Articles tagged with Life Span
Researchers reviewed grant data from 2015-2022, supporting investment in a strong evidence base for obesity and cancer research. Key areas of focus include obesity's impact on cancer treatment and survivorship, as well as disparities in cancer outcomes.
Researchers from Tohoku University and the University of Tokyo developed super exosomes that target senescent cells, improving frailty and physical performance in aged mice. The technology has potential applications in healthy aging, cognitive function, and reproductive medicine.
Misha Blagosklonny's work challenged traditional paradigms in aging biology, proposing that persistent growth-promoting signals drive age-related pathology. His hyperfunction theory integrates evolutionary concepts with molecular pathways, offering a comprehensive framework for understanding aging.
A new research perspective proposes that developmental and growth programs continue operating beyond their beneficial period, driving aging. Programmatic mechanisms of aging are supported by evidence from animal models and experimental observations.
A recent review suggests that consuming less protein could have greater health benefits and potentially extend lifespan. The review highlights the role of fibroblast growth factor 21 (FGF21) in slowing aging by improving metabolism, reducing cellular damage, and preserving healthy cell function.
Researchers found that lifelong PQQ and IPQ supplementation in senescence-accelerated mice reduced mortality risk during midlife and delayed aging progression. Middle-aged mouse supplementation also improved age-related muscular dysfunction. The study suggests a potential healthspan extension benefit of these compounds.
A global study led by NUS Medicine found that Singaporeans have the highest life expectancy and healthy life expectancy, but a growing number of years are spent in poor health. The morbidity gap has widened globally, with people spending more years lived with illness or disability.
Researchers found that preserving peroxisomes preserves mitochondrial health during aging by maintaining long, interconnected mitochondrial networks and reducing oxidative stress. The study identifies peroxisome homeostasis as a promising area for future aging research.
A new Global Burden of Disease study found that people are spending more years living with chronic disease and disability as global life expectancy increases. The analysis revealed that high-income countries face the widest morbidity gaps, while women consistently live longer but spend more years in poor health.
A comprehensive systematic review clarifies life expectancy across rare progeria disorders, revealing striking differences among subtypes. The analysis demonstrates that patients with Hutchinson-Gilford progeria syndrome have a median survival of 16 years, while those with mandibuloacral dysplasia type B have a median survival of 37 ye...
Researchers found that a 12-week lifestyle program combining exercise guidance, dietary counseling, and daily yogurt consumption significantly slowed DunedinPACE, an epigenetic measure of biological aging. The intervention resulted in a modest but statistically significant slowing of the pace of aging, corresponding to a 2.2% reduction.
A study of 585 older adults found that different patterns of depressive symptoms are associated with disability-free survival, differing between men and women. Stronger feelings of 'worthlessness' were a significant risk factor for men, while 'anxiety' was a bigger risk factor for women.
A US-based longitudinal study found that Black fathers have lower all-cause mortality rates by middle age compared to nonfathers. The association was not observed in White fathers, highlighting racial differences in health outcomes of fathers.
A new study found that DNA methylation aging biomarkers, such as GrimAge2 and DunedinPoAm, significantly mediate the relationship between social disadvantage and mortality risk. The findings suggest that epigenetic aging measures capture the cumulative effects of multiple social and environmental stressors.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
A Chinese endoscopy-screened cohort study found that genetic risk and lifestyle factors independently contribute to upper gastrointestinal cancer risk. Integrating genetic risk with lifestyle information may improve risk stratification and identify individuals most likely to benefit from screening and prevention.
Screening with a PSA blood test reduces prostate cancer deaths by approximately 2 for every 1,000 men screened. The review found that 500 men would need to be invited to screening to prevent one prostate cancer death.
The BHARAT study, led by the Indian Institute of Science, is a groundbreaking initiative that integrates clinical, molecular, lifestyle, and environmental data from diverse demographic groups in India. The study aims to develop population-specific biological aging signatures and predictive models tailored to Indian populations.
