Researchers report that worms, fruit flies, and mice exposed to indole, a compound produced by gut bacteria, remained free of age-related infirmities over a greater fraction of their lifespan than animals that were not exposed to indole; the effect was not observed in animals lacking a functional aryl hydrocarbon receptor (AHR), and indole exposure reduced age-dependent changes in AHR-regulated gene expression.
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Article #17-06464: "Indoles from commensal bacteria extend healthspan," by Robert Sonowal et al.
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Proceedings of the National Academy of Sciences