Researchers report that exposure to the antimicrobial compound triclosan suppressed the high fat diet-induced expression of the metabolic regulator FGF21 and significantly altered expression of genes involved in amino acid and lipid metabolism in mice; in a mouse model of type I diabetes, triclosan accelerated development of nonalcoholic steatohepatitis (NASH) and liver fibrosis, and led to changes in the gut microbiota consistent with those observed in NASH patients.
Article #20-17129: "Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease," by Mei-Fei Yueh et al.
MEDIA CONTACT: Robert H. Tukey, University of California, San Diego, La Jolla, CA; e-mail: < rtukey@ucsd.edu >; Michael Karin, University of California, San Diego, La Jolla, CA; tel: 858-534-1361; e-mail: mkarin@ucsd.edu
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Proceedings of the National Academy of Sciences