Research on how bacteria evade antibiotics. Covers adaptive metabolism, water-source resistance, drug-efflux pumps, and microplastic pollutant shuttles.
A new study reveals that bacteria can actively limit the spread of antibiotic resistance genes by deploying molecular gatekeepers called YokF. This mechanism blocks the transfer of beneficial genes, giving microbes a competitive advantage in dense microbial communities.
A recent study found that antibiotic-resistant bacteria are present in the gut microbiomes of American black bears in eastern North Carolina. The researchers also discovered that these pathogens can be dispersed through bear feces, making the bears a potential indicator species for environmental changes.
New findings render antibiotic-resistant bacteria vulnerable by disabling individual resistance and cross-protection. This approach offers new possibilities for treating resistant infections associated with cystic fibrosis and may inform the treatment of a broad range of antibiotic-resistant infections.
A major multi-country study found that WHO-recommended first-line antibiotics for neonatal sepsis are effective in only one quarter of infections in low- and middle-income countries. High levels of antimicrobial resistance were observed, making it challenging to identify consistently effective empirical antibiotic regimens.
A study analyzing meconium samples from newborns found high prevalence of antibiotic resistance genes, including those linked to carbapenem resistance. The findings suggest that maternal transmissions and early hospital exposure contribute to the establishment of these genes in the neonatal gut.
Researchers discovered highly antibiotic-resistant bacteria in wildlife samples, including foxes and birds, indicating potential early warning system for AMR spread. The study highlights the need for environmental interventions to prevent resistance from reaching clinical settings.
The Microbiology Society's Annual Conference 2026 will bring together researchers from around the world to discuss antimicrobial resistance and its impact on global health. The conference will explore ways to slow the spread of superbugs through scientific research, policy, and international collaboration.
Researchers discovered that mutations in a key protein make yeast found in dogs with common outer ear infections more resistant to topical antifungals. The team recommends using shorter-tailed azoles as initial therapy for dogs with yeast ear infections, reserving longer-tailed azoles for recurrent or non-responsive cases.
A Northwestern University study finds that disinfectants like chlorhexidine linger on surfaces for longer than previously known, allowing microbes to build tolerance. Chlorhexidine-tolerant bacteria were also detected spreading through touch and airborne dust across hospital rooms.
Researchers have identified phage W5 as a safe and effective natural virus capable of eliminating harmful Salmonella on various foods and packaging materials. The study establishes a solid foundation for developing novel phage-based disinfectants or preservatives to combat antibiotic resistance and enhance food safety.
Scientists have found evidence that glyphosate, a widely used weedkiller, can select for drug-resistant bacteria that can thrive in agricultural areas and then spread to hospitals. The study revealed that bacterial strains from hospital infections with extreme drug resistance showed high resistance to glyphosate and its byproducts.
The European Region is struggling to detect and treat tuberculosis, with 1 in 5 cases going undiagnosed or unreported. Drug-resistant strains are also a major concern, with the region accounting for a disproportionate share of global cases.
Using azithromycin within one day triggers antibiotic resistance in the respiratory tract, according to a study published in Nature Microbiology. The researchers followed hospitalized COVID-19 patients and found that azithromycin changed the mix of microbes in the upper airway, leading to persistent changes for more than a week.
Research shows that bacteria harbor resistance genes may respond differently to antibiotics under non-standard conditions. This affects treatment efficacy and contributes to understanding antimicrobial resistance development and spread. Understanding these variations is crucial to combat global public health threats.
A University of Sydney-led study found that honey made from mixed floral sources has superior performance against bacteria, with high levels of bioactive compounds. The findings could help develop new treatments for drug-resistant infections while supporting bushfire recovery and sustainable beekeeping practices.
Researchers design nanoagents to carry antibiotics deep into bacterial infections, releasing them upon gentle ultrasound activation. This approach reduces antibiotic resistance and improves treatment of biofilm-related infections.
A growing body of research suggests that microplastics in soils can alter microbial genes controlling essential ecosystem functions, potentially affecting food production, climate processes, and environmental health. Microplastics also enhance the spread of antibiotic resistance genes in soil ecosystems.
Researchers at Sultan Qaboos University have identified three novel antimicrobial peptides from dromedary camels that effectively target multidrug-resistant bacteria. The peptides, CdPG-3 and CdCATH, demonstrate strong antibacterial activity across Gram-positive and Gram-negative bacteria.
The study provides detailed information on NrdR, a master regulator of ribonucleotide reductases in bacteria. It reveals how NrdR senses nucleotide levels and controls RNR expression, providing a new strategic entry point for antimicrobial development.
