Inflammatory bowel disease (IBD), also known as "green cancer", is a chronic, non-specific disease of the intestine. IBD includes ulcerative colitis and Crohn's disease, both of which tend to be debilitating, lifelong conditions that can prove fatal in severe cases. Currently, there is no cure for IBD. The main clinical treatments are drugs such as aminosalicylic acid preparations and corticosteroids, but they are often accompanied by gastrointestinal problems, anaemia, and various intestinal complications. Finding alternative, more effective options is a priority for researchers.
In a study published in the KeAi journal Fundamental Research , researchers from China explored a treatment method using ultrasmall Au 25 – gold - nanoparticles. In previous studies, these nanoclusters have been found to effectively eliminate a variety of reactive oxygen species (ROS), a type of free radical molecule that can build up and damage DNA, RNA and proteins in a cell. Elevated levels of ROS are commonly found in the gastrointestinal tract of IBD patients.
The team found that administering Au 25 nanoclusters orally to mice suffering from colitis eliminated ROS, increased antioxidant enzymes, and inhibited pro-inflammatory cytokines, without any obvious side effects. According to one of the paper’s authors, Fei Wang of China’s The Seventh Affiliated Hospital of Sun Yat-Sen University, a reduction in the inflammation in the gastrointestinal tracts of the mice was observed within 24 hours. She adds: “And the fact that these nanoclusters can be administered orally, means there is no need for invasive procedures.”
In addition, the team found that the nanoclusters have a number of benefits when compared with natural enzymes used in traditional IBD treatments, including lower cost, better stability, mass synthesis and easier storage. Wang explains: “The storage of Au 25 nanoclusters was not affected by pH, temperature or solution medium, and their good physiological stability and acid resistance meant they were easily able to access the inflamed colon. They also have good biocompatibility and chemical stability and can remove a variety of ROS.”
Wang concludes: “Au 25 nanoclusters offer a promising strategy in the research field of nanomedicine therapy for IBD. We believe this study demonstrates their value as a scientific basis and experimental basis for the clinical treatment of IBD.”
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Contact the author: Fei Wang, fay_wong1116@hotmail.com ; Haisheng Qian, shqian@ahmu.edu.cn
The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 100 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).
Fundamental Research
Experimental study
Animals
An orally administered gold nanocluster with ROS scavenging for inflammatory bowel disease treatment
21-Jul-2022
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.