Regulatory T cells (Tregs) function to suppress immune responses of other cells, and their dysfunction has been associated with development of immune disorders. Recent studies suggest that Tregs maintain plasticity even after differentiation, and can be influenced to change their regulatory profile. In this issue of the Journal of Clinical Investigation , Yun-Cai Liu and colleagues at the La Jolla Institute for Allergy and Immunology identified the E3 ubiquitin ligase Itch as a regulator of Tregs stability. The authors found that in the absence of Itch, Tregs took on a Th2 phenotype, which promoted the development of severe antigen-induced airway inflammation, skin lesion formation and other inflammatory characteristics in mice. In a companion commentary, WanJun Chen of the National Institutes of Health discusses the implications of this study on our understanding of allergy and asthma development.
TITLE:
Itch expression by Treg cells controls Th2 inflammatory responses
AUTHOR CONTACT:
Yun-Cai Liu
La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
Phone: 858-752-6810; Fax: 858-752-6985; E-mail: yuncail@liai.org
View this article at: http://www.jci.org/articles/view/69355?key=34db86acfb334e362aa5
ACCOMPANYING COMMENTARY
Regulatory T cells use "Itch" to control asthma
Wanjun Chen
Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA
Phone: 301-435-7168; Fax: 301-4021064; E-mail: wchen@dir.nidcr.nih.gov
View this article at: http://www.jci.org/articles/view/72477?key=1155af77c3a6e661aeb8
Journal of Clinical Investigation