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
A multi-phase clinical study will examine dosing, safety and long-term effects of rapamycin in older adults to guide future research on extending health span. Researchers aim to establish evidence-based guidance for the drug's use and move beyond speculation.
A new metabolic theory proposes that a decline in glycolytic ATP production is the fundamental mechanism limiting lifespan. Species with an optimal rate of decline survived, suggesting that maintaining a stable glycolytic flux may support repair processes and tissue regeneration. The authors propose testing this hypothesis through expe...
The Barshop Institute will conduct the VITAL-H trial, evaluating the repurposing of FDA-approved medications to delay age-related health decline in generally healthy middle-aged adults. The trial aims to preserve everyday abilities during a critical window of midlife aging.
The 'SWISS100' study identified 37 proteins in centenarians' blood whose profile appears linked to slower ageing, with remarkably low oxidative stress markers. Centenarians also show profiles surprisingly close to those of younger individuals, particularly with youthful expression levels of regulatory proteins of the extracellular matrix.
Lifespan-extending treatments and dietary restriction have increased variance in age-at-death in vertebrates, failing to 'square the survival curve'. The findings highlight that current interventions do not equally benefit all individuals, leading to a biological lottery.
A cohort study of St. Louis adults found that heightened cumulative lifespan stress and elevated inflammation were associated with shorter survival among Black participants. The findings highlight the need for policies addressing structural racism and treatments reducing inflammation to reduce mortality disparities.
Research published in BMJ Medicine found that a mix of different types of physical activity may be best for prolonging the lifespan. Variety rather than total quantity alone is linked to a lower risk of death, with some activities associated with a 15% lower risk of death from all causes.
A new study shows that chronic low-dose pesticide exposure reduces the life span of wild lake fish in China by accelerating physiological aging. Fish from pesticide-impacted lakes exhibited shortened telomeres and truncated population structures, dominated by younger individuals.
Research led by University of Notre Dame biologist Jason Rohr found that chronic exposure to the insecticide chlorpyrifos causes fish to age faster at the cellular level, leading to accelerated aging and reduced lifespan. The study suggests that low-level exposures can silently accumulate damage over time.
The study found that women with two to three children tend to live the longest, while those with an above-average number of children have shorter lifespan. Pregnancies between ages 24 and 38 were also linked to more favorable aging patterns.
A comparative study of 117 mammal species found that reproductive suppression increases lifespan by an average of ten percent. The study suggests that blocking reproduction allows more energy to be directed towards longevity, with significant effects observed in various mammalian groups.
A new study published in Nature found that contraception and castration increase life expectancy in both males and females. In males, castration extends lifespan, while in females, various forms of sterilization are associated with increased life expectancy due to reduced energetic costs of pregnancy and lactation.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
Researchers argue that widely used proxies for aging may conflate genuine modifications with simpler effects on physiology. Targeting specific pathologies can extend lifespan without slowing aging process. Historically, increased human lifespan was primarily driven by reduced infectious disease mortality, not a fundamental slowing of a...
A European consortium developed a new decision-making framework to predict COPD exacerbation severity and prognostic risk, integrating three key factors: baseline health status, event intensity, and triggers. This framework, known as BAt model, aims to guide treatment strategies and improve consistency across clinical settings.
A study by University of California, Riverside scientists found that alternative RNA processing, or
Lung cancer screening has the potential to prevent 3 times more deaths and gain 3 times more life-years than current levels. Increasing awareness and accessibility of lung cancer screening could lead to wider adoption.
A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
Premature mortality among adults aged 18-64 increased by over 27% between 2012 and 2022, with racial disparities widening substantially. Despite contributing to Medicare, Black individuals are less likely to live long enough to reach the qualifying age for coverage, resulting in unrealized benefits.
Anthropologist Michael Gurven challenges youth-obsessed culture by exploring aging's physiological and societal aspects, asserting that evolution designed humans to live at least seven decades. Multigenerational cooperation played a key role in the evolution of a post-reproductive life stage.
