About The Study: In this cohort study of St. Louis adults, heightened cumulative lifespan stress and elevated inflammation were associated with shorter survival among Black participants, suggesting these pathways may represent plausible mechanisms mediating racial disparities in mortality among Black and white U.S. individuals. The findings underscore the need for policies that address structural racism, alongside treatments that reduce inflammation and limit stress exposure to reduce mortality disparities.
Corresponding Author: To contact the corresponding author, Ryan Bogdan, PhD, email rbogdan@wustl.edu .
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(doi:10.1001/jamanetworkopen.2025.54701)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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