistant to several antibiotic classes. The study found that S. borealis can cause urinary tract infections and inflammation around implants in individuals with weakened immune systems.
Researchers at the University of Birmingham have identified a genetic code that enables the displacement of antibiotic resistance genes from bacteria. This discovery could lead to the development of new probiotics to combat antibiotic resistance in both animals and humans, making them reservoirs of this issue.
Scientists discovered that certain bacteria can trigger their own cell death as a defense mechanism against viruses, utilizing components of the bacterial immune system. This phenomenon could be exploited to develop novel antimicrobial treatments and fight drug-resistant infections.
A global study led by Stockholm Resilience Centre reveals that countries have the power to reduce antibiotic resistance through effective domestic interventions. The study found strong associations between country-level action and changes in antibiotic use and resistance, with a handful of countries leading the way.
A study of 73 countries found that national action plans have improved indicators of antibiotic resistance over time. Despite criticism, ambitious efforts by high and low-middle income countries are crucial to tackle antibiotic resistance.
A new study found that many home washing machines are insufficient for decontaminating healthcare worker uniforms, allowing antibiotic-resistant bacteria to survive. The researchers propose revising laundering guidelines or using on-site industrial machines to improve patient safety.
Mathematical modeling research from University of Utah Health suggests that treating moderate cases with antibiotics could limit the spread of cholera and reduce the likelihood of antibiotic resistance. In areas where cholera spreads slowly, aggressive antibiotic use may even stop outbreaks entirely.
Researchers have discovered a protein, Mfd, that promotes bacterial resistance and spontaneous mutations. A new compound, NM102, has been developed to block this protein, reducing the bacteria's ability to develop resistance and effectively combat antibiotic-resistant strains.
A new paint with a built-in bacteria-killing agent has been found to effectively kill MRSA, flu and COVID-19 on various surfaces. The paint, developed by scientists at the University of Nottingham, uses chlorhexidine to create an antimicrobial coating that can be applied to plastic and hard non-porous surfaces.
University of Oklahoma researchers create bioactive sugars to develop novel antibiotics against multi-drug-resistant infections in cancer patients. By using abundant, inexpensive, iron or metal-free, non-toxic blue light, the team can more easily and rapidly synthesize these important carbohydrates.
Researchers detected widespread contamination of retail chicken meat in Bangladesh with antibiotic-resistant E. albertii, a lesser-known but deadly pathogen. The study highlights the need for improved hygiene measures and stricter regulations to prevent foodborne infections.
A research team at HKU has developed a computational tool called Argo to track antibiotic resistance genes (ARGs) in environmental samples, providing insights into their transmission and associated risks. The tool uses long-read sequencing and can accurately identify and quantify ARGs, enhancing host identification accuracy.
The Microbiology Society has released new guides to communicating complex microbiology topics. The guides aim to support readers in writing about microbiology and promote safe communication of divisive topics.
A landmark study found that over 3 million children worldwide lost their lives in 2022 due to antimicrobial resistance (AMR)-related infections. The study data also revealed a sharp rise in the use of Watch and Reserve antibiotics, posing serious long-term risks.
A Chinese Academy of Sciences research team has identified the first mechanism of citrus resistance to citrus greening disease and developed an AI-assisted therapeutic approach. The discovery addresses the challenge of naturally occurring resistant genes in citrus, offering hope for global agricultural sustainability.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
A novel approach combines large language models and quantum computing to predict Salmonella antimicrobial resistance. The SARPLLM algorithm outperforms other models in prediction accuracy.
Recent cases of multi-drug resistant cholera in the UK and Germany are linked to exposure to contaminated holy water from Ethiopia. The study found a connection between pilgrims consuming or bathing in the holy well and the spread of the disease.
Researchers found that bacterial movement and flagellar rotation activate conjugation genes, enabling DNA transfer in liquid environments. This discovery provides insight into the spread of antibiotic resistance across species.
A new artificial intelligence-based method detects genetic markers of antibiotic resistance in bacteria, potentially leading to faster and more effective treatments. The method, called Group Association Model, uses machine learning to identify key mutations linked to drug resistance, reducing false positives and misdiagnoses.
A team of researchers found that a gene regulatory network in gut microbes plays an auxiliary role in bacterial fitness and adaptability. By maintaining basal levels of genetic activity, the network allows bacteria to adapt to their constantly changing environment.