A new joint report from EFSA and ECDC highlights the ongoing threat of antimicrobial resistance in common foodborne bacteria such as Salmonella and Campylobacter. Despite some encouraging signals, progress has been limited, and continued action is essential to slow the emergence and spread of antimicrobial-resistant bacteria.
Researchers discovered a 5,000-year-old bacterial strain in an underground ice cave that shows resistance to multiple modern antibiotics. The Psychrobacter SC65A.3 strain has over 100 resistance-related genes and can inhibit the growth of several major antibiotic-resistant superbugs.
A Dartmouth study found that plasmids can form tight clusters within bacterial communities, making them resistant to antibiotics and clinical treatments. This phenomenon introduces a new avenue for bacterial infections to become more difficult to treat.
A new study reveals cyanobacteria as major carriers of antibiotic resistance genes in estuarine ecosystems. The researchers found strong connections between microbial carbon and nitrogen cycling and the presence of resistance genes.
Researchers developed a novel CRISPR-based technology called pPro-MobV that can remove antibiotic-resistant elements from bacterial populations. The new tool uses gene-drive thinking and has the potential to combat antibiotic resistance in healthcare settings, environmental remediation, and microbiome engineering.
New research reveals microalgae play a hidden role in spreading antibiotic resistance genes in natural water environments. The study highlights how microalgae create microenvironments that foster the growth and transmission of these genes, often found in bacteria.
Researchers have designed antibodies that recognize a unique sugar found on bacterial cells, providing a potential new treatment for multidrug-resistant hospital-acquired infections. The target of the antibody is pseudaminic acid, a sugar molecule produced exclusively by bacteria and used to evade immune responses.
The lack of data on safety and dosage limits life-saving antibiotics from children in Australia, New Zealand, and the Pacific Islands. Only six out of 12 recommended antibiotics are licensed for children under 12, with standard doses often too low.
Biologists have discovered a new mode of communication inside cells that helps bacterial pathogens learn how to evade drugs. The findings, published in Nature Communications, describe how mobile genetic elements transfer DNA sequences, including antimicrobial resistance genes, in Listeria monocytogenes.
A comprehensive review highlights a critical obstacle in effective global surveillance: the lack of a unified standard for interpreting antibiotic resistance data. Researchers argue that differences in international testing standards can lead to conflicting conclusions about resistance trends.
Researchers are using advanced DNA sequencing technologies to monitor environmental reservoirs of antibiotic resistance genes and assess their impact on human health. The study highlights the importance of integrating gene detection, host identification, and quantitative analysis to evaluate environmental antibiotic resistance.
Researchers have demonstrated that Janus nanoparticles can disrupt drug-resistant bacteria's defenses, restoring the effectiveness of conventional antibiotics. The approach uses nanoparticles to create pores in bacterial membranes, allowing antibiotics to flood in and execute their killing function.
Researchers at NUS Medicine discovered that genetic vectors can efficiently spread antibiotic resistance within the gut, enabling even highly virulent bacteria to acquire drug resistance. This finding sheds light on the emergence of 'superbugs' in healthcare settings.
Computational analysis reveals two strategies: stealthy plasmids pick up new genes first, while manipulative plasmids help them spread rapidly. This 'stealth-first' process can aid in predicting future resistance threats and tracking their emergence.
The event highlighted urgent global risks and science-led solutions for antimicrobial resistance, trust in data, and AI-enabled sustainable cities. Experts emphasized the need for immediate actions against AMR, which could kill more people than cancer by 2050.
Antimicrobial resistance is expected to kill more people than cancer by 2050 due to increasing public mistrust and delayed policy-making. Experts urge immediate global action against AMR, emphasizing the need for trust in science, transparency, and openness to address this growing threat.
Researchers from New England Biolabs and Yale University have developed a first fully synthetic bacteriophage engineering system using the High-Complexity Golden Gate Assembly platform. This method simplifies strain engineering techniques, allowing for rapid creation of tailored therapeutic strains to overcome antibiotic resistance.
Salk Institute scientists found distinct disease courses and tolerance mechanisms in younger and older mice with sepsis, indicating a need for age-tailored therapies. The study suggests that future treatments may focus on controlling infection-generated damage rather than just targeting the pathogen.
A new diagnostic platform enables rapid and accurate detection of drug-resistant C. auris pathogens using CRISPR technology, allowing for more effective treatment and prevention of hospital outbreaks. The dSHERLOCK test can detect the presence of mutations causing antimicrobial resistance in just 40 minutes.
