There was a very strong inverse relationship between post-immune anti-P. gingivalis HSP immunoglobulin G levels and the amount of alveolar bone loss induced by either P. gingivalis or multiple bacterial infection (p = 0.007). Analysis of data from polymerase chain-reaction indicated that the vaccine successfully eradicated the multiple pathogenic species.
The researchers concluded that P. gingivalis HSP60 could potentially be developed as a vaccine to inhibit periodontal disease induced by multiple pathogenic bacteria.
This is a summary of abstract #2391, "Porphyromonas gingivalis HSP Vaccine Reduces Alveolar Bone Loss," by J.-I. Choi, J.-Y. Lee, S.-J. Kim, and N.N.-Yi, of Pusan National University, South Korea, to be presented at 3:30 p.m. on Friday, June 30, 2006, in Exhibit Hall 1 of the Brisbane Convention & Exhibition Centre, during the 84th General Session of the International Association for Dental Research.
Journal of Dental Research