A study by Umea University researchers identifies genes in Staphylococcus aureus that confer immunity against virus infection, a key mechanism to understand antibiotic resistance. Understanding this system could help develop new treatments for serious infections.
Researchers created a bacterial evolutionary map that tracks plasmid gene exchange and identifies barriers to treatment. The study reveals new insights into the co-evolution of plasmids and E. coli strains, paving the way for targeted therapies against antibiotic-resistant infections.
A study analyzing over 3 million bacterial samples found that antibiotic resistance initially rises but stabilizes over time, reaching an equilibrium in most species. The study suggests that continued increase in antibiotic resistance is not inevitable and provides new insights to monitor drug resistance.
Researchers have discovered a protective cloaking mechanism in jumbo phages that shield their genetic material from the host's immune system. This innovation could lead to new therapies for antibiotic-resistant infections.
A new study developed an AI model that can predict whether bacteria will become antibiotic-resistant by analyzing their genetic data. The model shows that antibiotic resistance is more easily transmitted between genetically similar bacteria and mainly occurs in wastewater treatment plants and inside the human body.
A study reveals that most Acinetobacter baumannii infections in a Malaysian hospital belonged to the Global Clone 2 lineage, which is also dominant worldwide. The majority of bacterial samples were resistant to multiple antibiotics, including carbapenems.
A team led by Gerry Wright has identified a strong candidate to challenge even some of the most drug-resistant bacteria: a new molecule called lariocidin. The molecule holds great promise as an early drug lead because it attacks bacteria in a way that's different from other antibiotics.
A multicenter study found targeted next-generation sequencing to significantly outperform traditional culture methods in detecting urinary tract infections, including polymicrobial cases. The method's detection time was notably shorter, with high concordance rates for both culture-positive and negative samples.
Researchers have made progress in understanding how Streptococcus pneumoniae constructs its capsule, a critical target for vaccine development. The study identified three categories of transporters that facilitate sugar building block transport, with relaxed specificity transporters posing potential risks to bacterial growth.
Antimicrobial Resistance (AMR) in wastewater poses a significant threat to human health due to the spread of drug-resistant pathogens. The Microbiology Society's new policy briefing outlines key interventions to tackle AMR in wastewater, including monitoring, stakeholder engagement, and treatment technologies.
A new study found regional and age-related trends in exposure to drug-resistant Campylobacter jejuni infections. Drug-resistant C. jejuni infections were highest among people aged 20-39, while certain states had significantly higher rates of resistance than others.
The Chinese Medical Association has released updated guidelines for pediatric mycoplasma pneumoniae infection, emphasizing a multi-faceted diagnostic approach and evidence-based treatment strategies. The guidelines highlight the importance of accurate diagnosis and responsible antibiotic use to combat rising resistance.
A new study using a microfluidic device found that certain infections may not be as resistant to antibiotics as previously thought. The researchers tested three different antibiotic agents against Pseudomonas aeruginosa and found a gradient of antibiotic activity dependent on the flow rate.
A new RNA barcoding method allows researchers to track gene transfer in bacterial communities without disrupting their natural environment. The technique has potential applications in predicting antibiotic resistance outbreaks, engineering microbiomes for pollution cleanup, and programming microbes for specific tasks like producing bio...
A new study suggests that sevelamer, a FDA-approved dialysis drug, can remove off-target antibiotics from the gut in mice. This could potentially prevent antibiotic resistance from emerging and protect current antibiotics from becoming ineffective.
Researchers found that curcumin enhances the effectiveness of bedaquiline in combating M. abscessus infections, with the combination showing synergistic enhancement of antibacterial activity. The study suggests potential new treatment pathways for resistant infections, particularly in immunocompromised populations.
Researchers found that lower doses (20mg) and higher doses (100mg) of doxycycline were equally effective in treating lymphocytic scarring alopecia, a rare skin condition causing permanent hair loss. The low-dose regimen resulted in fewer side effects and no compromise on efficacy or anti-inflammatory benefit.
A recent study has discovered that microplastics can facilitate the development of antimicrobial resistance in bacteria, even in the absence of antibiotics. The researchers used different types and sizes of plastic to expose E. coli bacteria to various antibiotics and found significant increases in multidrug resistance after exposure.
A new study from Weizmann Institute of Science reveals an immune mechanism involving proteasome products, which can kill bacteria and offer a promising treatment for infections. The researchers discovered that certain peptides produced by the proteasome have antibacterial properties and can be used to develop personalized treatments.