A significant genetic correlation has been identified between childhood cognitive function and parental longevity, providing molecular evidence for the connection. The study found that shared genetic factors influence both early cognitive abilities and lifespan, with a genetic correlation of 0.35.
Stroke survivors' lived experiences reveal key factors that shape their physical and emotional wellbeing during recovery. The study highlights the importance of integrating lived experiences in stroke research to improve care models.
Researchers found that quitting smoking more than doubles survival time among patients with advanced cancers. The study shows the benefits of integrated smoking cessation interventions into cancer treatment plans.
A recent analysis found that former inmates report worse health than non-incarcerated peers, even years after release. The study, published in the Journal of the American Geriatrics Society, suggests that clinicians consider screening for incarceration history and connecting patients to supportive services.
A study by Max Planck Institute for Evolutionary Anthropology found that women generally outlive men, with females living 12% longer on average in most mammals. This gap is attributed to genetic differences, reproductive strategies, and parental investment, which provide a survival advantage to females.
Researchers found that a combination of oxytocin and an Alk5 inhibitor significantly extended the lifespan and healthspan of frail, elderly male mice, but not female mice. This dual-drug approach reduced chronic inflammation and tissue damage, leading to improved physical endurance and memory in males.
Rates of alcohol-induced deaths in the US nearly doubled between 1999 and 2024, reaching a record high in 2021. The largest increase was among females aged 25-34, with mortality rates rising by 255%.
A new perspective suggests that food-derived signals can modulate biological aging by influencing lifestyle choices such as diet, physical activity, and sleep. Targeted nutritional approaches have been shown to slow down aging and preserve cognitive function, highlighting the potential of precision nutrition interventions.
A new study by University of Wisconsin-Madison researchers found that life expectancy gains made in high-income countries have slowed significantly since the first half of the 20th century. As a result, none of the generations born after 1939 will reach 100 years of age on average.
Researchers based calculations on six different methods and found life expectancy for those born between 1939 and 2000 is rising more slowly. The rate of increase slowed by 37-52% depending on the method used, with forecasts indicating none of these cohorts will reach 100 years of life expectancy.
A new research paper found that epigenetic aging is linked to cognitive decline in midlife, with twins experiencing a larger drop in IQ scores if they had grown up in families with lower socioeconomic status. This study provides new evidence for the impact of childhood adversity on brain aging.
A comparative effectiveness study estimates that COVID-19 vaccinations averted 2.5 million deaths during 2020-2024, with the majority of benefits secured for older adults within this age group.
A new study finds that risk-reducing mastectomy is cost-effective for women aged 30-55 with a lifetime breast cancer risk of 35% or higher. The findings have significant clinical implications, suggesting that RRM could expand access to the procedure beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers.
A pooled data analysis of 85 studies found that consistently physically active adults had a 30–40% lower risk of death from any cause. Increasing physical activity levels also resulted in a 20–25% lower risk of death, with switching to an active lifestyle at any point extending lifespan.
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
Research from Mass General Brigham found that individuals with shorter telomeres and less optimal lifestyle choices are at greater risk for stroke, dementia, and late-life depression. However, those with healthier lifestyles showed no increased risk, suggesting a potential mitigation effect.
Researchers developed a blood-based proteomic score to predict healthy aging and age-related diseases. A lower score is associated with higher mortality and disease risk, offering a powerful tool for understanding biological aging.
A recent study by Iowa State University researchers found that fruit flies missing a crucial developmental hormone, PTTH, live up to 30% longer due to reduced inflammaging. The connection between developmental timing and lifespan in fruit flies could be a useful model for studying human longevity.
A study of 2,268 US individuals aged 60+ found strong association between social activities and low 4-year mortality risk. High social engagement, such as charity work and sports participation, was significantly linked to reduced risk of dying.
New research by the University of Bristol and Cats Protection reveals that road traffic accidents are the leading cause of death in UK pet cats under 8 years old. The study found that younger cats are at higher risk of death due to RTAs, while older cats are more likely to die from disease-related causes.