A new review highlights the growing threat of environmental antimicrobial resistance, which can spread through wastewater plants, farms, and oceans. The authors call for integrated surveillance to track resistance genes and prioritize traits that drive health risk, such as mobility, host pathogenicity, and multi-resistance.
A new study reveals that biodegradable plastics like PLA introduce a transient but intense risk window during breakdown, while conventional plastics like PVC pose a persistent threat as long-lived hubs for antibiotic resistance. The research highlights the need for considering the full life cycle of plastispheres in risk assessments.
Researchers found that vermicomposting reduces antibiotic resistance genes by 70-95% and mobile genetic elements by up to 68%. The process uses earthworms to transform raw manure into a stable, high-value fertilizer.
Climate change is releasing ancient antibiotic resistance genes from glaciers into rivers and lakes that supply drinking water, posing a significant risk to human health. The 'glacier continuum' concept highlights the need for monitoring programs and early-warning frameworks to track resistance gene spread.
The new clinical standards for antimicrobial stewardship in tuberculosis care aim to integrate TB into existing AMS frameworks, strengthening surveillance and resistance monitoring. The standards prioritize effectiveness, safety, and resistance prevention, promoting structured expert consultation services and targeted testing.
Researchers identify two archetypes of growth arrest that lead to persistence: regulated and disrupted states. The former provides protection from antibiotics, while the latter is marked by vulnerabilities, particularly impaired cell membrane stability. This distinction has significant implications for developing targeted therapies.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
A recent study found that tigecycline-resistant Klebsiella pneumoniae strains are predominantly identified in chicken feces in China, but have expanded to other ecological niches and countries. The researchers highlighted the importance of antimicrobial stewardship policies in controlling the spread of resistance genes.
New study reveals that viruses living on plastics can act as drivers of antibiotic resistance dissemination by transferring genetic material between bacteria. Environmental context is crucial in understanding the risks of plastic pollution on public health.
Researchers used robotics and 'click' chemistry to synthesize over 700 metal complexes in a week, identifying six potential new lead compounds. An iridium-based antibiotic candidate showed high effectiveness against bacteria while being non-toxic to human cells.
Researchers developed a tool to quickly identify resistant strains of S. aureus using genomic profiles and machine-learning models. The approach is based on gene-content information rather than highly detailed genomic profiles, making it more practical for real-life clinical contexts.
Researchers discovered a tiny RNA molecule called PreS that helps viruses copy their DNA more efficiently and boost replication in bacterial cells. This discovery provides important insights for designing smarter phage-based therapies against antibiotic-resistant infections.
A comprehensive review reveals that antibiotic resistance genes are ancient features of microbial life shaped by millions of years of evolution. Human activities such as agriculture, wastewater discharge, and global trade are accelerating the spread of these genes into disease-causing bacteria.
Researchers from HIRI analyzed over 24,000 bacterial genomes to demonstrate that common machine learning methods can lead to biased results. They found that conventional approaches may fail to capture true resistance signals and limit accuracy in new strains.
A recent study reveals that sampling biases in bacterial population structure can severely undermine the accuracy of AI models predicting antimicrobial resistance. The researchers recommend evaluating future methods to address this issue.
A new review highlights how complex microbial communities, including those in the human gut and environment, drive antimicrobial resistance evolution. The study identifies five pathways of horizontal gene transfer that enable bacteria to share resistance genes within communities.
The study evaluates the antimicrobial efficacy of Syzygium aromaticum (clove essential oil) and Salvadora persica (miswak) against key peri-implantitis pathogens. CEO and miswak exhibit promising activity, but a synergistic effect is not observed.
Pseudomonas aeruginosa uses the type VI secretion system (T6SS) to counterattack when attacked by other bacteria, but this defense mechanism also makes it more vulnerable to antibiotics.
Researchers found that natural humification processes in soil can influence microbial communities and ecological risks. Artificial humic substances added to paddy soil showed a strong enrichment of genes related to carbohydrate metabolism, suggesting microbes quickly mobilize additional carbon.
Researchers found that plant phenolic acids can dramatically boost the activity of existing antibiotics against multidrug resistant E. coli, reducing the chance of new resistance emerging. The compounds also make it easier for antibiotics to enter and stay inside bacterial cells.
A new perspective outlines an urgent scientific roadmap for understanding chemical-microbe interactions and their role in accelerating antimicrobial resistance. Emerging evidence highlights unexpected combined effects of pollutants at low levels, which can promote resistance even when each chemical is present alone.
A new study found that black carbon formed during wheat straw burning can significantly reduce the spread of antibiotic resistance genes in soil and soybean crops. Black carbon altered nutrient availability, modified the physical and chemical aging of mulch films, contributing to reduced gene transfer.