Professor Robert T. Schooley will present a talk at the 8th World Congress on Targeting Phage Therapy, exploring phage therapy advancements and necessary steps for widespread adoption. The congress will gather experts to discuss latest advances, challenges, and clinical applications of bacteriophage therapy.
A novel therapeutic strategy for superbug infections has been discovered using the siRNA-AGO2 complex. This complex inhibits bacterial gene translation by delivering AGO2-loaded siRNA into bacterial cytoplasm, downregulating resistance genes and converting multidrug-resistant bacteria into methicillin-sensitive ones.
A study found that soil bacterial communities show increased antimicrobial resistance due to the presence of a predatory bacterium, Myxococcus xanthus. The researchers suggest that exposure to growth-inhibitory molecules released by M. xanthus leads to the enrichment of resistant isolates.
A groundbreaking study has identified a dual-target approach that significantly prevents the development of resistance in bacteria. This approach combines membrane disruption with an additional critical cellular pathway, offering a potential solution to mitigate the escalating threat of antimicrobial resistance.
A new method for detecting antibiotic resistance genes (ARGs) in wastewater has been developed by researchers, which uses CRISPR-Cas9 technology to enrich ARG fragments and increase detection sensitivity. This enhanced method was found to detect 1189 more ARGs and 61 more ARG families compared to standard metagenomics methods.
Researchers from the University of Surrey found that a balance between reactive nitrogen species and reactive oxygen species affects drug-resistant bacteria. The study suggests treatments boosting reactive nitrogen species may be effective against antibiotic-resistant bacteria.
A new study published in the Journal of Antimicrobial Chemotherapy has found that lenacapavir is effective in controlling HIV in a population of patients in Uganda. The study sequenced the capsid proteins from 546 Ugandan patients and found little natural resistance to the drug.
A study found that even with impeccable cleaning, hospital sink drains can host bacterial populations that change over time. Dominant species include Stenotrophomonas and Pseudomonas aeruginosa, known to cause ventilator-associated pneumonia and sepsis.
A team of scientists has developed a cutting-edge technology to analyze bacterial sexually transmitted infections (STIs) using genome sequencing. The 'target enrichment' method enables high-resolution analysis of Chlamydia trachomatis and other pathogens, revealing new insights into their transmission and development pathways.
Researchers found that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, which can spread rapidly and evade treatment. Controlling blood sugar levels through insulin use may be key in preventing antibiotic resistance.
Researchers at San Francisco State University have developed a step-by-step machine learning tutorial to detect antibiotic resistance in patients. The team used a publicly available dataset to train four popular machine learning models, which can be easily accessed through Google Colab. The tutorial aims to make machine learning access...
Researchers at Texas A&M University have developed a low-cost technology using curcumin to curb bacterial resistance. The study shows that photodynamic inactivation can trigger deleterious reactions within bacteria, killing them and reducing the number of antibiotic-resistant strains.
Researchers at UCSF have discovered how a unique type of virus called a jumbo phage protects itself inside bacteria. The shield works via a set of secret handshakes that allow only useful proteins to pass through, giving the phage an advantage over regular phages when fighting infections.
Researchers from the University of Basel challenged the idea that persisters are responsible for antibiotic ineffectiveness. They found that nutrient starvation increases Salmonella resilience, making antibiotics less effective. This discovery could lead to more effective therapies against difficult-to-treat infections.
A new genomic toolkit called Sphae has been developed to quickly assess the suitability of phage therapy for treating antibiotic-resistant bacterial strains. The platform can analyze vast datasets in under 10 minutes, prioritizing safety and flagging genes associated with toxins or undesirable traits.
Carbapenem-resistant Enterobacterales, including K. pneumoniae and E. coli, pose a significant risk to EU/EEA patients and healthcare systems. The epidemiological situation has deteriorated since 2019, with high-risk lineages spreading in hospitals.
Recent studies have found that new antibiotics are prone to rapid development of resistance, even before they are widely used. This raises concerns about the effectiveness of these treatments in the long run. To address this issue, researchers call for a shift in antibiotic development prioritizing novel modes of action and responsible...
Researchers identified a unique genetic signature that can predict bacterial antibiotic resistance. The finding could help develop precision-based treatments and reduce overuse of antibiotics.
Researchers discovered a mechanism involving protein aggregation that allows bacteria to enter a dormant state, making them resistant to antibiotics. The study also found that protein aggregates can promote bacterial survival in stressful environments.